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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EF2_HUMAN (P13639)

Summary

This is the summary of UniProt entry EF2_HUMAN (P13639).

Description: Elongation factor 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 858 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam GTP_EFTU 17 360
low_complexity n/a 127 137
low_complexity n/a 164 174
disorder n/a 247 248
disorder n/a 276 278
Pfam GTP_EFTU_D2 409 486
Pfam EFG_III 501 568
Pfam EFG_IV 620 737
Pfam EFG_C 739 828
disorder n/a 830 834
disorder n/a 836 839

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P13639. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVNFTVDQIR AIMDKKANIR NMSVIAHVDH GKSTLTDSLV CKAGIIASAR
50
51
AGETRFTDTR KDEQERCITI KSTAISLFYE LSENDLNFIK QSKDGAGFLI
100
101
NLIDSPGHVD FSSEVTAALR VTDGALVVVD CVSGVCVQTE TVLRQAIAER
150
151
IKPVLMMNKM DRALLELQLE PEELYQTFQR IVENVNVIIS TYGEGESGPM
200
201
GNIMIDPVLG TVGFGSGLHG WAFTLKQFAE MYVAKFAAKG EGQLGPAERA
250
251
KKVEDMMKKL WGDRYFDPAN GKFSKSATSP EGKKLPRTFC QLILDPIFKV
300
301
FDAIMNFKKE ETAKLIEKLD IKLDSEDKDK EGKPLLKAVM RRWLPAGDAL
350
351
LQMITIHLPS PVTAQKYRCE LLYEGPPDDE AAMGIKSCDP KGPLMMYISK
400
401
MVPTSDKGRF YAFGRVFSGL VSTGLKVRIM GPNYTPGKKE DLYLKPIQRT
450
451
ILMMGRYVEP IEDVPCGNIV GLVGVDQFLV KTGTITTFEH AHNMRVMKFS
500
501
VSPVVRVAVE AKNPADLPKL VEGLKRLAKS DPMVQCIIEE SGEHIIAGAG
550
551
ELHLEICLKD LEEDHACIPI KKSDPVVSYR ETVSEESNVL CLSKSPNKHN
600
601
RLYMKARPFP DGLAEDIDKG EVSARQELKQ RARYLAEKYE WDVAEARKIW
650
651
CFGPDGTGPN ILTDITKGVQ YLNEIKDSVV AGFQWATKEG ALCEENMRGV
700
701
RFDVHDVTLH ADAIHRGGGQ IIPTARRCLY ASVLTAQPRL MEPIYLVEIQ
750
751
CPEQVVGGIY GVLNRKRGHV FEESQVAGTP MFVVKAYLPV NESFGFTADL
800
801
RSNTGGQAFP QCVFDHWQIL PGDPFDNSSR PSQVVAETRK RKGLKEGIPA
850
851
LDNFLDKL                                              
858
 

Show the unformatted sequence.

Checksums:
CRC64:78BD1710236C0D9C
MD5:e4e239ec473ac3b71fe62a531e35a29b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EFG_C 739 - 828 4V6X Az 739 - 828 Show 3D Structure View in InterPro
6D9J 9 739 - 828 Show 3D Structure View in InterPro
6Z6M CB 739 - 828 Show 3D Structure View in InterPro
6Z6N CB 739 - 828 Show 3D Structure View in InterPro
EFG_III 501 - 568 4V6X Az 501 - 568 Show 3D Structure View in InterPro
6D9J 9 501 - 568 Show 3D Structure View in InterPro
6Z6M CB 501 - 568 Show 3D Structure View in InterPro
6Z6N CB 501 - 568 Show 3D Structure View in InterPro
EFG_IV 620 - 737 4V6X Az 620 - 737 Show 3D Structure View in InterPro
6D9J 9 620 - 737 Show 3D Structure View in InterPro
6Z6M CB 620 - 737 Show 3D Structure View in InterPro
6Z6N CB 620 - 737 Show 3D Structure View in InterPro
GTP_EFTU 17 - 360 4V6X Az 17 - 360 Show 3D Structure View in InterPro
6D9J 9 17 - 360 Show 3D Structure View in InterPro
6Z6M CB 17 - 360 Show 3D Structure View in InterPro
6Z6N CB 17 - 360 Show 3D Structure View in InterPro
GTP_EFTU_D2 409 - 486 4V6X Az 409 - 486 Show 3D Structure View in InterPro
6D9J 9 409 - 486 Show 3D Structure View in InterPro
6Z6M CB 409 - 486 Show 3D Structure View in InterPro
6Z6N CB 409 - 486 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;