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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DESP_HUMAN (P15924)

Summary

This is the summary of UniProt entry DESP_HUMAN (P15924).

Description: Desmoplakin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2871 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 2
disorder n/a 12 18
disorder n/a 22 23
disorder n/a 25 31
disorder n/a 41 44
disorder n/a 53 63
disorder n/a 68 69
coiled_coil n/a 135 155
low_complexity n/a 165 178
low_complexity n/a 318 331
coiled_coil n/a 319 339
coiled_coil n/a 411 441
low_complexity n/a 413 432
Pfam SH3_10 447 513
Pfam Spectrin_like 548 625
disorder n/a 602 607
low_complexity n/a 630 646
disorder n/a 634 643
disorder n/a 646 658
low_complexity n/a 810 824
disorder n/a 937 938
coiled_coil n/a 1027 1047
coiled_coil n/a 1055 1096
coiled_coil n/a 1104 1152
disorder n/a 1125 1136
disorder n/a 1139 1141
low_complexity n/a 1158 1171
coiled_coil n/a 1171 1209
disorder n/a 1187 1212
low_complexity n/a 1208 1223
disorder n/a 1217 1242
coiled_coil n/a 1225 1273
disorder n/a 1261 1283
coiled_coil n/a 1288 1365
disorder n/a 1291 1322
disorder n/a 1324 1330
disorder n/a 1345 1347
disorder n/a 1373 1400
coiled_coil n/a 1388 1436
disorder n/a 1402 1404
disorder n/a 1406 1414
disorder n/a 1416 1418
disorder n/a 1420 1453
disorder n/a 1460 1472
coiled_coil n/a 1466 1548
disorder n/a 1476 1477
disorder n/a 1484 1488
disorder n/a 1494 1495
disorder n/a 1497 1498
disorder n/a 1500 1502
disorder n/a 1510 1516
disorder n/a 1521 1523
disorder n/a 1525 1528
coiled_coil n/a 1556 1681
low_complexity n/a 1562 1576
disorder n/a 1579 1582
disorder n/a 1584 1586
disorder n/a 1588 1598
disorder n/a 1626 1627
disorder n/a 1635 1645
disorder n/a 1647 1652
disorder n/a 1655 1656
disorder n/a 1672 1673
disorder n/a 1675 1677
disorder n/a 1679 1684
disorder n/a 1686 1689
coiled_coil n/a 1689 1744
low_complexity n/a 1717 1735
disorder n/a 1735 1738
disorder n/a 1742 1746
coiled_coil n/a 1763 1804
disorder n/a 1795 1796
coiled_coil n/a 1812 1919
disorder n/a 1833 1834
disorder n/a 1840 1841
disorder n/a 1878 1894
low_complexity n/a 1878 1897
low_complexity n/a 1904 1917
disorder n/a 1920 1935
coiled_coil n/a 1925 1945
disorder n/a 1939 1947
disorder n/a 1951 1955
low_complexity n/a 1984 1998
low_complexity n/a 2013 2023
Pfam Plectin 2047 2086
Pfam Plectin 2123 2163
disorder n/a 2170 2171
Pfam Plectin 2252 2292
low_complexity n/a 2287 2296
Pfam Plectin 2290 2330
Pfam Plectin 2366 2406
disorder n/a 2408 2417
Pfam Plectin 2467 2497
low_complexity n/a 2494 2504
low_complexity n/a 2565 2584
low_complexity n/a 2605 2616
Pfam Plectin 2649 2689
Pfam Plectin 2725 2765
disorder n/a 2813 2850
low_complexity n/a 2823 2848
low_complexity n/a 2855 2867

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P15924. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSCNGGSHPR INTLGRMIRA ESGPDLRYEV TSGGGGTSRM YYSRRGVITD
50
51
QNSDGYCQTG TMSRHQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ
100
101
LTRSRELDEC FAQANDQMEI LDSLIREMRQ MGQPCDAYQK RLLQLQEQMR
150
151
ALYKAISVPR VRRASSKGGG GYTCQSGSGW DEFTKHVTSE CLGWMRQQRA
200
201
EMDMVAWGVD LASVEQHINS HRGIHNSIGD YRWQLDKIKA DLREKSAIYQ
250
251
LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE EEELLYDWSD
300
301
KNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ HPASDKIEAY
350
351
MDTLQTQWSW ILQITKCIDV HLKENAAYFQ FFEEAQSTEA YLKGLQDSIR
400
401
KKYPCDKNMP LQHLLEQIKE LEKEREKILE YKRQVQNLVN KSKKIVQLKP
450
451
RNPDYRSNKP IILRALCDYK QDQKIVHKGD ECILKDNNER SKWYVTGPGG
500
501
VDMLVPSVGL IIPPPNPLAV DLSCKIEQYY EAILALWNQL YINMKSLVSW
550
551
HYCMIDIEKI RAMTIAKLKT MRQEDYMKTI ADLELHYQEF IRNSQGSEMF
600
601
GDDDKRKIQS QFTDAQKHYQ TLVIQLPGYP QHQTVTTTEI THHGTCQDVN
650
651
HNKVIETNRE NDKQETWMLM ELQKIRRQIE HCEGRMTLKN LPLADQGSSH
700
701
HITVKINELK SVQNDSQAIA EVLNQLKDML ANFRGSEKYC YLQNEVFGLF
750
751
QKLENINGVT DGYLNSLCTV RALLQAILQT EDMLKVYEAR LTEEETVCLD
800
801
LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS QTSQQYPLYD
850
851
LDLGKFGEKV TQLTDRWQRI DKQIDFRLWD LEKQIKQLRN YRDNYQAFCK
900
901
WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK RDKSEEVQKI
950
951
AELCANSIKD YELQLASYTS GLETLLNIPI KRTMIQSPSG VILQEAADVH
1000
1001
ARYIELLTRS GDYYRFLSEM LKSLEDLKLK NTKIEVLEEE LRLARDANSE
1050
1051
NCNKNKFLDQ NLQKYQAECS QFKAKLASLE ELKRQAELDG KSAKQNLDKC
1100
1101
YGQIKELNEK ITRLTYEIED EKRRRKSVED RFDQQKNDYD QLQKARQCEK
1150
1151
ENLGWQKLES EKAIKEKEYE IERLRVLLQE EGTRKREYEN ELAKVRNHYN
1200
1201
EEMSNLRNKY ETEINITKTT IKEISMQKED DSKNLRNQLD RLSRENRDLK
1250
1251
DEIVRLNDSI LQATEQRRRA EENALQQKAC GSEIMQKKQH LEIELKQVMQ
1300
1301
QRSEDNARHK QSLEEAAKTI QDKNKEIERL KAEFQEEAKR RWEYENELSK
1350
1351
VRNNYDEEII SLKNQFETEI NITKTTIHQL TMQKEEDTSG YRAQIDNLTR
1400
1401
ENRSLSEEIK RLKNTLTQTT ENLRRVEEDI QQQKATGSEV SQRKQQLEVE
1450
1451
LRQVTQMRTE ESVRYKQSLD DAAKTIQDKN KEIERLKQLI DKETNDRKCL
1500
1501
EDENARLQRV QYDLQKANSS ATETINKLKV QEQELTRLRI DYERVSQERT
1550
1551
VKDQDITRFQ NSLKELQLQK QKVEEELNRL KRTASEDSCK RKKLEEELEG
1600
1601
MRRSLKEQAI KITNLTQQLE QASIVKKRSE DDLRQQRDVL DGHLREKQRT
1650
1651
QEELRRLSSE VEALRRQLLQ EQESVKQAHL RNEHFQKAIE DKSRSLNESK
1700
1701
IEIERLQSLT ENLTKEHLML EEELRNLRLE YDDLRRGRSE ADSDKNATIL
1750
1751
ELRSQLQISN NRTLELQGLI NDLQRERENL RQEIEKFQKQ ALEASNRIQE
1800
1801
SKNQCTQVVQ ERESLLVKIK VLEQDKARLQ RLEDELNRAK STLEAETRVK
1850
1851
QRLECEKQQI QNDLNQWKTQ YSRKEEAIRK IESEREKSER EKNSLRSEIE
1900
1901
RLQAEIKRIE ERCRRKLEDS TRETQSQLET ERSRYQREID KLRQRPYGSH
1950
1951
RETQTECEWT VDTSKLVFDG LRKKVTAMQL YECQLIDKTT LDKLLKGKKS
2000
2001
VEEVASEIQP FLRGAGSIAG ASASPKEKYS LVEAKRKKLI SPESTVMLLE
2050
2051
AQAATGGIID PHRNEKLTVD SAIARDLIDF DDRQQIYAAE KAITGFDDPF
2100
2101
SGKTVSVSEA IKKNLIDRET GMRLLEAQIA SGGVVDPVNS VFLPKDVALA
2150
2151
RGLIDRDLYR SLNDPRDSQK NFVDPVTKKK VSYVQLKERC RIEPHTGLLL
2200
2201
LSVQKRSMSF QGIRQPVTVT ELVDSGILRP STVNELESGQ ISYDEVGERI
2250
2251
KDFLQGSSCI AGIYNETTKQ KLGIYEAMKI GLVRPGTALE LLEAQAATGF
2300
2301
IVDPVSNLRL PVEEAYKRGL VGIEFKEKLL SAERAVTGYN DPETGNIISL
2350
2351
FQAMNKELIE KGHGIRLLEA QIATGGIIDP KESHRLPVDI AYKRGYFNEE
2400
2401
LSEILSDPSD DTKGFFDPNT EENLTYLQLK ERCIKDEETG LCLLPLKEKK
2450
2451
KQVQTSQKNT LRKRRVVIVD PETNKEMSVQ EAYKKGLIDY ETFKELCEQE
2500
2501
CEWEEITITG SDGSTRVVLV DRKTGSQYDI QDAIDKGLVD RKFFDQYRSG
2550
2551
SLSLTQFADM ISLKNGVGTS SSMGSGVSDD VFSSSRHESV SKISTISSVR
2600
2601
NLTIRSSSFS DTLEESSPIA AIFDTENLEK ISITEGIERG IVDSITGQRL
2650
2651
LEAQACTGGI IHPTTGQKLS LQDAVSQGVI DQDMATRLKP AQKAFIGFEG
2700
2701
VKGKKKMSAA EAVKEKWLPY EAGQRFLEFQ YLTGGLVDPE VHGRISTEEA
2750
2751
IRKGFIDGRA AQRLQDTSSY AKILTCPKTK LKISYKDAIN RSMVEDITGL
2800
2801
RLLEAASVSS KGLPSPYNMS SAPGSRSGSR SGSRSGSRSG SRSGSRRGSF
2850
2851
DATGNSSYSY SYSFSSSSIG H                               
2871
 

Show the unformatted sequence.

Checksums:
CRC64:5770CC6B4F9F9F7B
MD5:69c2ce4671e721b72833bb1b6e86c4cf

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Plectin 2047 - 2086 5DZZ A 2047 - 2086 Jmol OpenAstexViewer
2123 - 2163 5DZZ A 2123 - 2163 Jmol OpenAstexViewer
2252 - 2292 1LM7 A 2252 - 2292 Jmol OpenAstexViewer
B 2252 - 2292 Jmol OpenAstexViewer
5DZZ A 2252 - 2292 Jmol OpenAstexViewer
2290 - 2330 1LM7 A 2290 - 2330 Jmol OpenAstexViewer
B 2290 - 2330 Jmol OpenAstexViewer
5DZZ A 2290 - 2330 Jmol OpenAstexViewer
2366 - 2406 1LM7 A 2366 - 2406 Jmol OpenAstexViewer
B 2366 - 2406 Jmol OpenAstexViewer
5DZZ A 2366 - 2406 Jmol OpenAstexViewer
2649 - 2689 1LM5 A 2649 - 2689 Jmol OpenAstexViewer
B 2649 - 2689 Jmol OpenAstexViewer
2725 - 2765 1LM5 A 2725 - 2765 Jmol OpenAstexViewer
B 2725 - 2765 Jmol OpenAstexViewer
SH3_10 447 - 513 3R6N A 447 - 513 Jmol OpenAstexViewer
B 447 - 513 Jmol OpenAstexViewer
Spectrin_like 548 - 625 3R6N A 548 - 625 Jmol OpenAstexViewer
B 548 - 625 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.