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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: AK1C4_HUMAN (P17516)

Summary

This is the summary of UniProt entry AK1C4_HUMAN (P17516).

Description: Aldo-keto reductase family 1 member C4 EC=1.1.1.- EC=1.1.1.357 EC=1.1.1.225
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 323 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Aldo_ket_red 18 301

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P17516. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID
50
51
SAYLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE
100
101
SSLKKLQLDY VDLYLLHFPM ALKPGETPLP KDENGKVIFD TVDLSATWEV
150
151
MEKCKDAGLA KSIGVSNFNC RQLEMILNKP GLKYKPVCNQ VECHPYLNQS
200
201
KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV LCALAKKHKQ
250
251
TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN
300
301
RNYRYVVMDF LMDHPDYPFS DEY                             
323
 

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Checksums:
CRC64:E728CE4B420E8C58
MD5:05eee1cf1645b907701d65854579d36c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Aldo_ket_red 18 - 301 2FVL A 18 - 301 Jmol OpenAstexViewer
B 18 - 301 Jmol OpenAstexViewer
C 18 - 301 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.