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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MYH7_HUMAN (P12883)

Summary

This is the summary of UniProt entry MYH7_HUMAN (P12883).

Description: Myosin-7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1935 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Myosin_N 34 73
disorder n/a 63 64
disorder n/a 70 72
Pfam Myosin_head 87 766
disorder n/a 208 209
disorder n/a 211 215
disorder n/a 368 381
disorder n/a 564 565
low_complexity n/a 632 640
disorder n/a 642 643
coiled_coil n/a 842 1156
Pfam Myosin_tail_1 843 1924
disorder n/a 892 893
disorder n/a 920 942
low_complexity n/a 920 935
disorder n/a 961 963
disorder n/a 965 966
disorder n/a 968 979
disorder n/a 1000 1014
disorder n/a 1018 1019
disorder n/a 1021 1022
disorder n/a 1031 1032
disorder n/a 1038 1040
disorder n/a 1042 1043
disorder n/a 1045 1047
disorder n/a 1061 1064
disorder n/a 1066 1068
disorder n/a 1070 1073
disorder n/a 1077 1078
low_complexity n/a 1109 1129
disorder n/a 1119 1120
disorder n/a 1126 1127
disorder n/a 1129 1131
low_complexity n/a 1132 1151
disorder n/a 1133 1134
disorder n/a 1146 1149
disorder n/a 1151 1198
coiled_coil n/a 1164 1184
coiled_coil n/a 1193 1374
disorder n/a 1200 1201
disorder n/a 1203 1205
disorder n/a 1211 1212
low_complexity n/a 1215 1227
disorder n/a 1224 1226
disorder n/a 1249 1289
disorder n/a 1291 1294
disorder n/a 1319 1321
disorder n/a 1326 1328
disorder n/a 1340 1348
low_complexity n/a 1344 1355
disorder n/a 1354 1359
disorder n/a 1373 1374
coiled_coil n/a 1376 1438
low_complexity n/a 1383 1393
disorder n/a 1391 1394
low_complexity n/a 1398 1408
disorder n/a 1408 1409
disorder n/a 1425 1429
disorder n/a 1436 1437
coiled_coil n/a 1453 1515
low_complexity n/a 1456 1472
disorder n/a 1463 1472
disorder n/a 1495 1497
disorder n/a 1499 1500
disorder n/a 1503 1504
disorder n/a 1506 1514
disorder n/a 1516 1517
disorder n/a 1520 1521
disorder n/a 1523 1531
coiled_coil n/a 1523 1589
disorder n/a 1534 1535
disorder n/a 1537 1549
low_complexity n/a 1538 1554
disorder n/a 1555 1556
disorder n/a 1574 1600
disorder n/a 1604 1617
coiled_coil n/a 1608 1712
disorder n/a 1622 1634
disorder n/a 1636 1638
disorder n/a 1640 1643
disorder n/a 1692 1694
disorder n/a 1699 1704
disorder n/a 1710 1712
disorder n/a 1717 1722
coiled_coil n/a 1720 1803
disorder n/a 1724 1805
low_complexity n/a 1804 1814
coiled_coil n/a 1805 1839
disorder n/a 1816 1852
coiled_coil n/a 1861 1923
disorder n/a 1879 1901
low_complexity n/a 1880 1888
disorder n/a 1904 1905
disorder n/a 1907 1935

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12883. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGDSEMAVFG AAAPYLRKSE KERLEAQTRP FDLKKDVFVP DDKQEFVKAK
50
51
IVSREGGKVT AETEYGKTVT VKEDQVMQQN PPKFDKIEDM AMLTFLHEPA
100
101
VLYNLKDRYG SWMIYTYSGL FCVTVNPYKW LPVYTPEVVA AYRGKKRSEA
150
151
PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFAVIAA
200
201
IGDRSKKDQS PGKGTLEDQI IQANPALEAF GNAKTVRNDN SSRFGKFIRI
250
251
HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM
300
301
LLITNNPYDY AFISQGETTV ASIDDAEELM ATDNAFDVLG FTSEEKNSMY
350
351
KLTGAIMHFG NMKFKLKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC
400
401
HPRVKVGNEY VTKGQNVQQV IYATGALAKA VYERMFNWMV TRINATLETK
450
451
QPRQYFIGVL DIAGFEIFDF NSFEQLCINF TNEKLQQFFN HHMFVLEQEE
500
501
YKKEGIEWTF IDFGMDLQAC IDLIEKPMGI MSILEEECMF PKATDMTFKA
550
551
KLFDNHLGKS ANFQKPRNIK GKPEAHFSLI HYAGIVDYNI IGWLQKNKDP
600
601
LNETVVGLYQ KSSLKLLSTL FANYAGADAP IEKGKGKAKK GSSFQTVSAL
650
651
HRENLNKLMT NLRSTHPHFV RCIIPNETKS PGVMDNPLVM HQLRCNGVLE
700
701
GIRICRKGFP NRILYGDFRQ RYRILNPAAI PEGQFIDSRK GAEKLLSSLD
750
751
IDHNQYKFGH TKVFFKAGLL GLLEEMRDER LSRIITRIQA QSRGVLARME
800
801
YKKLLERRDS LLVIQWNIRA FMGVKNWPWM KLYFKIKPLL KSAEREKEMA
850
851
SMKEEFTRLK EALEKSEARR KELEEKMVSL LQEKNDLQLQ VQAEQDNLAD
900
901
AEERCDQLIK NKIQLEAKVK EMNERLEDEE EMNAELTAKK RKLEDECSEL
950
951
KRDIDDLELT LAKVEKEKHA TENKVKNLTE EMAGLDEIIA KLTKEKKALQ
1000
1001
EAHQQALDDL QAEEDKVNTL TKAKVKLEQQ VDDLEGSLEQ EKKVRMDLER
1050
1051
AKRKLEGDLK LTQESIMDLE NDKQQLDERL KKKDFELNAL NARIEDEQAL
1100
1101
GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS RELEEISERL
1150
1151
EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV
1200
1201
AELGEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR
1250
1251
TLEDQMNEHR SKAEETQRSV NDLTSQRAKL QTENGELSRQ LDEKEALISQ
1300
1301
LTRGKLTYTQ QLEDLKRQLE EEVKAKNALA HALQSARHDC DLLREQYEEE
1350
1351
TEAKAELQRV LSKANSEVAQ WRTKYETDAI QRTEELEEAK KKLAQRLQEA
1400
1401
EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA ALDKKQRNFD
1450
1451
KILAEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR
1500
1501
ENKNLQEEIS DLTEQLGSSG KTIHELEKVR KQLEAEKMEL QSALEEAEAS
1550
1551
LEHEEGKILR AQLEFNQIKA EIERKLAEKD EEMEQAKRNH LRVVDSLQTS
1600
1601
LDAETRSRNE ALRVKKKMEG DLNEMEIQLS HANRMAAEAQ KQVKSLQSLL
1650
1651
KDTQIQLDDA VRANDDLKEN IAIVERRNNL LQAELEELRA VVEQTERSRK
1700
1701
LAEQELIETS ERVQLLHSQN TSLINQKKKM DADLSQLQTE VEEAVQECRN
1750
1751
AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKKNMEQTI KDLQHRLDEA
1800
1801
EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL
1850
1851
TYQTEEDRKN LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ
1900
1901
HELDEAEERA DIAESQVNKL RAKSRDIGTK GLNEE                
1935
 

Show the unformatted sequence.

Checksums:
CRC64:C58B22F914215718
MD5:cb98663108c95631d54abe30b4b32652

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Myosin_head 87 - 766 4DB1 A 87 - 766 Jmol OpenAstexViewer
B 87 - 766 Jmol OpenAstexViewer
4P7H A 87 - 766 Jmol OpenAstexViewer
B 87 - 766 Jmol OpenAstexViewer
4PA0 A 87 - 766 Jmol OpenAstexViewer
B 87 - 766 Jmol OpenAstexViewer
Myosin_N 34 - 73 4DB1 A 34 - 73 Jmol OpenAstexViewer
B 34 - 73 Jmol OpenAstexViewer
4P7H A 34 - 73 Jmol OpenAstexViewer
B 34 - 73 Jmol OpenAstexViewer
4PA0 A 34 - 73 Jmol OpenAstexViewer
B 34 - 73 Jmol OpenAstexViewer
Myosin_tail_1 1173 - 1238 4XA1 D 1173 - 1238 Jmol OpenAstexViewer
1173 - 1272 4XA1 A 1173 - 244 Jmol OpenAstexViewer
B 1173 - 244 Jmol OpenAstexViewer
C 1173 - 244 Jmol OpenAstexViewer
1361 - 1425 4XA3 A 1361 - 1425 Jmol OpenAstexViewer
B 1361 - 1425 Jmol OpenAstexViewer
1526 - 1570 5CJ1 G 1526 - 1570 Jmol OpenAstexViewer
1526 - 1571 5CJ1 A 1526 - 1571 Jmol OpenAstexViewer
B 1526 - 1571 Jmol OpenAstexViewer
C 1526 - 1571 Jmol OpenAstexViewer
D 1526 - 1571 Jmol OpenAstexViewer
E 1526 - 1571 Jmol OpenAstexViewer
F 1526 - 1571 Jmol OpenAstexViewer
H 1526 - 1571 Jmol OpenAstexViewer
1551 - 1602 4XA4 B 1551 - 1602 Jmol OpenAstexViewer
1551 - 1603 4XA4 A 1551 - 1603 Jmol OpenAstexViewer
1562 - 1608 5CJ4 B 1562 - 1608 Jmol OpenAstexViewer
1562 - 1612 5CJ4 D 1562 - 1612 Jmol OpenAstexViewer
1562 - 1615 5CJ4 A 1562 - 1615 Jmol OpenAstexViewer
1562 - 1619 5CJ4 C 1562 - 1619 Jmol OpenAstexViewer
1590 - 1657 5CHX A 1590 - 1657 Jmol OpenAstexViewer
B 1590 - 1657 Jmol OpenAstexViewer
1631 - 1689 5CJ0 A 1631 - 1689 Jmol OpenAstexViewer
B 1631 - 1689 Jmol OpenAstexViewer
1777 - 1855 4XA6 A 1777 - 1855 Jmol OpenAstexViewer
1777 - 1901 4XA6 B 1777 - 247 Jmol OpenAstexViewer
1781 - 1903 4XA6 C 1781 - 249 Jmol OpenAstexViewer
1791 - 1855 4XA6 D 1791 - 1855 Jmol OpenAstexViewer
843 - 961 2FXO B 843 - 961 Jmol OpenAstexViewer
3DTP A 854 - 972 Jmol OpenAstexViewer
843 - 962 2FXO C 843 - 962 Jmol OpenAstexViewer
843 - 963 2FXM A 843 - 963 Jmol OpenAstexViewer
2FXO A 843 - 963 Jmol OpenAstexViewer
D 843 - 963 Jmol OpenAstexViewer
3DTP B 854 - 974 Jmol OpenAstexViewer
850 - 961 2FXM B 850 - 961 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.