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15  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ITAM_HUMAN (P11215)

Summary

This is the summary of UniProt entry ITAM_HUMAN (P11215).

Description: Integrin alpha-M
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1152 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 16
low_complexity n/a 1 12
disorder n/a 137 139
Pfam VWA 150 327
disorder n/a 216 219
disorder n/a 297 303
disorder n/a 343 347
Pfam FG-GAP 520 555
disorder n/a 538 541
disorder n/a 566 570
Pfam Integrin_alpha2 614 1005
disorder n/a 689 695
disorder n/a 902 903
disorder n/a 907 911
low_complexity n/a 1105 1126
transmembrane n/a 1106 1128
Pfam Integrin_alpha 1129 1143
disorder n/a 1143 1152

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P11215. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA
50
51
PQEIVAANQR GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP
100
101
QLLACGPTVH QTCSENTYVK GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD
150
151
IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL KKSKTLFSLM QYSEEFRIHF
200
201
TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN ITNGARKNAF
250
251
KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL
300
301
NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM
350
351
SQEGFSAAIT SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN
400
401
DAYLGYAAAI ILRNRVQSLV LGAPRYQHIG LVAMFRQNTG MWESNANVKG
450
451
TQIGAYFGAS LCSVDVDSNG STDLVLIGAP HYYEQTRGGQ VSVCPLPRGR
500
501
ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI GAPGEEDNRG
550
551
AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD
600
601
LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE
650
651
VRVCLHVQKS TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR
700
701
QTQVLGLTQT CETLKLQLPN CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP
750
751
VLAEDAQRLF TALFPFEKNC GNDNICQDDL SITFSFMSLD CLVVGGPREF
800
801
NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ RSWRLACESA
850
851
SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN
900
901
VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV
950
951
MQHQYQVSNL GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT
1000
1001
KERLPSHSDF LAELRKAPVV NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN
1050
1051
LSFDWYIKTS HNHLLIVSTA EILFNDSVFT LLPGQGAFVR SQTETKVEPF
1100
1101
EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM MSEGGPPGAE
1150
1151
PQ                                                    
1152
 

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Checksums:
CRC64:DF77408ED5EE25F9
MD5:9be54aa6a8fd72883628e39f744f64b4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Integrin_alpha 1129 - 1143 2LKE A 1 - 15 Jmol OpenAstexViewer
2LKJ A 1 - 15 Jmol OpenAstexViewer
VWA 150 - 326 4M76 B 134 - 310 Jmol OpenAstexViewer
150 - 327 1BHO 1 134 - 311 Jmol OpenAstexViewer
2 434 - 611 Jmol OpenAstexViewer
1BHQ 1 134 - 311 Jmol OpenAstexViewer
2 434 - 611 Jmol OpenAstexViewer
1IDN 1 134 - 311 Jmol OpenAstexViewer
2 434 - 611 Jmol OpenAstexViewer
1IDO A 134 - 311 Jmol OpenAstexViewer
1JLM A 134 - 311 Jmol OpenAstexViewer
1M1U A 134 - 311 Jmol OpenAstexViewer
1MF7 A 134 - 311 Jmol OpenAstexViewer
1N9Z A 134 - 311 Jmol OpenAstexViewer
1NA5 A 134 - 311 Jmol OpenAstexViewer
3Q3G E 134 - 311 Jmol OpenAstexViewer
G 134 - 311 Jmol OpenAstexViewer
I 134 - 311 Jmol OpenAstexViewer
L 134 - 311 Jmol OpenAstexViewer
3QA3 E 134 - 311 Jmol OpenAstexViewer
G 134 - 311 Jmol OpenAstexViewer
I 134 - 311 Jmol OpenAstexViewer
L 134 - 311 Jmol OpenAstexViewer
4XW2 A 134 - 311 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.