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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: XRCC6_HUMAN (P12956)

Summary

This is the summary of UniProt entry XRCC6_HUMAN (P12956).

Description: X-ray repair cross-complementing protein 6 EC=3.6.4.- EC=4.2.99.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 609 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 7 27
low_complexity n/a 10 24
Pfam Ku_N 37 256
low_complexity n/a 119 132
disorder n/a 177 187
coiled_coil n/a 239 259
low_complexity n/a 251 264
Pfam Ku 263 468
disorder n/a 297 300
low_complexity n/a 326 337
Pfam Ku_C 472 557
disorder n/a 536 564
Pfam SAP 573 607

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12956. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSGWESYYKT EGDEEAEEEQ EENLEASGDY KYSGRDSLIF LVDASKAMFE
50
51
SQSEDELTPF DMSIQCIQSV YISKIISSDR DLLAVVFYGT EKDKNSVNFK
100
101
NIYVLQELDN PGAKRILELD QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC
150
151
ANLFSDVQFK MSHKRIMLFT NEDNPHGNDS AKASRARTKA GDLRDTGIFL
200
201
DLMHLKKPGG FDISLFYRDI ISIAEDEDLR VHFEESSKLE DLLRKVRAKE
250
251
TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR ETNEPVKTKT
300
301
RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF
350
351
KPLVLLKKHH YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY
400
401
TPRRNIPPYF VALVPQEEEL DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE
450
451
KIMATPEQVG KMKAIVEKLR FTYRSDSFEN PVLQQHFRNL EALALDLMEP
500
501
EQAVDLTLPK VEAMNKRLGS LVDEFKELVY PPDYNPEGKV TKRKHDNEGS
550
551
GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL KSGLKKQELL
600
601
EALTKHFQD                                             
609
 

Show the unformatted sequence.

Checksums:
CRC64:BBD3CD434526DFCB
MD5:c878cb934628beb790924ec9673cd034

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ku 263 - 468 1JEQ A 263 - 468 Jmol OpenAstexViewer
1JEY A 263 - 468 Jmol OpenAstexViewer
5Y3R A 263 - 468 Jmol OpenAstexViewer
6ERF A 263 - 468 Jmol OpenAstexViewer
C 263 - 468 Jmol OpenAstexViewer
E 263 - 468 Jmol OpenAstexViewer
G 263 - 468 Jmol OpenAstexViewer
6ERG A 263 - 468 Jmol OpenAstexViewer
D 263 - 468 Jmol OpenAstexViewer
6ERH A 263 - 468 Jmol OpenAstexViewer
C 263 - 468 Jmol OpenAstexViewer
Ku_C 472 - 534 1JEY A 472 - 534 Jmol OpenAstexViewer
5Y3R A 472 - 534 Jmol OpenAstexViewer
6ERF G 472 - 534 Jmol OpenAstexViewer
6ERG A 472 - 534 Jmol OpenAstexViewer
D 472 - 534 Jmol OpenAstexViewer
6ERH A 472 - 534 Jmol OpenAstexViewer
C 472 - 534 Jmol OpenAstexViewer
472 - 535 6ERF A 472 - 535 Jmol OpenAstexViewer
E 472 - 535 Jmol OpenAstexViewer
472 - 538 1JEQ A 472 - 538 Jmol OpenAstexViewer
6ERF C 472 - 538 Jmol OpenAstexViewer
547 - 557 3RZX B 547 - 557 Jmol OpenAstexViewer
Ku_N 37 - 256 1JEQ A 37 - 256 Jmol OpenAstexViewer
1JEY A 37 - 256 Jmol OpenAstexViewer
5Y3R A 37 - 256 Jmol OpenAstexViewer
6ERF A 37 - 256 Jmol OpenAstexViewer
C 37 - 256 Jmol OpenAstexViewer
E 37 - 256 Jmol OpenAstexViewer
G 37 - 256 Jmol OpenAstexViewer
6ERG A 37 - 256 Jmol OpenAstexViewer
D 37 - 256 Jmol OpenAstexViewer
6ERH A 37 - 256 Jmol OpenAstexViewer
C 37 - 256 Jmol OpenAstexViewer
SAP 573 - 607 1JEQ A 573 - 607 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.