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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ODP2_HUMAN (P10515)

Summary

This is the summary of UniProt entry ODP2_HUMAN (P10515).

Description: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial EC=2.3.1.12
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 647 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 26 47
disorder n/a 72 73
disorder n/a 90 91
Pfam Biotin_lipoyl 92 165
disorder n/a 96 102
disorder n/a 104 114
disorder n/a 119 125
disorder n/a 130 131
disorder n/a 178 182
low_complexity n/a 182 210
disorder n/a 184 221
Pfam Biotin_lipoyl 219 293
disorder n/a 233 234
disorder n/a 236 241
disorder n/a 246 254
disorder n/a 257 259
disorder n/a 277 278
disorder n/a 305 351
low_complexity n/a 315 350
Pfam E3_binding 355 390
disorder n/a 371 372
disorder n/a 375 381
disorder n/a 383 390
low_complexity n/a 396 418
disorder n/a 403 409
Pfam 2-oxoacid_dh 417 647

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P10515. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWRVCARRAQ NVAPWAGLEA RWTALQEVPG TPRVTSRSGP APARRNSVTT
50
51
GYGGVRALCG WTPSSGATPR NRLLLQLLGS PGRRYYSLPP HQKVPLPSLS
100
101
PTMQAGTIAR WEKKEGDKIN EGDLIAEVET DKATVGFESL EECYMAKILV
150
151
AEGTRDVPIG AIICITVGKP EDIEAFKNYT LDSSAAPTPQ AAPAPTPAAT
200
201
ASPPTPSAQA PGSSYPPHMQ VLLPALSPTM TMGTVQRWEK KVGEKLSEGD
250
251
LLAEIETDKA TIGFEVQEEG YLAKILVPEG TRDVPLGTPL CIIVEKEADI
300
301
SAFADYRPTE VTDLKPQVPP PTPPPVAAVP PTPQPLAPTP SAPCPATPAG
350
351
PKGRVFVSPL AKKLAVEKGI DLTQVKGTGP DGRITKKDID SFVPSKVAPA
400
401
PAAVVPPTGP GMAPVPTGVF TDIPISNIRR VIAQRLMQSK QTIPHYYLSI
450
451
DVNMGEVLLV RKELNKILEG RSKISVNDFI IKASALACLK VPEANSSWMD
500
501
TVIRQNHVVD VSVAVSTPAG LITPIVFNAH IKGVETIAND VVSLATKARE
550
551
GKLQPHEFQG GTFTISNLGM FGIKNFSAII NPPQACILAI GASEDKLVPA
600
601
DNEKGFDVAS MMSVTLSCDH RVVDGAVGAQ WLAEFRKYLE KPITMLL   
647
 

Show the unformatted sequence.

Checksums:
CRC64:DD93A8E666E377C2
MD5:a6cdb8df0e43006ec96d68bc610cf4e9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
2-oxoacid_dh 417 - 647 3B8K A 331 - 561 Jmol OpenAstexViewer
6CT0 n/a 417 - 647 Jmol OpenAstexViewer
Biotin_lipoyl 219 - 293 1FYC A 10 - 84 Jmol OpenAstexViewer
1Y8N B 133 - 207 Jmol OpenAstexViewer
1Y8O B 133 - 207 Jmol OpenAstexViewer
1Y8P B 133 - 207 Jmol OpenAstexViewer
2Q8I B 133 - 207 Jmol OpenAstexViewer
3CRK C 133 - 207 Jmol OpenAstexViewer
D 133 - 207 Jmol OpenAstexViewer
3CRL C 133 - 207 Jmol OpenAstexViewer
D 133 - 207 Jmol OpenAstexViewer
221 - 293 2PNR C 135 - 207 Jmol OpenAstexViewer
G 135 - 207 Jmol OpenAstexViewer
92 - 165 2DNE A 8 - 81 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.