Summary
This is the summary of UniProt entry BMP1_HUMAN (P13497).
Description: | Bone morphogenetic protein 1 EC=3.4.24.19 |
Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
Length: | 986 amino acids |
Reference Proteome: |
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Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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Source | Domain | Start | End |
---|---|---|---|
sig_p | n/a | 1 | 22 |
low_complexity | n/a | 5 | 22 |
disorder | n/a | 26 | 29 |
disorder | n/a | 83 | 117 |
low_complexity | n/a | 105 | 124 |
disorder | n/a | 120 | 125 |
Pfam | Astacin | 128 | 321 |
disorder | n/a | 232 | 237 |
Pfam | CUB | 322 | 431 |
Pfam | CUB | 435 | 544 |
Pfam | FXa_inhibition | 551 | 587 |
Pfam | CUB | 591 | 700 |
Pfam | EGF_CA | 703 | 743 |
Pfam | CUB | 747 | 856 |
disorder | n/a | 758 | 761 |
Pfam | CUB | 860 | 973 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P13497. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
Sequence: | 1
MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA
50 51
AFLGDIALDE EDLRAFQVQQ AVDLRRHTAR KSSIKAAVPG NTSTPSCQST
100 101
NGQPQRGACG RWRGRSRSRR AATSRPERVW PDGVIPFVIG GNFTGSQRAV
150 151
FRQAMRHWEK HTCVTFLERT DEDSYIVFTY RPCGCCSYVG RRGGGPQAIS
200 201
IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN IQPGQEYNFL
250 251
KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG
300 301
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW
350 351
RISVTPGEKI ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK
400 401
LPEPIVSTDS RLWVEFRSSS NWVGKGFFAV YEAICGGDVK KDYGHIQSPN
450 451
YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF EIERHDSCAY DYLEVRDGHS
500 501
ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF AVNFFKEVDE
550 551
CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG
600 601
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE
650 651
VRSGLTADSK LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF
700 701
FSDKDECSKD NGGCQQDCVN TFGSYECQCR SGFVLHDNKH DCKEAGCDHK
750 751
VTSTSGTITS PNWPDKYPSK KECTWAISST PGHRVKLTFM EMDIESQPEC
800 801
AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR FYSDNSVQRK
850 851
GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY
900 901
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA
950 951
GDSVLVKFHS DDTITKKGFH LRYTSTKFQD TLHSRK
986
Show the unformatted sequence. |
Checksums: |
CRC64:F89201913AC3CBEA
MD5:ee9cddca84c66d7fb465cc609fd0dccd
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
---|---|---|---|---|---|
Astacin | 128 - 320 | 6BSL | B | 8 - 200 | Jmol OpenAstexViewer |
6BSM | A | 8 - 200 | Jmol OpenAstexViewer | ||
6BTO | B | 8 - 200 | Jmol OpenAstexViewer | ||
6BTP | A | 8 - 200 | Jmol OpenAstexViewer | ||
B | 8 - 200 | Jmol OpenAstexViewer | |||
128 - 321 | 3EDG | A | 8 - 200 | Jmol OpenAstexViewer | |
3EDH | A | 8 - 200 | Jmol OpenAstexViewer | ||
6BSL | A | 8 - 201 | Jmol OpenAstexViewer | ||
6BTN | A | 8 - 201 | Jmol OpenAstexViewer | ||
B | 8 - 201 | Jmol OpenAstexViewer | |||
6BTO | A | 8 - 201 | Jmol OpenAstexViewer | ||
6BTQ | A | 8 - 201 | Jmol OpenAstexViewer | ||
B | 8 - 201 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.