Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
28  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HGF_HUMAN (P14210)

Summary

This is the summary of UniProt entry HGF_HUMAN (P14210).

Description: Hepatocyte growth factor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 728 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 31
low_complexity n/a 5 25
Pfam PAN_1 40 124
Pfam Kringle 128 206
Pfam Kringle 211 288
disorder n/a 246 247
disorder n/a 257 258
disorder n/a 299 301
Pfam Kringle 305 383
Pfam Kringle 391 469
Pfam Trypsin 495 716

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P14210. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL
50
51
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP
100
101
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ
150
151
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV
200
201
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY
250
251
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL
300
301
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR
350
351
ENYCRNPDGS ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM
400
401
GNLSQTRSGL TCSMWDKNME DLHRHIFWEP DASKLNENYC RNPDDDAHGP
450
451
WCYTGNPLIP WDYCPISRCE GDTTPTIVNL DHPVISCAKT KQLRVVNGIP
500
501
TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI
550
551
HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP
600
601
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV
650
651
TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP
700
701
NRPGIFVRVA YYAKWIHKII LTYKVPQS                        
728
 

Show the unformatted sequence.

Checksums:
CRC64:2D997938295ADD2F
MD5:bcbb919ab78fa2e713304407def5d7ab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Kringle 128 - 206 1BHT A 128 - 206 Jmol OpenAstexViewer
B 428 - 506 Jmol OpenAstexViewer
1GMN A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
1GMO A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
C 128 - 206 Jmol OpenAstexViewer
D 128 - 206 Jmol OpenAstexViewer
E 128 - 206 Jmol OpenAstexViewer
F 128 - 206 Jmol OpenAstexViewer
G 128 - 206 Jmol OpenAstexViewer
H 128 - 206 Jmol OpenAstexViewer
1GP9 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
C 128 - 206 Jmol OpenAstexViewer
D 128 - 206 Jmol OpenAstexViewer
1NK1 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
2QJ2 A 128 - 206 Jmol OpenAstexViewer
B 1128 - 1206 Jmol OpenAstexViewer
3HN4 A 128 - 206 Jmol OpenAstexViewer
3MKP A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
C 128 - 206 Jmol OpenAstexViewer
D 128 - 206 Jmol OpenAstexViewer
3SP8 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
4D3C A 128 - 206 Jmol OpenAstexViewer
5COE A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CP9 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CS1 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CS3 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CS5 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CS9 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CSQ A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CT1 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CT2 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
5CT3 A 128 - 206 Jmol OpenAstexViewer
B 128 - 206 Jmol OpenAstexViewer
211 - 288 3HN4 A 211 - 288 Jmol OpenAstexViewer
3SP8 A 211 - 288 Jmol OpenAstexViewer
B 211 - 288 Jmol OpenAstexViewer
PAN_1 40 - 124 1BHT A 40 - 124 Jmol OpenAstexViewer
B 340 - 424 Jmol OpenAstexViewer
1GMN A 40 - 124 Jmol OpenAstexViewer
1GMO A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
C 40 - 124 Jmol OpenAstexViewer
D 40 - 124 Jmol OpenAstexViewer
E 40 - 124 Jmol OpenAstexViewer
F 40 - 124 Jmol OpenAstexViewer
G 40 - 124 Jmol OpenAstexViewer
H 40 - 124 Jmol OpenAstexViewer
1GP9 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
C 40 - 124 Jmol OpenAstexViewer
D 40 - 124 Jmol OpenAstexViewer
1NK1 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
2HGF A 40 - 124 Jmol OpenAstexViewer
2QJ2 A 40 - 124 Jmol OpenAstexViewer
B 1040 - 1124 Jmol OpenAstexViewer
3HMS A 40 - 124 Jmol OpenAstexViewer
3HMT A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
3HN4 A 40 - 124 Jmol OpenAstexViewer
3MKP A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
C 40 - 124 Jmol OpenAstexViewer
D 40 - 124 Jmol OpenAstexViewer
3SP8 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
4D3C A 40 - 124 Jmol OpenAstexViewer
5COE A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CP9 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CS1 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CS3 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CS5 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CS9 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CSQ A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CT1 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CT2 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
5CT3 A 40 - 124 Jmol OpenAstexViewer
B 40 - 124 Jmol OpenAstexViewer
42 - 124 1GMN B 42 - 124 Jmol OpenAstexViewer
Trypsin 495 - 716 1SHY A 495 - 716 Jmol OpenAstexViewer
1SI5 H 495 - 716 Jmol OpenAstexViewer
4K3J A 495 - 716 Jmol OpenAstexViewer
504 - 716 4O3T A 504 - 716 Jmol OpenAstexViewer
4O3U A 504 - 716 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.