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37  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: THIO_HUMAN (P10599)

Summary

This is the summary of UniProt entry THIO_HUMAN (P10599).

Description: Thioredoxin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 105 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Thioredoxin 2 103

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P10599. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS
50
51
NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT
100
101
INELV                                                 
105
 

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Checksums:
CRC64:256F4E3C8A187693
MD5:d49ba1f4a8aed98459a97454e7816a64

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Thioredoxin 2 - 103 1AIU A 2 - 103 Show 3D Structure View in InterPro
1AUC A 2 - 103 Show 3D Structure View in InterPro
1CQG A 2 - 103 Show 3D Structure View in InterPro
1CQH A 2 - 103 Show 3D Structure View in InterPro
1ERT A 2 - 103 Show 3D Structure View in InterPro
1ERU A 2 - 103 Show 3D Structure View in InterPro
1ERV A 2 - 103 Show 3D Structure View in InterPro
1ERW A 2 - 103 Show 3D Structure View in InterPro
1MDI A 2 - 103 Show 3D Structure View in InterPro
1MDJ A 2 - 103 Show 3D Structure View in InterPro
1MDK A 2 - 103 Show 3D Structure View in InterPro
1TRS A 2 - 103 Show 3D Structure View in InterPro
1TRU A 2 - 103 Show 3D Structure View in InterPro
1TRV A 2 - 103 Show 3D Structure View in InterPro
1TRW A 2 - 103 Show 3D Structure View in InterPro
2HSH A 2 - 103 Show 3D Structure View in InterPro
2HXK A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
C 2 - 103 Show 3D Structure View in InterPro
2IFQ A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
C 2 - 103 Show 3D Structure View in InterPro
2IIY A 2 - 103 Show 3D Structure View in InterPro
3E3E A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
3KD0 A 2 - 103 Show 3D Structure View in InterPro
3M9J A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
3M9K A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
3QFA C 2 - 103 Show 3D Structure View in InterPro
D 2 - 103 Show 3D Structure View in InterPro
3QFB C 2 - 103 Show 3D Structure View in InterPro
D 2 - 103 Show 3D Structure View in InterPro
3TRX A 2 - 103 Show 3D Structure View in InterPro
4LL1 B 2 - 103 Show 3D Structure View in InterPro
D 2 - 103 Show 3D Structure View in InterPro
4LL4 B 2 - 103 Show 3D Structure View in InterPro
D 2 - 103 Show 3D Structure View in InterPro
4OO4 A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
4OO5 A 2 - 103 Show 3D Structure View in InterPro
4POK A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
C 2 - 103 Show 3D Structure View in InterPro
D 2 - 103 Show 3D Structure View in InterPro
4POL A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
C 2 - 103 Show 3D Structure View in InterPro
D 2 - 103 Show 3D Structure View in InterPro
4POM A 2 - 103 Show 3D Structure View in InterPro
B 2 - 103 Show 3D Structure View in InterPro
C 2 - 103 Show 3D Structure View in InterPro
D 2 - 103 Show 3D Structure View in InterPro
4PUF C 2 - 103 Show 3D Structure View in InterPro
D 2 - 103 Show 3D Structure View in InterPro
4TRX A 2 - 103 Show 3D Structure View in InterPro
5DQY A 2 - 103 Show 3D Structure View in InterPro
2 - 66 1M7T A 2 - 66 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;