Summary
This is the summary of UniProt entry 1C07_HUMAN (P10321).
| Description: | HLA class I histocompatibility antigen, Cw-7 alpha chain |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 366 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 24 |
| low_complexity | n/a | 7 | 18 |
| Pfam | MHC_I | 25 | 203 |
| disorder | n/a | 62 | 64 |
| disorder | n/a | 68 | 81 |
| disorder | n/a | 86 | 90 |
| disorder | n/a | 118 | 123 |
| disorder | n/a | 168 | 171 |
| low_complexity | n/a | 168 | 184 |
| disorder | n/a | 200 | 217 |
| Pfam | C1-set | 211 | 290 |
| disorder | n/a | 243 | 259 |
| disorder | n/a | 292 | 298 |
| transmembrane | n/a | 308 | 331 |
| low_complexity | n/a | 311 | 327 |
| low_complexity | n/a | 332 | 345 |
| Pfam | MHC_I_C | 338 | 365 |
| low_complexity | n/a | 341 | 356 |
| disorder | n/a | 348 | 349 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P10321. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG
50 51
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV
100 101
SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL
150 151
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK
200 201
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
250 251
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
300 301
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC
350 351
SNSAQGSDES LITCKA
366
Show the unformatted sequence. |
| Checksums: |
CRC64:59C23D95FD1D0BC8
MD5:59f04e9673074518e8bd30cfc9d88d00
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| C1-set | 211 - 290 | 5VGE | A | 187 - 266 | Jmol OpenAstexViewer |
| MHC_I | 26 - 203 | 5VGE | A | 2 - 179 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
