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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DPO3A_ECOLI (P10443)

Summary

This is the summary of UniProt entry DPO3A_ECOLI (P10443).

Description: DNA polymerase III subunit alpha
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 1160 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PHP 8 173
disorder n/a 230 238
Pfam DNA_pol3_alpha 290 558
disorder n/a 317 320
low_complexity n/a 378 392
Pfam DNA_pol3_finger 561 735
disorder n/a 713 714
disorder n/a 723 724
Pfam HHH_6 808 898
Pfam tRNA_anti-codon 994 1073

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P10443. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSEPRFVHLR VHSDYSMIDG LAKTAPLVKK AAALGMPALA ITDFTNLCGL
50
51
VKFYGAGHGA GIKPIVGADF NVQCDLLGDE LTHLTVLAAN NTGYQNLTLL
100
101
ISKAYQRGYG AAGPIIDRDW LIELNEGLIL LSGGRMGDVG RSLLRGNSAL
150
151
VDECVAFYEE HFPDRYFLEL IRTGRPDEES YLHAAVELAE ARGLPVVATN
200
201
DVRFIDSSDF DAHEIRVAIH DGFTLDDPKR PRNYSPQQYM RSEEEMCELF
250
251
ADIPEALANT VEIAKRCNVT VRLGEYFLPQ FPTGDMSTED YLVKRAKEGL
300
301
EERLAFLFPD EEERLKRRPE YDERLETELQ VINQMGFPGY FLIVMEFIQW
350
351
SKDNGVPVGP GRGSGAGSLV AYALKITDLD PLEFDLLFER FLNPERVSMP
400
401
DFDVDFCMEK RDQVIEHVAD MYGRDAVSQI ITFGTMAAKA VIRDVGRVLG
450
451
HPYGFVDRIS KLIPPDPGMT LAKAFEAEPQ LPEIYEADEE VKALIDMARK
500
501
LEGVTRNAGK HAGGVVIAPT KITDFAPLYC DEEGKHPVTQ FDKSDVEYAG
550
551
LVKFDFLGLR TLTIINWALE MINKRRAKNG EPPLDIAAIP LDDKKSFDML
600
601
QRSETTAVFQ LESRGMKDLI KRLQPDCFED MIALVALFRP GPLQSGMVDN
650
651
FIDRKHGREE ISYPDVQWQH ESLKPVLEPT YGIILYQEQV MQIAQVLSGY
700
701
TLGGADMLRR AMGKKKPEEM AKQRSVFAEG AEKNGINAEL AMKIFDLVEK
750
751
FAGYGFNKSH SAAYALVSYQ TLWLKAHYPA EFMAAVMTAD MDNTEKVVGL
800
801
VDECWRMGLK ILPPDINSGL YHFHVNDDGE IVYGIGAIKG VGEGPIEAII
850
851
EARNKGGYFR ELFDLCARTD TKKLNRRVLE KLIMSGAFDR LGPHRAALMN
900
901
SLGDALKAAD QHAKAEAIGQ ADMFGVLAEE PEQIEQSYAS CQPWPEQVVL
950
951
DGERETLGLY LTGHPINQYL KEIERYVGGV RLKDMHPTER GKVITAAGLV
1000
1001
VAARVMVTKR GNRIGICTLD DRSGRLEVML FTDALDKYQQ LLEKDRILIV
1050
1051
SGQVSFDDFS GGLKMTAREV MDIDEAREKY ARGLAISLTD RQIDDQLLNR
1100
1101
LRQSLEPHRS GTIPVHLYYQ RADARARLRF GATWRVSPSD RLLNDLRGLI
1150
1151
GSEQVELEFD                                            
1160
 

Show the unformatted sequence.

Checksums:
CRC64:1A4F75F373841716
MD5:f950e4fc98ec91abd0b4b3ead1e6026b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_pol3_alpha 290 - 558 2HNH A 290 - 558 Show 3D Structure View in InterPro
2HQA A 290 - 558 Show 3D Structure View in InterPro
4JOM A 290 - 558 Show 3D Structure View in InterPro
5FKU A 290 - 558 Show 3D Structure View in InterPro
5FKV A 290 - 558 Show 3D Structure View in InterPro
5FKW A 290 - 558 Show 3D Structure View in InterPro
5M1S A 290 - 558 Show 3D Structure View in InterPro
DNA_pol3_finger 561 - 735 2HNH A 561 - 735 Show 3D Structure View in InterPro
2HQA A 561 - 735 Show 3D Structure View in InterPro
4JOM A 561 - 735 Show 3D Structure View in InterPro
5FKU A 561 - 735 Show 3D Structure View in InterPro
5FKV A 561 - 735 Show 3D Structure View in InterPro
5FKW A 561 - 735 Show 3D Structure View in InterPro
5M1S A 561 - 735 Show 3D Structure View in InterPro
HHH_6 808 - 898 2HNH A 808 - 898 Show 3D Structure View in InterPro
2HQA A 808 - 898 Show 3D Structure View in InterPro
4JOM A 808 - 898 Show 3D Structure View in InterPro
5FKU A 808 - 898 Show 3D Structure View in InterPro
5FKV A 808 - 898 Show 3D Structure View in InterPro
5FKW A 808 - 898 Show 3D Structure View in InterPro
5M1S A 808 - 898 Show 3D Structure View in InterPro
PHP 8 - 173 2HNH A 8 - 173 Show 3D Structure View in InterPro
2HQA A 8 - 173 Show 3D Structure View in InterPro
4GX8 A 53 - 218 Show 3D Structure View in InterPro
B 53 - 218 Show 3D Structure View in InterPro
C 53 - 218 Show 3D Structure View in InterPro
D 53 - 218 Show 3D Structure View in InterPro
4GX9 A 53 - 218 Show 3D Structure View in InterPro
B 53 - 218 Show 3D Structure View in InterPro
C 53 - 218 Show 3D Structure View in InterPro
D 53 - 218 Show 3D Structure View in InterPro
4JOM A 8 - 173 Show 3D Structure View in InterPro
5FKU A 8 - 173 Show 3D Structure View in InterPro
5FKV A 8 - 173 Show 3D Structure View in InterPro
5FKW A 8 - 173 Show 3D Structure View in InterPro
5M1S A 8 - 173 Show 3D Structure View in InterPro
tRNA_anti-codon 994 - 1073 5FKU A 994 - 1073 Show 3D Structure View in InterPro
5FKV A 994 - 1073 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;