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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TOP3_ECOLI (P14294)

Summary

This is the summary of UniProt entry TOP3_ECOLI (P14294).

Description: DNA topoisomerase 3 {ECO:0000255|HAMAP-Rule:MF_00953}
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
View Pfam proteome data.
Length: 653 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Toprim 2 137
Pfam Topoisom_bac 153 593
disorder n/a 277 278
low_complexity n/a 355 366
disorder n/a 452 455
disorder n/a 460 463
disorder n/a 478 479
disorder n/a 484 486
disorder n/a 558 562
disorder n/a 572 574
disorder n/a 613 620
disorder n/a 622 653
low_complexity n/a 624 643

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P14294. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRLFIAEKPS LARAIADVLP KPHRKGDGFI ECGNGQVVTW CIGHLLEQAQ
50
51
PDAYDSRYAR WNLADLPIVP EKWQLQPRPS VTKQLNVIKR FLHEASEIVH
100
101
AGDPDREGQL LVDEVLDYLQ LAPEKRQQVQ RCLINDLNPQ AVERAIDRLR
150
151
SNSEFVPLCV SALARARADW LYGINMTRAY TILGRNAGYQ GVLSVGRVQT
200
201
PVLGLVVRRD EEIENFVAKD FFEVKAHIVT PADERFTAIW QPSEACEPYQ
250
251
DEEGRLLHRP LAEHVVNRIS GQPAIVTSYN DKRESESAPL PFSLSALQIE
300
301
AAKRFGLSAQ NVLDICQKLY ETHKLITYPR SDCRYLPEEH FAGRHAVMNA
350
351
ISVHAPDLLP QPVVDPDIRN RCWDDKKVDA HHAIIPTARS SAINLTENEA
400
401
KVYNLIARQY LMQFCPDAVF RKCVIELDIA KGKFVAKARF LAEAGWRTLL
450
451
GSKERDEEND GTPLPVVAKG DELLCEKGEV VERQTQPPRH FTDATLLSAM
500
501
TGIARFVQDK DLKKILRATD GLGTEATRAG IIELLFKRGF LTKKGRYIHS
550
551
TDAGKALFHS LPEMATRPDM TAHWESVLTQ ISEKQCRYQD FMQPLVGTLY
600
601
QLIDQAKRTP VRQFRGIVAP GSGGSADKKK AAPRKRSAKK SPPADEVGSG
650
651
AIA                                                   
653
 

Show the unformatted sequence.

Checksums:
CRC64:301566E14DDDD8C7
MD5:9c398b236aac30be7e202dcd1dfd3a2a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Topoisom_bac 153 - 593 1D6M A 153 - 593 Jmol OpenAstexViewer
1I7D A 153 - 593 Jmol OpenAstexViewer
2O19 A 153 - 593 Jmol OpenAstexViewer
B 153 - 593 Jmol OpenAstexViewer
2O54 A 153 - 593 Jmol OpenAstexViewer
B 153 - 593 Jmol OpenAstexViewer
2O59 A 153 - 593 Jmol OpenAstexViewer
B 153 - 593 Jmol OpenAstexViewer
2O5C A 153 - 593 Jmol OpenAstexViewer
B 153 - 593 Jmol OpenAstexViewer
2O5E A 153 - 593 Jmol OpenAstexViewer
B 153 - 593 Jmol OpenAstexViewer
Toprim 2 - 137 1D6M A 2 - 137 Jmol OpenAstexViewer
1I7D A 2 - 137 Jmol OpenAstexViewer
2O19 A 2 - 137 Jmol OpenAstexViewer
B 2 - 137 Jmol OpenAstexViewer
2O54 A 2 - 137 Jmol OpenAstexViewer
B 2 - 137 Jmol OpenAstexViewer
2O59 A 2 - 137 Jmol OpenAstexViewer
B 2 - 137 Jmol OpenAstexViewer
2O5C A 2 - 137 Jmol OpenAstexViewer
B 2 - 137 Jmol OpenAstexViewer
2O5E A 2 - 137 Jmol OpenAstexViewer
B 2 - 137 Jmol OpenAstexViewer