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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TOP2A_HUMAN (P11388)

Summary

This is the summary of UniProt entry TOP2A_HUMAN (P11388).

Description: DNA topoisomerase 2-alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1531 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 14 18
Pfam HATPase_c 76 225
disorder n/a 101 103
Pfam DNA_gyraseB 266 430
low_complexity n/a 333 351
disorder n/a 379 380
disorder n/a 441 443
Pfam Toprim 456 572
Pfam TOPRIM_C 573 711
low_complexity n/a 683 694
Pfam DNA_topoisoIV 713 1172
disorder n/a 716 718
disorder n/a 1089 1121
low_complexity n/a 1098 1116
coiled_coil n/a 1141 1161
disorder n/a 1146 1162
disorder n/a 1178 1524
low_complexity n/a 1191 1203
low_complexity n/a 1227 1242
low_complexity n/a 1294 1305
low_complexity n/a 1328 1347
low_complexity n/a 1405 1421
low_complexity n/a 1414 1433
Pfam DTHCT 1430 1522

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P11388. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEVSPLQPVN ENMQVNKIKK NEDAKKRLSV ERIYQKKTQL EHILLRPDTY
50
51
IGSVELVTQQ MWVYDEDVGI NYREVTFVPG LYKIFDEILV NAADNKQRDP
100
101
KMSCIRVTID PENNLISIWN NGKGIPVVEH KVEKMYVPAL IFGQLLTSSN
150
151
YDDDEKKVTG GRNGYGAKLC NIFSTKFTVE TASREYKKMF KQTWMDNMGR
200
201
AGEMELKPFN GEDYTCITFQ PDLSKFKMQS LDKDIVALMV RRAYDIAGST
250
251
KDVKVFLNGN KLPVKGFRSY VDMYLKDKLD ETGNSLKVIH EQVNHRWEVC
300
301
LTMSEKGFQQ ISFVNSIATS KGGRHVDYVA DQIVTKLVDV VKKKNKGGVA
350
351
VKAHQVKNHM WIFVNALIEN PTFDSQTKEN MTLQPKSFGS TCQLSEKFIK
400
401
AAIGCGIVES ILNWVKFKAQ VQLNKKCSAV KHNRIKGIPK LDDANDAGGR
450
451
NSTECTLILT EGDSAKTLAV SGLGVVGRDK YGVFPLRGKI LNVREASHKQ
500
501
IMENAEINNI IKIVGLQYKK NYEDEDSLKT LRYGKIMIMT DQDQDGSHIK
550
551
GLLINFIHHN WPSLLRHRFL EEFITPIVKV SKNKQEMAFY SLPEFEEWKS
600
601
STPNHKKWKV KYYKGLGTST SKEAKEYFAD MKRHRIQFKY SGPEDDAAIS
650
651
LAFSKKQIDD RKEWLTNFME DRRQRKLLGL PEDYLYGQTT TYLTYNDFIN
700
701
KELILFSNSD NERSIPSMVD GLKPGQRKVL FTCFKRNDKR EVKVAQLAGS
750
751
VAEMSSYHHG EMSLMMTIIN LAQNFVGSNN LNLLQPIGQF GTRLHGGKDS
800
801
ASPRYIFTML SSLARLLFPP KDDHTLKFLY DDNQRVEPEW YIPIIPMVLI
850
851
NGAEGIGTGW SCKIPNFDVR EIVNNIRRLM DGEEPLPMLP SYKNFKGTIE
900
901
ELAPNQYVIS GEVAILNSTT IEISELPVRT WTQTYKEQVL EPMLNGTEKT
950
951
PPLITDYREY HTDTTVKFVV KMTEEKLAEA ERVGLHKVFK LQTSLTCNSM
1000
1001
VLFDHVGCLK KYDTVLDILR DFFELRLKYY GLRKEWLLGM LGAESAKLNN
1050
1051
QARFILEKID GKIIIENKPK KELIKVLIQR GYDSDPVKAW KEAQQKVPDE
1100
1101
EENEESDNEK ETEKSDSVTD SGPTFNYLLD MPLWYLTKEK KDELCRLRNE
1150
1151
KEQELDTLKR KSPSDLWKED LATFIEELEA VEAKEKQDEQ VGLPGKGGKA
1200
1201
KGKKTQMAEV LPSPRGQRVI PRITIEMKAE AEKKNKKKIK NENTEGSPQE
1250
1251
DGVELEGLKQ RLEKKQKREP GTKTKKQTTL AFKPIKKGKK RNPWSDSESD
1300
1301
RSSDESNFDV PPRETEPRRA ATKTKFTMDL DSDEDFSDFD EKTDDEDFVP
1350
1351
SDASPPKTKT SPKLSNKELK PQKSVVSDLE ADDVKGSVPL SSSPPATHFP
1400
1401
DETEITNPVP KKNVTVKKTA AKSQSSTSTT GAKKRAAPKG TKRDPALNSG
1450
1451
VSQKPDPAKT KNRRKRKPST SDDSDSNFEK IVSKAVTSKK SKGESDDFHM
1500
1501
DFDSAVAPRA KSVRAKKPIK YLEESDEDDL F                    
1531
 

Show the unformatted sequence.

Checksums:
CRC64:3DF40BC9E84789DC
MD5:ae87b1102f96ae547f5c389e8403131a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_gyraseB 266 - 405 1ZXM A 266 - 405 Jmol OpenAstexViewer
266 - 411 1ZXM B 266 - 411 Jmol OpenAstexViewer
266 - 422 1ZXN A 266 - 422 Jmol OpenAstexViewer
4R1F A 266 - 422 Jmol OpenAstexViewer
266 - 424 1ZXN B 266 - 424 Jmol OpenAstexViewer
4R1F B 266 - 424 Jmol OpenAstexViewer
266 - 425 1ZXN D 266 - 425 Jmol OpenAstexViewer
4R1F D 266 - 425 Jmol OpenAstexViewer
266 - 426 1ZXN C 266 - 426 Jmol OpenAstexViewer
4R1F C 266 - 426 Jmol OpenAstexViewer
DNA_topoisoIV 713 - 1172 4FM9 A 713 - 1172 Jmol OpenAstexViewer
5GWK A 713 - 1172 Jmol OpenAstexViewer
B 713 - 1172 Jmol OpenAstexViewer
HATPase_c 76 - 225 1ZXM A 76 - 225 Jmol OpenAstexViewer
B 76 - 225 Jmol OpenAstexViewer
1ZXN A 76 - 225 Jmol OpenAstexViewer
B 76 - 225 Jmol OpenAstexViewer
C 76 - 225 Jmol OpenAstexViewer
D 76 - 225 Jmol OpenAstexViewer
4R1F A 76 - 225 Jmol OpenAstexViewer
B 76 - 225 Jmol OpenAstexViewer
C 76 - 225 Jmol OpenAstexViewer
D 76 - 225 Jmol OpenAstexViewer
Toprim 456 - 572 4FM9 A 456 - 572 Jmol OpenAstexViewer
5GWK A 456 - 572 Jmol OpenAstexViewer
B 456 - 572 Jmol OpenAstexViewer
TOPRIM_C 573 - 711 4FM9 A 573 - 711 Jmol OpenAstexViewer
5GWK A 573 - 711 Jmol OpenAstexViewer
B 573 - 711 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.