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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: 41_HUMAN (P11171)

Summary

This is the summary of UniProt entry 41_HUMAN (P11171).

Description: Protein 4.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 864 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 170
low_complexity n/a 73 88
low_complexity n/a 90 111
low_complexity n/a 105 114
disorder n/a 179 202
Pfam FERM_N 214 277
Pfam FERM_M 292 401
Pfam FERM_C 405 494
Pfam FA 499 542
disorder n/a 518 572
disorder n/a 574 667
low_complexity n/a 598 611
Pfam SAB 667 715
disorder n/a 670 746
coiled_coil n/a 671 691
disorder n/a 748 755
Pfam 4_1_CTD 753 860
disorder n/a 757 809
low_complexity n/a 787 805
disorder n/a 819 822
disorder n/a 832 842
disorder n/a 845 864

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P11171. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTTEKSLVTE AENSQHQQKE EGEEAINSGQ QEPQQEESCQ TAAEGDNWCE
50
51
QKLKASNGDT PTHEDLTKNK ERTSESRGLS RLFSSFLKRP KSQVSEEEGK
100
101
EVESDKEKGE GGQKEIEFGT SLDEEIILKA PIAAPEPELK TDPSLDLHSL
150
151
SSAETQPAQE ELREDPDFEI KEGEGLEECS KIEVKEESPQ SKAETELKAS
200
201
QKPIRKHRNM HCKVSLLDDT VYECVVEKHA KGQDLLKRVC EHLNLLEEDY
250
251
FGLAIWDNAT SKTWLDSAKE IKKQVRGVPW NFTFNVKFYP PDPAQLTEDI
300
301
TRYYLCLQLR QDIVAGRLPC SFATLALLGS YTIQSELGDY DPELHGVDYV
350
351
SDFKLAPNQT KELEEKVMEL HKSYRSMTPA QADLEFLENA KKLSMYGVDL
400
401
HKAKDLEGVD IILGVCSSGL LVYKDKLRIN RFPWPKVLKI SYKRSSFFIK
450
451
IRPGEQEQYE STIGFKLPSY RAAKKLWKVC VEHHTFFRLT STDTIPKSKF
500
501
LALGSKFRYS GRTQAQTRQA SALIDRPAPH FERTASKRAS RSLDGAAAVD
550
551
SADRSPRPTS APAITQGQVA EGGVLDASAK KTVVPKAQKE TVKAEVKKED
600
601
EPPEQAEPEP TEAWKVEKTH IEVTVPTSNG DQTQKLAEKT EDLIRMRKKK
650
651
RERLDGENIY IRHSNLMLED LDKSQEEIKK HHASISELKK NFMESVPEPR
700
701
PSEWDKRLST HSPFRTLNIN GQIPTGEGPP LVKTQTVTIS DNANAVKSEI
750
751
PTKDVPIVHT ETKTITYEAA QTDDNSGDLD PGVLLTAQTI TSETPSSTTT
800
801
TQITKTVKGG ISETRIEKRI VITGDADIDH DQVLVQAIKE AKEQHPDMSV
850
851
TKVVVHQETE IADE                                       
864
 

Show the unformatted sequence.

Checksums:
CRC64:B466E7A9D7FBF12B
MD5:700381d156881ba334e0ec3d009cd3a0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FERM_C 405 - 488 1GG3 A 196 - 279 Jmol OpenAstexViewer
B 196 - 279 Jmol OpenAstexViewer
C 196 - 279 Jmol OpenAstexViewer
3QIJ A 405 - 488 Jmol OpenAstexViewer
B 405 - 488 Jmol OpenAstexViewer
FERM_M 292 - 396 2RQ1 A 83 - 187 Jmol OpenAstexViewer
292 - 401 1GG3 A 83 - 192 Jmol OpenAstexViewer
B 83 - 192 Jmol OpenAstexViewer
C 83 - 192 Jmol OpenAstexViewer
3QIJ A 292 - 401 Jmol OpenAstexViewer
B 292 - 401 Jmol OpenAstexViewer
FERM_N 214 - 275 3QIJ A 214 - 275 Jmol OpenAstexViewer
214 - 277 1GG3 A 5 - 68 Jmol OpenAstexViewer
B 5 - 68 Jmol OpenAstexViewer
C 5 - 68 Jmol OpenAstexViewer
3QIJ B 214 - 277 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.