Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RAC2_HUMAN (P15153)

Summary

This is the summary of UniProt entry RAC2_HUMAN (P15153).

Description: Ras-related C3 botulinum toxin substrate 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 192 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Ras 5 178

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P15153. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP
50
51
VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE
100
101
VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKEID
150
151
SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRACS LL        
192
 

Show the unformatted sequence.

Checksums:
CRC64:2A1F1266B07C3210
MD5:5f081dfe8dea7ec44e30f961966e834d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ras 5 - 176 2W2V B 5 - 176 Jmol OpenAstexViewer
C 5 - 176 Jmol OpenAstexViewer
5 - 177 2W2V A 5 - 177 Jmol OpenAstexViewer
D 5 - 177 Jmol OpenAstexViewer
2W2X A 5 - 177 Jmol OpenAstexViewer
B 5 - 177 Jmol OpenAstexViewer
5 - 178 1DS6 A 5 - 178 Jmol OpenAstexViewer
2W2T A 5 - 178 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.