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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KCNA6_HUMAN (P17658)

Summary

This is the summary of UniProt entry KCNA6_HUMAN (P17658).

Description: Potassium voltage-gated channel subfamily A member 6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 529 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 7 32
low_complexity n/a 32 40
Pfam BTB_2 43 134
disorder n/a 142 149
Pfam Ion_trans 173 469
transmembrane n/a 176 196
low_complexity n/a 178 190
low_complexity n/a 200 221
disorder n/a 211 239
low_complexity n/a 223 230
low_complexity n/a 244 257
disorder n/a 245 246
transmembrane n/a 263 283
transmembrane n/a 295 315
disorder n/a 320 328
low_complexity n/a 321 334
transmembrane n/a 335 355
low_complexity n/a 340 353
transmembrane n/a 376 397
low_complexity n/a 376 390
transmembrane n/a 437 458
disorder n/a 475 484
disorder n/a 488 489
disorder n/a 491 517

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P17658. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL
50
51
RFETQLRTLS LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY
100
101
QSGGRLRRPV NVPLDIFLEE IRFYQLGDEA LAAFREDEGC LPEGGEDEKP
150
151
LPSQPFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI FCLETLPQFR
200
201
VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP GEMGTGGSSS
250
251
LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID
300
301
LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF
350
351
RIFKLSRHSK GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD
400
401
DDDSLFPSIP DAFWWAVVTM TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI
450
451
ALPVPVIVSN FNYFYHRETE QEEQGQYTHV TCGQPAPDLR ATDNGLGKPD
500
501
FPEANRERRP SYLPTPHRAY AEKRMLTEV                       
529
 

Show the unformatted sequence.

Checksums:
CRC64:CFF0710A1F9CD69F
MD5:2bb216a4a4c39738254dbde08bc4b2b0

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;