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36  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HGF_HUMAN (P14210)

Summary

This is the summary of UniProt entry HGF_HUMAN (P14210).

Description: Hepatocyte growth factor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 728 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 31
low_complexity n/a 6 26
Pfam PAN_1 40 124
Pfam Kringle 128 206
Pfam Kringle 211 288
disorder n/a 246 247
disorder n/a 257 258
disorder n/a 299 301
Pfam Kringle 305 383
Pfam Kringle 391 469
Pfam Trypsin 495 716

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P14210. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL
50
51
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP
100
101
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ
150
151
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV
200
201
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY
250
251
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL
300
301
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR
350
351
ENYCRNPDGS ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM
400
401
GNLSQTRSGL TCSMWDKNME DLHRHIFWEP DASKLNENYC RNPDDDAHGP
450
451
WCYTGNPLIP WDYCPISRCE GDTTPTIVNL DHPVISCAKT KQLRVVNGIP
500
501
TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI
550
551
HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP
600
601
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV
650
651
TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP
700
701
NRPGIFVRVA YYAKWIHKII LTYKVPQS                        
728
 

Show the unformatted sequence.

Checksums:
CRC64:2D997938295ADD2F
MD5:bcbb919ab78fa2e713304407def5d7ab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Kringle 128 - 206 1BHT A 128 - 206 Show 3D Structure View in InterPro
B 428 - 506 Show 3D Structure View in InterPro
1GMN A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
1GMO A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
C 128 - 206 Show 3D Structure View in InterPro
D 128 - 206 Show 3D Structure View in InterPro
E 128 - 206 Show 3D Structure View in InterPro
F 128 - 206 Show 3D Structure View in InterPro
G 128 - 206 Show 3D Structure View in InterPro
H 128 - 206 Show 3D Structure View in InterPro
1GP9 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
C 128 - 206 Show 3D Structure View in InterPro
D 128 - 206 Show 3D Structure View in InterPro
1NK1 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
2QJ2 A 128 - 206 Show 3D Structure View in InterPro
B 1128 - 1206 Show 3D Structure View in InterPro
3HN4 A 128 - 206 Show 3D Structure View in InterPro
3MKP A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
C 128 - 206 Show 3D Structure View in InterPro
D 128 - 206 Show 3D Structure View in InterPro
3SP8 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
4D3C A 128 - 206 Show 3D Structure View in InterPro
5COE A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CP9 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CS1 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CS3 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CS5 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CS9 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CSQ A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CT1 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CT2 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
5CT3 A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
7MO7 A 128 - 206 Show 3D Structure View in InterPro
7MO8 A 128 - 206 Show 3D Structure View in InterPro
7MO9 A 128 - 206 Show 3D Structure View in InterPro
7MOA A 128 - 206 Show 3D Structure View in InterPro
D 128 - 206 Show 3D Structure View in InterPro
7MOB A 128 - 206 Show 3D Structure View in InterPro
B 128 - 206 Show 3D Structure View in InterPro
7OCL A 6 - 84 Show 3D Structure View in InterPro
B 6 - 84 Show 3D Structure View in InterPro
7OCM A 6 - 84 Show 3D Structure View in InterPro
211 - 288 3HN4 A 211 - 288 Show 3D Structure View in InterPro
3SP8 A 211 - 288 Show 3D Structure View in InterPro
B 211 - 288 Show 3D Structure View in InterPro
7MO7 A 211 - 288 Show 3D Structure View in InterPro
7MO8 A 211 - 288 Show 3D Structure View in InterPro
7MO9 A 211 - 288 Show 3D Structure View in InterPro
7MOA A 211 - 288 Show 3D Structure View in InterPro
D 211 - 288 Show 3D Structure View in InterPro
7OCL A 89 - 167 Show 3D Structure View in InterPro
B 89 - 167 Show 3D Structure View in InterPro
7OCM A 89 - 167 Show 3D Structure View in InterPro
305 - 383 7MO7 A 305 - 383 Show 3D Structure View in InterPro
7MO8 A 305 - 383 Show 3D Structure View in InterPro
7MOA D 305 - 383 Show 3D Structure View in InterPro
391 - 469 7MO7 A 391 - 469 Show 3D Structure View in InterPro
D 391 - 469 Show 3D Structure View in InterPro
7MO8 A 391 - 469 Show 3D Structure View in InterPro
7MO9 D 391 - 469 Show 3D Structure View in InterPro
7MOA D 391 - 469 Show 3D Structure View in InterPro
PAN_1 40 - 124 1BHT A 40 - 124 Show 3D Structure View in InterPro
B 340 - 424 Show 3D Structure View in InterPro
1GMN A 40 - 124 Show 3D Structure View in InterPro
1GMO A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
C 40 - 124 Show 3D Structure View in InterPro
D 40 - 124 Show 3D Structure View in InterPro
E 40 - 124 Show 3D Structure View in InterPro
F 40 - 124 Show 3D Structure View in InterPro
G 40 - 124 Show 3D Structure View in InterPro
H 40 - 124 Show 3D Structure View in InterPro
1GP9 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
C 40 - 124 Show 3D Structure View in InterPro
D 40 - 124 Show 3D Structure View in InterPro
1NK1 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
2HGF A 40 - 124 Show 3D Structure View in InterPro
2QJ2 A 40 - 124 Show 3D Structure View in InterPro
B 1040 - 1124 Show 3D Structure View in InterPro
3HMS A 40 - 124 Show 3D Structure View in InterPro
3HMT A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
3HN4 A 40 - 124 Show 3D Structure View in InterPro
3MKP A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
C 40 - 124 Show 3D Structure View in InterPro
D 40 - 124 Show 3D Structure View in InterPro
3SP8 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
4D3C A 40 - 124 Show 3D Structure View in InterPro
5COE A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CP9 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CS1 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CS3 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CS5 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CS9 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CSQ A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CT1 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CT2 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
5CT3 A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
7MO7 A 40 - 124 Show 3D Structure View in InterPro
7MO8 A 40 - 124 Show 3D Structure View in InterPro
7MO9 A 40 - 124 Show 3D Structure View in InterPro
7MOA A 40 - 124 Show 3D Structure View in InterPro
D 40 - 124 Show 3D Structure View in InterPro
7MOB A 40 - 124 Show 3D Structure View in InterPro
B 40 - 124 Show 3D Structure View in InterPro
42 - 124 1GMN B 42 - 124 Show 3D Structure View in InterPro
Trypsin 495 - 716 1SHY A 495 - 716 Show 3D Structure View in InterPro
1SI5 H 495 - 716 Show 3D Structure View in InterPro
4K3J A 495 - 716 Show 3D Structure View in InterPro
6LZ9 B 495 - 716 Show 3D Structure View in InterPro
7MO7 A 495 - 716 Show 3D Structure View in InterPro
D 495 - 716 Show 3D Structure View in InterPro
7MO8 A 495 - 716 Show 3D Structure View in InterPro
7MO9 D 495 - 716 Show 3D Structure View in InterPro
7MOA D 495 - 716 Show 3D Structure View in InterPro
504 - 716 4O3T A 504 - 716 Show 3D Structure View in InterPro
4O3U A 504 - 716 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;