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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: ACADS_HUMAN (P16219)

Summary

This is the summary of UniProt entry ACADS_HUMAN (P16219).

Description: Short-chain specific acyl-CoA dehydrogenase, mitochondrial EC=1.3.8.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 412 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 15
low_complexity n/a 1 16
Pfam Acyl-CoA_dh_N 35 147
Pfam Acyl-CoA_dh_M 151 246
disorder n/a 163 167
Pfam Acyl-CoA_dh_1 258 407
low_complexity n/a 344 362

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P16219. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAALLARAS GPARRALCPR AWRQLHTIYQ SVELPETHQM LLQTCRDFAE
50
51
KELFPIAAQV DKEHLFPAAQ VKKMGGLGLL AMDVPEELGG AGLDYLAYAI
100
101
AMEEISRGCA STGVIMSVNN SLYLGPILKF GSKEQKQAWV TPFTSGDKIG
150
151
CFALSEPGNG SDAGAASTTA RAEGDSWVLN GTKAWITNAW EASAAVVFAS
200
201
TDRALQNKGI SAFLVPMPTP GLTLGKKEDK LGIRGSSTAN LIFEDCRIPK
250
251
DSILGEPGMG FKIAMQTLDM GRIGIASQAL GIAQTALDCA VNYAENRMAF
300
301
GAPLTKLQVI QFKLADMALA LESARLLTWR AAMLKDNKKP FIKEAAMAKL
350
351
AASEAATAIS HQAIQILGGM GYVTEMPAER HYRDARITEI YEGTSEIQRL
400
401
VIAGHLLRSY RS                                         
412
 

Show the unformatted sequence.

Checksums:
CRC64:3E946ADFC3DA3C0E
MD5:a24397ebf3aa0e7af937952c61b6b80b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Acyl-CoA_dh_1 258 - 407 2VIG A 258 - 407 Jmol OpenAstexViewer
B 258 - 407 Jmol OpenAstexViewer
C 258 - 407 Jmol OpenAstexViewer
D 258 - 407 Jmol OpenAstexViewer
E 258 - 407 Jmol OpenAstexViewer
F 258 - 407 Jmol OpenAstexViewer
G 258 - 407 Jmol OpenAstexViewer
H 258 - 407 Jmol OpenAstexViewer
Acyl-CoA_dh_M 151 - 246 2VIG A 151 - 246 Jmol OpenAstexViewer
B 151 - 246 Jmol OpenAstexViewer
C 151 - 246 Jmol OpenAstexViewer
D 151 - 246 Jmol OpenAstexViewer
E 151 - 246 Jmol OpenAstexViewer
F 151 - 246 Jmol OpenAstexViewer
G 151 - 246 Jmol OpenAstexViewer
H 151 - 246 Jmol OpenAstexViewer
Acyl-CoA_dh_N 35 - 147 2VIG A 35 - 147 Jmol OpenAstexViewer
B 35 - 147 Jmol OpenAstexViewer
C 35 - 147 Jmol OpenAstexViewer
D 35 - 147 Jmol OpenAstexViewer
E 35 - 147 Jmol OpenAstexViewer
F 35 - 147 Jmol OpenAstexViewer
G 35 - 147 Jmol OpenAstexViewer
H 35 - 147 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.