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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LYAM2_HUMAN (P16581)

Summary

This is the summary of UniProt entry LYAM2_HUMAN (P16581).

Description: E-selectin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 610 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 21
Pfam Lectin_C 29 140
disorder n/a 94 99
disorder n/a 101 102
Pfam EGF 143 173
Pfam Sushi 180 237
Pfam Sushi 242 299
Pfam Sushi 304 362
Pfam Sushi 367 425
Pfam Sushi 430 488
Pfam Sushi 493 547
transmembrane n/a 555 578
low_complexity n/a 556 571

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P16581. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI
50
51
QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG
100
101
EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG
150
151
HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF
200
201
SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN
250
251
GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK
300
301
AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT
350
351
TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ
400
401
GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE
450
451
FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG
500
501
KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP
550
551
TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD
600
601
GSYQKPSYIL                                            
610
 

Show the unformatted sequence.

Checksums:
CRC64:7D43E3C0D1229229
MD5:b7139cf745165201b27757c028ce28cb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EGF 143 - 173 1ESL A 122 - 152 Jmol OpenAstexViewer
1G1T A 122 - 152 Jmol OpenAstexViewer
4C16 A 122 - 152 Jmol OpenAstexViewer
B 122 - 152 Jmol OpenAstexViewer
4CSY A 122 - 152 Jmol OpenAstexViewer
B 122 - 152 Jmol OpenAstexViewer
Lectin_C 29 - 140 1ESL A 8 - 119 Jmol OpenAstexViewer
1G1T A 8 - 119 Jmol OpenAstexViewer
4C16 A 8 - 119 Jmol OpenAstexViewer
B 8 - 119 Jmol OpenAstexViewer
4CSY A 8 - 119 Jmol OpenAstexViewer
B 8 - 119 Jmol OpenAstexViewer
Sushi 180 - 237 4C16 A 159 - 216 Jmol OpenAstexViewer
B 159 - 216 Jmol OpenAstexViewer
4CSY A 159 - 216 Jmol OpenAstexViewer
B 159 - 216 Jmol OpenAstexViewer
242 - 299 4C16 A 221 - 278 Jmol OpenAstexViewer
B 221 - 278 Jmol OpenAstexViewer
4CSY A 221 - 278 Jmol OpenAstexViewer
B 221 - 278 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.