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22  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KIT_HUMAN (P10721)

Summary

This is the summary of UniProt entry KIT_HUMAN (P10721).

Description: Mast/stem cell growth factor receptor Kit EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 976 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 25
low_complexity n/a 14 18
low_complexity n/a 24 38
disorder n/a 26 42
disorder n/a 79 85
low_complexity n/a 206 220
Pfam ig 216 305
transmembrane n/a 521 543
Pfam PK_Tyr_Ser-Thr 589 924
low_complexity n/a 758 770
disorder n/a 953 955
disorder n/a 957 958

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P10721. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PGEPSPPSIH PGKSDLIVRV
50
51
GDEIRLLCTD PGFVKWTFEI LDETNENKQN EWITEKAEAT NTGKYTCTNK
100
101
HGLSNSIYVF VRDPAKLFLV DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG
150
151
CQGKPLPKDL RFIPDPKAGI MIKSVKRAYH RLCLHCSVDQ EGKSVLSEKF
200
201
ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS SVYSTWKREN
250
251
SQTKLQEKYN SWHHGDFNYE RQATLTISSA RVNDSGVFMC YANNTFGSAN
300
301
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PKPEHQQWIY
350
351
MNRTFTDKWE DYPKSENESN IRYVSELHLT RLKGTEGGTY TFLVSNSDVN
400
401
AAIAFNVYVN TKPEILTYDR LVNGMLQCVA AGFPEPTIDW YFCPGTEQRC
450
451
SASVLPVDVQ TLNSSGPPFG KLVVQSSIDS SAFKHNGTVE CKAYNDVGKT
500
501
SAYFNFAFKG NNKEQIHPHT LFTPLLIGFV IVAGMMCIIV MILTYKYLQK
550
551
PMYEVQWKVV EEINGNNYVY IDPTQLPYDH KWEFPRNRLS FGKTLGAGAF
600
601
GKVVEATAYG LIKSDAAMTV AVKMLKPSAH LTEREALMSE LKVLSYLGNH
650
651
MNIVNLLGAC TIGGPTLVIT EYCCYGDLLN FLRRKRDSFI CSKQEDHAEA
700
701
ALYKNLLHSK ESSCSDSTNE YMDMKPGVSY VVPTKADKRR SVRIGSYIER
750
751
DVTPAIMEDD ELALDLEDLL SFSYQVAKGM AFLASKNCIH RDLAARNILL
800
801
THGRITKICD FGLARDIKND SNYVVKGNAR LPVKWMAPES IFNCVYTFES
850
851
DVWSYGIFLW ELFSLGSSPY PGMPVDSKFY KMIKEGFRML SPEHAPAEMY
900
901
DIMKTCWDAD PLKRPTFKQI VQLIEKQISE STNHIYSNLA NCSPNRQKPV
950
951
VDHSVRINSV GSTASSSQPL LVHDDV                          
976
 

Show the unformatted sequence.

Checksums:
CRC64:81B0CD76817F3454
MD5:f753f2b2d9752a30646c83e8630d1df8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ig 216 - 305 2E9W A 216 - 305 Show 3D Structure View in InterPro
B 216 - 305 Show 3D Structure View in InterPro
2EC8 A 216 - 305 Show 3D Structure View in InterPro
PK_Tyr_Ser-Thr 589 - 924 1PKG A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
1T45 A 589 - 924 Show 3D Structure View in InterPro
1T46 A 589 - 924 Show 3D Structure View in InterPro
3G0E A 589 - 924 Show 3D Structure View in InterPro
3G0F A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
4HVS A 589 - 924 Show 3D Structure View in InterPro
4U0I A 589 - 924 Show 3D Structure View in InterPro
6GQJ A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
6GQK A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
6GQL A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
6GQM A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
6HH1 A 589 - 924 Show 3D Structure View in InterPro
6ITT A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
6ITV A 589 - 924 Show 3D Structure View in InterPro
6KLA A 589 - 924 Show 3D Structure View in InterPro
6MOB A 589 - 924 Show 3D Structure View in InterPro
6XV9 A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
6XVA A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
6XVB A 589 - 924 Show 3D Structure View in InterPro
B 589 - 924 Show 3D Structure View in InterPro
718 - 725 2IUH B 201 - 208 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;