Summary
This is the summary of UniProt entry 41_HUMAN (P11171).
| Description: | Protein 4.1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 864 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 170 |
| low_complexity | n/a | 73 | 88 |
| low_complexity | n/a | 90 | 111 |
| low_complexity | n/a | 105 | 114 |
| disorder | n/a | 179 | 202 |
| Pfam | FERM_N | 214 | 277 |
| Pfam | FERM_M | 292 | 401 |
| Pfam | FERM_C | 405 | 494 |
| Pfam | FA | 499 | 542 |
| disorder | n/a | 518 | 572 |
| disorder | n/a | 574 | 667 |
| low_complexity | n/a | 598 | 611 |
| Pfam | SAB | 667 | 715 |
| disorder | n/a | 670 | 746 |
| coiled_coil | n/a | 671 | 691 |
| disorder | n/a | 748 | 755 |
| Pfam | 4_1_CTD | 753 | 860 |
| disorder | n/a | 757 | 809 |
| low_complexity | n/a | 787 | 805 |
| disorder | n/a | 819 | 822 |
| disorder | n/a | 832 | 842 |
| disorder | n/a | 845 | 864 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P11171. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MTTEKSLVTE AENSQHQQKE EGEEAINSGQ QEPQQEESCQ TAAEGDNWCE
50 51
QKLKASNGDT PTHEDLTKNK ERTSESRGLS RLFSSFLKRP KSQVSEEEGK
100 101
EVESDKEKGE GGQKEIEFGT SLDEEIILKA PIAAPEPELK TDPSLDLHSL
150 151
SSAETQPAQE ELREDPDFEI KEGEGLEECS KIEVKEESPQ SKAETELKAS
200 201
QKPIRKHRNM HCKVSLLDDT VYECVVEKHA KGQDLLKRVC EHLNLLEEDY
250 251
FGLAIWDNAT SKTWLDSAKE IKKQVRGVPW NFTFNVKFYP PDPAQLTEDI
300 301
TRYYLCLQLR QDIVAGRLPC SFATLALLGS YTIQSELGDY DPELHGVDYV
350 351
SDFKLAPNQT KELEEKVMEL HKSYRSMTPA QADLEFLENA KKLSMYGVDL
400 401
HKAKDLEGVD IILGVCSSGL LVYKDKLRIN RFPWPKVLKI SYKRSSFFIK
450 451
IRPGEQEQYE STIGFKLPSY RAAKKLWKVC VEHHTFFRLT STDTIPKSKF
500 501
LALGSKFRYS GRTQAQTRQA SALIDRPAPH FERTASKRAS RSLDGAAAVD
550 551
SADRSPRPTS APAITQGQVA EGGVLDASAK KTVVPKAQKE TVKAEVKKED
600 601
EPPEQAEPEP TEAWKVEKTH IEVTVPTSNG DQTQKLAEKT EDLIRMRKKK
650 651
RERLDGENIY IRHSNLMLED LDKSQEEIKK HHASISELKK NFMESVPEPR
700 701
PSEWDKRLST HSPFRTLNIN GQIPTGEGPP LVKTQTVTIS DNANAVKSEI
750 751
PTKDVPIVHT ETKTITYEAA QTDDNSGDLD PGVLLTAQTI TSETPSSTTT
800 801
TQITKTVKGG ISETRIEKRI VITGDADIDH DQVLVQAIKE AKEQHPDMSV
850 851
TKVVVHQETE IADE
864
Show the unformatted sequence. |
| Checksums: |
CRC64:B466E7A9D7FBF12B
MD5:700381d156881ba334e0ec3d009cd3a0
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| FERM_C | 405 - 488 | 1GG3 | A | 196 - 279 | Jmol OpenAstexViewer |
| B | 196 - 279 | Jmol OpenAstexViewer | |||
| C | 196 - 279 | Jmol OpenAstexViewer | |||
| 3QIJ | A | 405 - 488 | Jmol OpenAstexViewer | ||
| B | 405 - 488 | Jmol OpenAstexViewer | |||
| FERM_M | 292 - 396 | 2RQ1 | A | 83 - 187 | Jmol OpenAstexViewer |
| 292 - 401 | 1GG3 | A | 83 - 192 | Jmol OpenAstexViewer | |
| B | 83 - 192 | Jmol OpenAstexViewer | |||
| C | 83 - 192 | Jmol OpenAstexViewer | |||
| 3QIJ | A | 292 - 401 | Jmol OpenAstexViewer | ||
| B | 292 - 401 | Jmol OpenAstexViewer | |||
| FERM_N | 214 - 275 | 3QIJ | A | 214 - 275 | Jmol OpenAstexViewer |
| 214 - 277 | 1GG3 | A | 5 - 68 | Jmol OpenAstexViewer | |
| B | 5 - 68 | Jmol OpenAstexViewer | |||
| C | 5 - 68 | Jmol OpenAstexViewer | |||
| 3QIJ | B | 214 - 277 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
