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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GRAA_HUMAN (P12544)

Summary

This is the summary of UniProt entry GRAA_HUMAN (P12544).

Description: Granzyme A EC=3.4.21.78
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 262 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 9 19
Pfam Trypsin 29 254

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12544. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRNSYRFLAS SLSVVVSLLL IPEDVCEKII GGNEVTPHSR PYMVLLSLDR
50
51
KTICAGALIA KDWVLTAAHC NLNKRSQVIL GAHSITREEP TKQIMLVKKE
100
101
FPYPCYDPAT REGDLKLLQL MEKAKINKYV TILHLPKKGD DVKPGTMCQV
150
151
AGWGRTHNSA SWSDTLREVN ITIIDRKVCN DRNHYNFNPV IGMNMVCAGS
200
201
LRGGRDSCNG DSGSPLLCEG VFRGVTSFGL ENKCGDPRGP GVYILLSKKH
250
251
LNWIIMTIKG AV                                         
262
 

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Checksums:
CRC64:FD773628BA6F301B
MD5:94b91d86ed9203330132b40a21a5de40

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Trypsin 29 - 254 1OP8 A 16 - 238 Jmol OpenAstexViewer
B 16 - 238 Jmol OpenAstexViewer
C 16 - 238 Jmol OpenAstexViewer
D 16 - 238 Jmol OpenAstexViewer
E 16 - 238 Jmol OpenAstexViewer
F 16 - 238 Jmol OpenAstexViewer
1ORF A 16 - 238 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.