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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LYAM1_HUMAN (P14151)

Summary

This is the summary of UniProt entry LYAM1_HUMAN (P14151).

Description: L-selectin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 372 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Lectin_C 46 157
disorder n/a 111 116
Pfam Sushi 197 254
low_complexity n/a 216 227
Pfam Sushi 259 316
transmembrane n/a 334 355
low_complexity n/a 355 366
disorder n/a 369 371

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P14151. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW
50
51
QRARRFCRDN YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW
100
101
VGTNKSLTEE AENWGDGEPN NKKNKEDCVE IYIKRNKDAG KWNDDACHKL
150
151
KAALCYTASC QPWSCSGHGE CVEIINNYTC NCDVGYYGPQ CQFVIQCEPL
200
201
EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT CGPFGNWSSP
250
251
EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK
300
301
TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF
350
351
IIWLARRLKK GKKSKRSMND PY                              
372
 

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Checksums:
CRC64:6EA9918ECA2D3643
MD5:8aa5687c0f3f296f5e8ca366890ddb11

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Lectin_C 46 - 157 3CFW A 8 - 119 Jmol OpenAstexViewer
5VC1 A 8 - 119 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.