Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AMPN_HUMAN (P15144)

Summary

This is the summary of UniProt entry AMPN_HUMAN (P15144).

Description: Aminopeptidase N {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 967 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
low_complexity n/a 10 18
transmembrane n/a 12 33
disorder n/a 40 62
low_complexity n/a 40 63
Pfam Peptidase_M1_N 81 279
disorder n/a 140 144
disorder n/a 147 151
disorder n/a 249 252
disorder n/a 254 266
Pfam Peptidase_M1 316 543
low_complexity n/a 372 376
Pfam ERAP1_C 619 946
low_complexity n/a 859 868
coiled_coil n/a 934 954

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P15144. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAKGFYISKS LGILGILLGV AAVCTIIALS VVYSQEKNKN ANSSPVASTT
50
51
PSASATTNPA SATTLDQSKA WNRYRLPNTL KPDSYRVTLR PYLTPNDRGL
100
101
YVFKGSSTVR FTCKEATDVI IIHSKKLNYT LSQGHRVVLR GVGGSQPPDI
150
151
DKTELVEPTE YLVVHLKGSL VKDSQYEMDS EFEGELADDL AGFYRSEYME
200
201
GNVRKVVATT QMQAADARKS FPCFDEPAMK AEFNITLIHP KDLTALSNML
250
251
PKGPSTPLPE DPNWNVTEFH TTPKMSTYLL AFIVSEFDYV EKQASNGVLI
300
301
RIWARPSAIA AGHGDYALNV TGPILNFFAG HYDTPYPLPK SDQIGLPDFN
350
351
AGAMENWGLV TYRENSLLFD PLSSSSSNKE RVVTVIAHEL AHQWFGNLVT
400
401
IEWWNDLWLN EGFASYVEYL GADYAEPTWN LKDLMVLNDV YRVMAVDALA
450
451
SSHPLSTPAS EINTPAQISE LFDAISYSKG ASVLRMLSSF LSEDVFKQGL
500
501
ASYLHTFAYQ NTIYLNLWDH LQEAVNNRSI QLPTTVRDIM NRWTLQMGFP
550
551
VITVDTSTGT LSQEHFLLDP DSNVTRPSEF NYVWIVPITS IRDGRQQQDY
600
601
WLIDVRAQND LFSTSGNEWV LLNLNVTGYY RVNYDEENWR KIQTQLQRDH
650
651
SAIPVINRAQ IINDAFNLAS AHKVPVTLAL NNTLFLIEER QYMPWEAALS
700
701
SLSYFKLMFD RSEVYGPMKN YLKKQVTPLF IHFRNNTNNW REIPENLMDQ
750
751
YSEVNAISTA CSNGVPECEE MVSGLFKQWM ENPNNNPIHP NLRSTVYCNA
800
801
IAQGGEEEWD FAWEQFRNAT LVNEADKLRA ALACSKELWI LNRYLSYTLN
850
851
PDLIRKQDAT STIISITNNV IGQGLVWDFV QSNWKKLFND YGGGSFSFSN
900
901
LIQAVTRRFS TEYELQQLEQ FKKDNEETGF GSGTRALEQA LEKTKANIKW
950
951
VKENKEVVLQ WFTENSK                                    
967
 

Show the unformatted sequence.

Checksums:
CRC64:37B6BC1BF0D6B1F2
MD5:718dcea23d907d229eafe1044262ab5f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ERAP1_C 619 - 946 4FYQ A 619 - 946 Jmol OpenAstexViewer
4FYR A 619 - 946 Jmol OpenAstexViewer
4FYS A 619 - 946 Jmol OpenAstexViewer
4FYT A 619 - 946 Jmol OpenAstexViewer
5LHD A 619 - 946 Jmol OpenAstexViewer
B 619 - 946 Jmol OpenAstexViewer
C 619 - 946 Jmol OpenAstexViewer
D 619 - 946 Jmol OpenAstexViewer
6ATK A 619 - 946 Jmol OpenAstexViewer
B 619 - 946 Jmol OpenAstexViewer
C 619 - 946 Jmol OpenAstexViewer
Peptidase_M1 316 - 543 4FYQ A 316 - 543 Jmol OpenAstexViewer
4FYR A 316 - 543 Jmol OpenAstexViewer
4FYS A 316 - 543 Jmol OpenAstexViewer
4FYT A 316 - 543 Jmol OpenAstexViewer
5LHD A 316 - 543 Jmol OpenAstexViewer
B 316 - 543 Jmol OpenAstexViewer
C 316 - 543 Jmol OpenAstexViewer
D 316 - 543 Jmol OpenAstexViewer
6ATK A 316 - 543 Jmol OpenAstexViewer
B 316 - 543 Jmol OpenAstexViewer
C 316 - 543 Jmol OpenAstexViewer
Peptidase_M1_N 81 - 279 4FYQ A 81 - 279 Jmol OpenAstexViewer
4FYR A 81 - 279 Jmol OpenAstexViewer
4FYS A 81 - 279 Jmol OpenAstexViewer
4FYT A 81 - 279 Jmol OpenAstexViewer
5LHD A 81 - 279 Jmol OpenAstexViewer
B 81 - 279 Jmol OpenAstexViewer
C 81 - 279 Jmol OpenAstexViewer
D 81 - 279 Jmol OpenAstexViewer
6ATK A 81 - 279 Jmol OpenAstexViewer
B 81 - 279 Jmol OpenAstexViewer
C 81 - 279 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.