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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NFH_HUMAN (P12036)

Summary

This is the summary of UniProt entry NFH_HUMAN (P12036).

Description: Neurofilament heavy polypeptide
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1026 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 29 46
disorder n/a 37 46
low_complexity n/a 49 64
disorder n/a 51 53
disorder n/a 61 79
disorder n/a 82 84
disorder n/a 86 92
Pfam Filament 96 412
coiled_coil n/a 101 135
disorder n/a 123 134
disorder n/a 136 138
disorder n/a 141 145
low_complexity n/a 154 169
coiled_coil n/a 178 226
disorder n/a 180 183
low_complexity n/a 182 213
disorder n/a 185 193
disorder n/a 196 197
disorder n/a 241 259
low_complexity n/a 243 257
coiled_coil n/a 297 384
disorder n/a 308 309
disorder n/a 311 313
disorder n/a 317 320
disorder n/a 333 353
disorder n/a 416 420
disorder n/a 422 427
disorder n/a 429 434
low_complexity n/a 436 459
disorder n/a 442 444
disorder n/a 449 1026
low_complexity n/a 451 502
coiled_coil n/a 457 477
low_complexity n/a 498 519
low_complexity n/a 519 546
Pfam DUF1388 521 549
Pfam DUF1388 535 556
low_complexity n/a 544 580
Pfam DUF1388 569 590
low_complexity n/a 579 607
Pfam DUF1388 589 610
Pfam DUF1388 595 624
Pfam DUF1388 609 635
Pfam DUF1388 623 649
low_complexity n/a 643 675
Pfam DUF1388 663 692
Pfam DUF1388 677 706
low_complexity n/a 677 689
Pfam DUF1388 691 720
low_complexity n/a 691 703
low_complexity n/a 701 717
Pfam DUF1388 705 734
low_complexity n/a 715 731
low_complexity n/a 743 763
low_complexity n/a 810 863
low_complexity n/a 856 910
low_complexity n/a 912 927
low_complexity n/a 935 947
low_complexity n/a 939 987
low_complexity n/a 989 1005

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12036. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MMSFGGADAL LGAPFAPLHG GGSLHYALAR KGGAGGTRSA AGSSSGFHSW
50
51
TRTSVSSVSA SPSRFRGAGA ASSTDSLDTL SNGPEGCMVA VATSRSEKEQ
100
101
LQALNDRFAG YIDKVRQLEA HNRSLEGEAA ALRQQQAGRS AMGELYEREV
150
151
REMRGAVLRL GAARGQLRLE QEHLLEDIAH VRQRLDDEAR QREEAEAAAR
200
201
ALARFAQEAE AARVDLQKKA QALQEECGYL RRHHQEEVGE LLGQIQGSGA
250
251
AQAQMQAETR DALKCDVTSA LREIRAQLEG HAVQSTLQSE EWFRVRLDRL
300
301
SEAAKVNTDA MRSAQEEITE YRRQLQARTT ELEALKSTKD SLERQRSELE
350
351
DRHQADIASY QEAIQQLDAE LRNTKWEMAA QLREYQDLLN VKMALDIEIA
400
401
AYRKLLEGEE CRIGFGPIPF SLPEGLPKIP SVSTHIKVKS EEKIKVVEKS
450
451
EKETVIVEEQ TEETQVTEEV TEEEEKEAKE EEGKEEEGGE EEEAEGGEEE
500
501
TKSPPAEEAA SPEKEAKSPV KEEAKSPAEA KSPEKEEAKS PAEVKSPEKA
550
551
KSPAKEEAKS PPEAKSPEKE EAKSPAEVKS PEKAKSPAKE EAKSPAEAKS
600
601
PEKAKSPVKE EAKSPAEAKS PVKEEAKSPA EVKSPEKAKS PTKEEAKSPE
650
651
KAKSPEKAKS PEKEEAKSPE KAKSPVKAEA KSPEKAKSPV KAEAKSPEKA
700
701
KSPVKEEAKS PEKAKSPVKE EAKSPEKAKS PVKEEAKTPE KAKSPVKEEA
750
751
KSPEKAKSPE KAKTLDVKSP EAKTPAKEEA RSPADKFPEK AKSPVKEEVK
800
801
SPEKAKSPLK EDAKAPEKEI PKKEEVKSPV KEEEKPQEVK VKEPPKKAEE
850
851
EKAPATPKTE EKKDSKKEEA PKKEAPKPKV EEKKEPAVEK PKESKVEAKK
900
901
EEAEDKKKVP TPEKEAPAKV EVKEDAKPKE KTEVAKKEPD DAKAKEPSKP
950
951
AEKKEAAPEK KDTKEEKAKK PEEKPKTEAK AKEDDKTLSK EPSKPKAEKA
1000
1001
EKSSSTDQKD SKPPEKATED KAAKGK                          
1026
 

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Checksums:
CRC64:0879B6A08D208C17
MD5:800ba46f2e9947d104a9767c0bc74bd2

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.