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43  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KAPCA_HUMAN (P17612)

Summary

This is the summary of UniProt entry KAPCA_HUMAN (P17612).

Description: cAMP-dependent protein kinase catalytic subunit alpha EC=2.7.11.11
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 351 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 7
Pfam Pkinase 44 298

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P17612. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WESPAQNTAH LDQFERIKTL
50
51
GTGSFGRVML VKHKETGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN
100
101
FPFLVKLEFS FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ
150
151
IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY IQVTDFGFAK RVKGRTWTLC
200
201
GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK
250
251
IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT
300
301
TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFSE
350
351
F                                                     
351
 

Show the unformatted sequence.

Checksums:
CRC64:BF6D3ECD2614E5AB
MD5:f9f01faa42b67ad656136609dacd4e9a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 44 - 298 2GU8 A 43 - 297 Show 3D Structure View in InterPro
3AGL A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
3AGM A 43 - 297 Show 3D Structure View in InterPro
3AMA A 43 - 297 Show 3D Structure View in InterPro
3AMB A 43 - 297 Show 3D Structure View in InterPro
3L9L A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
3L9M A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
3L9N A 43 - 297 Show 3D Structure View in InterPro
3MVJ A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
E 43 - 297 Show 3D Structure View in InterPro
3NX8 A 43 - 297 Show 3D Structure View in InterPro
3OOG A 43 - 297 Show 3D Structure View in InterPro
3OVV A 43 - 297 Show 3D Structure View in InterPro
3OWP A 43 - 297 Show 3D Structure View in InterPro
3OXT A 43 - 297 Show 3D Structure View in InterPro
3P0M A 43 - 297 Show 3D Structure View in InterPro
3POO A 43 - 297 Show 3D Structure View in InterPro
3VQH A 43 - 297 Show 3D Structure View in InterPro
4AE6 A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
4AE9 A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
4UJ1 A 43 - 297 Show 3D Structure View in InterPro
4UJ2 A 43 - 297 Show 3D Structure View in InterPro
4UJ9 A 43 - 297 Show 3D Structure View in InterPro
4UJA A 43 - 297 Show 3D Structure View in InterPro
4UJB A 43 - 297 Show 3D Structure View in InterPro
4WB5 A 43 - 297 Show 3D Structure View in InterPro
4WB6 A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
4WB7 A 98 - 352 Show 3D Structure View in InterPro
B 98 - 352 Show 3D Structure View in InterPro
4WB8 A 43 - 297 Show 3D Structure View in InterPro
5BX6 A 43 - 297 Show 3D Structure View in InterPro
5BX7 A 43 - 297 Show 3D Structure View in InterPro
5IZF A 43 - 297 Show 3D Structure View in InterPro
5IZJ A 43 - 297 Show 3D Structure View in InterPro
B 43 - 297 Show 3D Structure View in InterPro
5J5X A 43 - 297 Show 3D Structure View in InterPro
5N23 A 43 - 297 Show 3D Structure View in InterPro
5UZK A 43 - 297 Show 3D Structure View in InterPro
6BYR A 98 - 352 Show 3D Structure View in InterPro
C 98 - 352 Show 3D Structure View in InterPro
6BYS A 43 - 297 Show 3D Structure View in InterPro
C 43 - 297 Show 3D Structure View in InterPro
E 43 - 297 Show 3D Structure View in InterPro
G 43 - 297 Show 3D Structure View in InterPro
6C0U A 43 - 297 Show 3D Structure View in InterPro
6FRX A 43 - 297 Show 3D Structure View in InterPro
6NO7 A 43 - 297 Show 3D Structure View in InterPro
C 43 - 297 Show 3D Structure View in InterPro
E 43 - 297 Show 3D Structure View in InterPro
G 43 - 297 Show 3D Structure View in InterPro
6QJ7 A 43 - 297 Show 3D Structure View in InterPro
6WJF A 98 - 352 Show 3D Structure View in InterPro
B 98 - 352 Show 3D Structure View in InterPro
6WJG A 98 - 352 Show 3D Structure View in InterPro
B 98 - 352 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;