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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ZNF25_HUMAN (P17030)

Summary

This is the summary of UniProt entry ZNF25_HUMAN (P17030).

Description: Zinc finger protein 25
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 456 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam KRAB 7 48
disorder n/a 96 108
Pfam zf-C2H2 118 140
Pfam zf-C2H2 146 168
Pfam zf-C2H2 174 196
Pfam zf-C2H2 202 224
Pfam zf-C2H2 230 252
Pfam zf-C2H2 258 280
Pfam zf-C2H2 286 308
Pfam zf-C2H2 314 336
Pfam zf-C2H2 342 364
Pfam zf-C2H2 370 392
Pfam zf-C2H2 398 420
Pfam zf-C2H2 426 448
disorder n/a 442 456

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P17030. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH
50
51
VNKPNAVFKL KQGKEPWILE VEFPHRGFPE DLWSIHDLEA RYQESQAGNS
100
101
RNGELTKHQK THTTEKACEC KECGKFFCQK SALIVHQHTH SKGKSYDCDK
150
151
CGKSFSKNED LIRHQKIHTR DKTYECKECK KIFYHLSSLS RHLRTHAGEK
200
201
PYECNQCEKS FYQKPHLTEH QKTHTGEKPF ECTECGKFFY VKAYLMVHQK
250
251
THTGEKPYEC KECGKAFSQK SHLTVHQRMH TGEKPYKCKE CGKFFSRNSH
300
301
LKTHQRSHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT
350
351
FYYKSDLTKH QRKHTGEKPY ECTECGKSFA VNSVLRLHQR THTGEKPYAC
400
401
KECGKSFSQK SHFIIHQRKH TGEKPYECQE CGETFIQKSQ LTAHQKTHTK
450
451
KRNAEK                                                
456
 

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Checksums:
CRC64:9B65561962CBD85D
MD5:f125fa84f77cd7b290868ab0c81ea98b

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;