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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KAP2_HUMAN (P13861)

Summary

This is the summary of UniProt entry KAP2_HUMAN (P13861).

Description: cAMP-dependent protein kinase type II-alpha regulatory subunit
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 404 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 2
disorder n/a 4 5
Pfam RIIa 8 45
disorder n/a 15 21
disorder n/a 45 89
low_complexity n/a 76 91
disorder n/a 99 125
Pfam cNMP_binding 157 244
Pfam cNMP_binding 279 373
disorder n/a 321 323

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P13861. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL
50
51
PAATPRQSLG HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV
100
101
CAETYNPDEE EEDTDPRVIH PKTDEQRCRL QEACKDILLF KNLDQEQLSQ
150
151
VLDAMFERIV KADEHVIDQG DDGDNFYVIE RGTYDILVTK DNQTRSVGQY
200
201
DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI IVKNNAKKRK
250
251
MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QGEKADSFYI
300
301
IESGEVSILI RSRTKSNKDG GNQEVEIARC HKGQYFGELA LVTNKPRAAS
350
351
AYAVGDVKCL VMDVQAFERL LGPCMDIMKR NISHYEEQLV KMFGSSVDLG
400
401
NLGQ                                                  
404
 

Show the unformatted sequence.

Checksums:
CRC64:C7D6E8E476E1DB65
MD5:77a118e12cf5e40eceac80b617217211

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RIIa 8 - 43 5XBY A 7 - 42 Jmol OpenAstexViewer
8 - 44 2IZX A 7 - 43 Jmol OpenAstexViewer
B 7 - 43 Jmol OpenAstexViewer
4ZP3 A 7 - 43 Jmol OpenAstexViewer
B 7 - 43 Jmol OpenAstexViewer
C 7 - 43 Jmol OpenAstexViewer
D 7 - 43 Jmol OpenAstexViewer
E 7 - 43 Jmol OpenAstexViewer
F 7 - 43 Jmol OpenAstexViewer
G 7 - 43 Jmol OpenAstexViewer
H 7 - 43 Jmol OpenAstexViewer
I 7 - 43 Jmol OpenAstexViewer
J 7 - 43 Jmol OpenAstexViewer
K 7 - 43 Jmol OpenAstexViewer
L 7 - 43 Jmol OpenAstexViewer
5XBY B 7 - 43 Jmol OpenAstexViewer
C 7 - 43 Jmol OpenAstexViewer
D 7 - 43 Jmol OpenAstexViewer
8 - 45 2KYG A 7 - 44 Jmol OpenAstexViewer
B 7 - 44 Jmol OpenAstexViewer
5H77 A 5 - 42 Jmol OpenAstexViewer
B 5 - 42 Jmol OpenAstexViewer
C 5 - 42 Jmol OpenAstexViewer
D 5 - 42 Jmol OpenAstexViewer
E 5 - 42 Jmol OpenAstexViewer
F 5 - 42 Jmol OpenAstexViewer
G 5 - 42 Jmol OpenAstexViewer
H 5 - 42 Jmol OpenAstexViewer
I 5 - 42 Jmol OpenAstexViewer
J 5 - 42 Jmol OpenAstexViewer
K 5 - 42 Jmol OpenAstexViewer
L 5 - 42 Jmol OpenAstexViewer
5H78 A 7 - 44 Jmol OpenAstexViewer
B 7 - 44 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.