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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CP19A_HUMAN (P11511)

Summary

This is the summary of UniProt entry CP19A_HUMAN (P11511).

Description: Aromatase {ECO:0000303|PubMed:20385561}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 503 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
transmembrane n/a 20 39
low_complexity n/a 28 36
Pfam p450 46 488
coiled_coil n/a 241 261
transmembrane n/a 303 323

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P11511. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP
50
51
GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS
100
101
SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK
150
151
ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN
200
201
TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD
250
251
LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI
300
301
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI
350
351
QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
400
401
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI
450
451
LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC
500
501
LEH                                                   
503
 

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Checksums:
CRC64:9BD9B28651D9A69A
MD5:f3121c0f2c6fcd07561aed8758469019

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
p450 46 - 488 3EQM A 46 - 488 Jmol OpenAstexViewer
3S79 A 46 - 488 Jmol OpenAstexViewer
3S7S A 46 - 488 Jmol OpenAstexViewer
4GL5 A 46 - 488 Jmol OpenAstexViewer
4GL7 A 46 - 488 Jmol OpenAstexViewer
4KQ8 A 46 - 488 Jmol OpenAstexViewer
5JKV A 46 - 488 Jmol OpenAstexViewer
5JKW A 46 - 488 Jmol OpenAstexViewer
5JL6 A 46 - 488 Jmol OpenAstexViewer
5JL7 A 46 - 488 Jmol OpenAstexViewer
5JL9 A 46 - 488 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.