Summary
This is the summary of UniProt entry INGR1_HUMAN (P15260).
| Description: | Interferon gamma receptor 1 {ECO:0000312|HGNC:HGNC:5439} |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 489 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 17 |
| Pfam | Tissue_fac | 2 | 113 |
| disorder | n/a | 22 | 23 |
| Pfam | IFNGR1 | 161 | 324 |
| transmembrane | n/a | 247 | 270 |
| low_complexity | n/a | 251 | 265 |
| disorder | n/a | 327 | 400 |
| low_complexity | n/a | 373 | 391 |
| disorder | n/a | 402 | 445 |
| low_complexity | n/a | 415 | 429 |
| disorder | n/a | 449 | 451 |
| disorder | n/a | 474 | 485 |
| disorder | n/a | 487 | 489 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P15260. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MALLFLLPLV MQGVSRAEMG TADLGPSSVP TPTNVTIESY NMNPIVYWEY
50 51
QIMPQVPVFT VEVKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV
100 101
RVKARVGQKE SAYAKSEEFA VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV
150 151
FVNGDEQEVD YDPETTCYIR VYNVYVRMNG SEIQYKILTQ KEDDCDEIQC
200 201
QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN SSIKGSLWIP
250 251
VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP
300 301
ESKYVSLITS YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS
350 351
SITEVVTTEE NIPDVVPGSH LTPIERESSS PLSSNQSEPG SIALNSYHSR
400 401
NCSESDHSRN GFDTDSSCLE SHSSLSDSEF PPNNKGEIKT EGQELITVIK
450 451
APTSFGYDKP HVLVDLLVDD SGKESLIGYR PTEDSKEFS
489
Show the unformatted sequence. |
| Checksums: |
CRC64:DCF9E574D8F47400
MD5:8c8fa45122b6315319c5bd98e938be96
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
The parts of the structure corresponding to the Pfam family are highlighted in blue.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
