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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: 1C07_HUMAN (P10321)

Summary

This is the summary of UniProt entry 1C07_HUMAN (P10321).

Description: HLA class I histocompatibility antigen, Cw-7 alpha chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 366 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 24
low_complexity n/a 7 18
Pfam MHC_I 25 203
disorder n/a 62 64
disorder n/a 68 81
disorder n/a 86 90
disorder n/a 118 123
disorder n/a 168 171
low_complexity n/a 168 184
disorder n/a 200 217
Pfam C1-set 211 290
disorder n/a 243 259
disorder n/a 292 298
transmembrane n/a 308 331
low_complexity n/a 311 327
low_complexity n/a 332 345
Pfam MHC_I_C 338 365
low_complexity n/a 341 356
disorder n/a 348 349

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P10321. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG
50
51
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV
100
101
SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL
150
151
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK
200
201
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
250
251
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
300
301
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC
350
351
SNSAQGSDES LITCKA                                     
366
 

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Checksums:
CRC64:59C23D95FD1D0BC8
MD5:59f04e9673074518e8bd30cfc9d88d00

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1-set 211 - 290 5VGE A 187 - 266 Jmol OpenAstexViewer
MHC_I 26 - 203 5VGE A 2 - 179 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.