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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: CREB1_HUMAN (P16220)

Summary

This is the summary of UniProt entry CREB1_HUMAN (P16220).

Description: Cyclic AMP-responsive element-binding protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 341 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 58
disorder n/a 64 74
disorder n/a 77 78
disorder n/a 80 84
disorder n/a 89 90
disorder n/a 101 136
low_complexity n/a 106 121
Pfam pKID 113 153
disorder n/a 138 170
low_complexity n/a 151 158
low_complexity n/a 161 173
disorder n/a 194 212
disorder n/a 215 222
disorder n/a 225 227
disorder n/a 253 254
disorder n/a 265 296
Pfam bZIP_1 281 340
low_complexity n/a 291 305
coiled_coil n/a 301 335

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P16220. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA
50
51
PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT
100
101
QISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR
150
151
IEEEKSEEET SAPAITTVTV PTPIYQTSSG QYIAITQGGA IQLANNGTDG
200
201
VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV VVQAASGDVQ
250
251
TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC
300
301
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D         
341
 

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Checksums:
CRC64:D5E989AE40BF69AF
MD5:26d3cc38c364ce9fe3516e6f6a0ff04b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
pKID 116 - 149 2LXT C 116 - 149 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.