Summary
This is the summary of UniProt entry CP19A_HUMAN (P11511).
| Description: | Aromatase {ECO:0000303|PubMed:20385561} |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 503 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| transmembrane | n/a | 20 | 39 |
| low_complexity | n/a | 28 | 36 |
| Pfam | p450 | 46 | 488 |
| coiled_coil | n/a | 241 | 261 |
| transmembrane | n/a | 303 | 323 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P11511. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP
50 51
GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS
100 101
SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK
150 151
ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN
200 201
TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD
250 251
LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI
300 301
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI
350 351
QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
400 401
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI
450 451
LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC
500 501
LEH
503
Show the unformatted sequence. |
| Checksums: |
CRC64:9BD9B28651D9A69A
MD5:f3121c0f2c6fcd07561aed8758469019
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| p450 | 46 - 488 | 3EQM | A | 46 - 488 | Jmol OpenAstexViewer |
| 3S79 | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 3S7S | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 4GL5 | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 4GL7 | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 4KQ8 | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 5JKV | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 5JKW | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 5JL6 | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 5JL7 | A | 46 - 488 | Jmol OpenAstexViewer | ||
| 5JL9 | A | 46 - 488 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
