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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AATC_HUMAN (P17174)

Summary

This is the summary of UniProt entry AATC_HUMAN (P17174).

Description: Aspartate aminotransferase, cytoplasmic EC=2.6.1.1 EC=2.6.1.3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 413 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Aminotran_1_2 31 405
disorder n/a 36 37
disorder n/a 100 101
disorder n/a 134 135

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P17174. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA YRTDDCHPWV
50
51
LPVVKKVEQK IANDNSLNHE YLPILGLAEF RSCASRLALG DDSPALKEKR
100
101
VGGVQSLGGT GALRIGADFL ARWYNGTNNK NTPVYVSSPT WENHNAVFSA
150
151
AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN APEFSIVVLH ACAHNPTGID
200
201
PTPEQWKQIA SVMKHRFLFP FFDSAYQGFA SGNLERDAWA IRYFVSEGFE
250
251
FFCAQSFSKN FGLYNERVGN LTVVGKEPES ILQVLSQMEK IVRITWSNPP
300
301
AQGARIVAST LSNPELFEEW TGNVKTMADR ILTMRSELRA RLEALKTPGT
350
351
WNHITDQIGM FSFTGLNPKQ VEYLVNEKHI YLLPSGRINV SGLTTKNLDY
400
401
VATSIHEAVT KIQ                                        
413
 

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Checksums:
CRC64:69FE68BF0C045219
MD5:67f099236b8364eb70e266b2a3b16abc

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Aminotran_1_2 31 - 399 6DNA F 31 - 399 Show 3D Structure View in InterPro
31 - 403 6DNA C 31 - 403 Show 3D Structure View in InterPro
31 - 405 3II0 A 31 - 405 Show 3D Structure View in InterPro
B 31 - 405 Show 3D Structure View in InterPro
C 31 - 405 Show 3D Structure View in InterPro
D 31 - 405 Show 3D Structure View in InterPro
3WZF A 30 - 404 Show 3D Structure View in InterPro
6DNA A 31 - 405 Show 3D Structure View in InterPro
B 31 - 405 Show 3D Structure View in InterPro
D 31 - 405 Show 3D Structure View in InterPro
E 31 - 405 Show 3D Structure View in InterPro
6DNB A 31 - 405 Show 3D Structure View in InterPro
6DND A 31 - 405 Show 3D Structure View in InterPro
B 31 - 405 Show 3D Structure View in InterPro
6LIG A 31 - 405 Show 3D Structure View in InterPro
B 31 - 405 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;