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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RARA_HUMAN (P10276)

Summary

This is the summary of UniProt entry RARA_HUMAN (P10276).

Description: Retinoic acid receptor alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 462 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 7
disorder n/a 11 12
low_complexity n/a 19 30
disorder n/a 46 47
disorder n/a 52 76
low_complexity n/a 65 70
low_complexity n/a 65 80
Pfam zf-C4 86 155
disorder n/a 159 166
Pfam Hormone_recep 224 401
disorder n/a 346 349
disorder n/a 374 375
disorder n/a 407 462
low_complexity n/a 425 442
low_complexity n/a 439 462

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P10276. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTTLQHQLPV
50
51
SGYSTPSPAT IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY
100
101
GVSACEGCKG FFRRSIQKNM VYTCHRDKNC IINKVTRNRC QYCRLQKCFE
150
151
VGMSKESVRN DRNKKKKEVP KPECSESYTL TPEVGELIEK VRKAHQETFP
200
201
ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV EFAKQLPGFT
250
251
TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA
300
301
GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDRVDM
350
351
LQEPLLEALK VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM
400
401
EIPGSMPPLI QEMLENSEGL DTLSGQPGGG GRDGGGLAPP PGSCSPSLSP
450
451
SSNRSSPATH SP                                         
462
 

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Checksums:
CRC64:E8D1CF9A1E57CB99
MD5:edeb62b89ac7410dacc89087e128843d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Hormone_recep 224 - 401 1DKF B 224 - 401 Show 3D Structure View in InterPro
3A9E B 224 - 401 Show 3D Structure View in InterPro
3KMR A 224 - 401 Show 3D Structure View in InterPro
3KMZ A 224 - 401 Show 3D Structure View in InterPro
B 224 - 401 Show 3D Structure View in InterPro
4DQM A 224 - 401 Show 3D Structure View in InterPro
C 224 - 401 Show 3D Structure View in InterPro
5K13 A 224 - 401 Show 3D Structure View in InterPro
7AOS B 224 - 401 Show 3D Structure View in InterPro
7APO A 224 - 401 Show 3D Structure View in InterPro
B 224 - 401 Show 3D Structure View in InterPro
zf-C4 86 - 155 6XWG D 86 - 155 Show 3D Structure View in InterPro
87 - 155 1DSZ A 1134 - 1202 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;