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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: IBP2_HUMAN (P18065)

Summary

This is the summary of UniProt entry IBP2_HUMAN (P18065).

Description: Insulin-like growth factor-binding protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 325 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 36
low_complexity n/a 7 33
Pfam IGFBP 42 111
low_complexity n/a 50 70
disorder n/a 123 125
disorder n/a 134 179
disorder n/a 181 246
Pfam Thyroglobulin_1 227 306
disorder n/a 248 249
disorder n/a 252 254
disorder n/a 296 297
disorder n/a 305 307
disorder n/a 311 312
disorder n/a 317 325

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P18065. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL
50
51
AACGPPPVAP PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV
100
101
YTPRCGQGLR CYPHPGSELP LQALVMGEGT CEKRRDAEYG ASPEQVADNG
150
151
DDHSEGGLVE NHVDSTMNML GGGGSAGRKP LKSGMKELAV FREKVTEQHR
200
201
QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST MRLPDERGPL
250
251
EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI
300
301
RGDPECHLFY NEQQEARGVH TQRMQ                           
325
 

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Checksums:
CRC64:9E1436DBCCC6EA2A
MD5:a8a21495b8bbdecf69d901d4d22f73d6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Thyroglobulin_1 227 - 306 2H7T A 191 - 270 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.