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29  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KPYM_HUMAN (P14618)

Summary

This is the summary of UniProt entry KPYM_HUMAN (P14618).

Description: Pyruvate kinase PKM EC=2.7.1.40
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 531 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 4 10
disorder n/a 13 14
Pfam PK 42 395
disorder n/a 336 339
Pfam PK_C 410 528

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P14618. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT
50
51
IGPASRSVET LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS
100
101
DPILYRPVAV ALDTKGPEIR TGLIKGSGTA EVELKKGATL KITLDNAYME
150
151
KCDENILWLD YKNICKVVEV GSKIYVDDGL ISLQVKQKGA DFLVTEVENG
200
201
GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV FASFIRKASD
250
251
VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE
300
301
IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN
350
351
AVLDGADCIM LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR
400
401
LAPITSDPTE ATAVGAVEAS FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI
450
451
IAVTRNPQTA RQAHLYRGIF PVLCKDPVQE AWAEDVDLRV NFAMNVGKAR
500
501
GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P                    
531
 

Show the unformatted sequence.

Checksums:
CRC64:AA94D7818ED6BBAD
MD5:b9f341db7edc1c70c1439f8176ea2889

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PK 42 - 395 1T5A A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
1ZJH A 41 - 394 Jmol OpenAstexViewer
3BJF A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
3BJT A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
3G2G A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
3GQY A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
3GR4 A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
3H6O A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
3ME3 A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
3SRD A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
3SRF A 41 - 394 Jmol OpenAstexViewer
B 41 - 394 Jmol OpenAstexViewer
C 41 - 394 Jmol OpenAstexViewer
D 41 - 394 Jmol OpenAstexViewer
E 41 - 394 Jmol OpenAstexViewer
F 41 - 394 Jmol OpenAstexViewer
G 41 - 394 Jmol OpenAstexViewer
H 41 - 394 Jmol OpenAstexViewer
3SRH A 41 - 394 Jmol OpenAstexViewer
B 41 - 394 Jmol OpenAstexViewer
C 41 - 394 Jmol OpenAstexViewer
D 41 - 394 Jmol OpenAstexViewer
3U2Z A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4B2D A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4FXF A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4FXJ A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4G1N A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4JPG A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4QG6 A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4QG8 A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4QG9 A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4QGC A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4RPP A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4WJ8 A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
4YJ5 A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
5X0I A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
5X1V A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
5X1W A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
C 42 - 395 Jmol OpenAstexViewer
D 42 - 395 Jmol OpenAstexViewer
6B6U A 42 - 395 Jmol OpenAstexViewer
B 42 - 395 Jmol OpenAstexViewer
PK_C 410 - 528 1T5A A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
1ZJH A 409 - 527 Jmol OpenAstexViewer
3BJF A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
3BJT A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
3G2G A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
3GQY A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
3GR4 A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
3H6O A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
3ME3 A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
3SRD A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
3SRF A 409 - 527 Jmol OpenAstexViewer
B 409 - 527 Jmol OpenAstexViewer
C 409 - 527 Jmol OpenAstexViewer
D 409 - 527 Jmol OpenAstexViewer
E 409 - 527 Jmol OpenAstexViewer
F 409 - 527 Jmol OpenAstexViewer
G 409 - 527 Jmol OpenAstexViewer
H 409 - 527 Jmol OpenAstexViewer
3SRH A 409 - 527 Jmol OpenAstexViewer
B 409 - 527 Jmol OpenAstexViewer
C 409 - 527 Jmol OpenAstexViewer
D 409 - 527 Jmol OpenAstexViewer
3U2Z A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4B2D A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4FXF A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4FXJ A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4G1N A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4JPG A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4QG6 A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4QG8 A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4QG9 A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4QGC A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4RPP A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4WJ8 A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
4YJ5 A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
5X0I A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
5X1V A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
5X1W A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer
C 410 - 528 Jmol OpenAstexViewer
D 410 - 528 Jmol OpenAstexViewer
6B6U A 410 - 528 Jmol OpenAstexViewer
B 410 - 528 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.