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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CADH1_HUMAN (P12830)

Summary

This is the summary of UniProt entry CADH1_HUMAN (P12830).

Description: Cadherin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 882 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 19
low_complexity n/a 4 20
Pfam Cadherin_pro 27 116
disorder n/a 116 130
disorder n/a 132 136
disorder n/a 156 157
Pfam Cadherin 159 253
disorder n/a 161 163
disorder n/a 169 170
disorder n/a 172 177
disorder n/a 189 192
disorder n/a 246 255
disorder n/a 261 264
disorder n/a 266 267
Pfam Cadherin 267 366
disorder n/a 279 288
low_complexity n/a 283 298
low_complexity n/a 356 370
disorder n/a 359 363
disorder n/a 366 368
disorder n/a 372 381
Pfam Cadherin 380 478
disorder n/a 395 397
disorder n/a 409 410
low_complexity n/a 463 479
Pfam Cadherin 491 585
disorder n/a 543 549
disorder n/a 596 600
Pfam Cadherin 598 686
disorder n/a 613 614
low_complexity n/a 702 730
transmembrane n/a 709 731
Pfam Cadherin_C 733 879
disorder n/a 741 742
disorder n/a 747 758
low_complexity n/a 752 765
disorder n/a 764 773
disorder n/a 778 780
disorder n/a 784 785
disorder n/a 793 795
disorder n/a 809 819
disorder n/a 821 823
disorder n/a 826 833
low_complexity n/a 836 852
disorder n/a 841 860
disorder n/a 876 877
disorder n/a 880 882

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12830. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR
50
51
VLGRVNFEDC TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV
100
101
YAWDSTYRKF STKVTLNTVG HHHRPPPHQA SVSGIQAELL TFPNSSPGLR
150
151
RQKRDWVIPP ISCPENEKGP FPKNLVQIKS NKDKEGKVFY SITGQGADTP
200
201
PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN AVEDPMEILI
250
251
TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI
300
301
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL
350
351
QGEGLSTTAT AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD
400
401
ADAPNTPAWE AVYTILNDDG GQFVVTTNPV NNDGILKTAK GLDFEAKQQY
450
451
ILHVAVTNVV PFEVSLTTST ATVTVDVLDV NEAPIFVPPE KRVEVSEDFG
500
501
VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG AISTRAELDR
550
551
EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI
600
601
FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI
650
651
ILKPKMALEV GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP
700
701
VEAGLQIPAI LGILGGILAL LILILLLLLF LRRRAVVKEP LLPPEDDTRD
750
751
NVYYYDEEGG GEEDQDFDLS QLHRGLDARP EVTRNDVAPT LMSVPRYLPR
800
801
PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS EAASLSSLNS
850
851
SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD                   
882
 

Show the unformatted sequence.

Checksums:
CRC64:E427118043A13C67
MD5:b61d2a33e504f9bc8257662a18aff76e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cadherin 159 - 253 1O6S B 5 - 99 Jmol OpenAstexViewer
2O72 A 5 - 99 Jmol OpenAstexViewer
2OMT B 5 - 99 Jmol OpenAstexViewer
2OMU B 5 - 99 Jmol OpenAstexViewer
2OMV B 5 - 99 Jmol OpenAstexViewer
2OMX B 5 - 99 Jmol OpenAstexViewer
2OMY B 5 - 99 Jmol OpenAstexViewer
2OMZ B 5 - 99 Jmol OpenAstexViewer
3FF7 A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
3FF8 A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
4ZT1 A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
4ZTE A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
267 - 366 2O72 A 113 - 212 Jmol OpenAstexViewer
4ZT1 A 113 - 212 Jmol OpenAstexViewer
B 113 - 212 Jmol OpenAstexViewer
4ZTE A 113 - 212 Jmol OpenAstexViewer
B 113 - 212 Jmol OpenAstexViewer
Cadherin_C 756 - 773 3L6X B 758 - 775 Jmol OpenAstexViewer
3L6Y B 758 - 775 Jmol OpenAstexViewer
D 758 - 775 Jmol OpenAstexViewer
F 758 - 775 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.