Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DNLI1_HUMAN (P18858)

Summary

This is the summary of UniProt entry DNLI1_HUMAN (P18858).

Description: DNA ligase 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 919 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 278
low_complexity n/a 11 24
coiled_coil n/a 134 158
low_complexity n/a 141 168
low_complexity n/a 181 192
low_complexity n/a 209 217
low_complexity n/a 237 260
Pfam DNA_ligase_A_N 288 464
low_complexity n/a 344 355
disorder n/a 386 387
disorder n/a 390 395
low_complexity n/a 444 454
disorder n/a 474 483
disorder n/a 487 488
Pfam DNA_ligase_A_M 542 746
Pfam DNA_ligase_A_C 771 882
disorder n/a 889 891
disorder n/a 902 919

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P18858. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD
50
51
SPVKRPGRKA ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE
100
101
NNASLSDTSP MDSSPSGIPK RRTARKQLPK RTIQEVLEEQ SEDEDREAKR
150
151
KKEEEEEETP KESLTEAEVA TEKEGEDGDQ PTTPPKPLKT SKAETPTESV
200
201
SEPEVATKQE LQEEEEQTKP PRRAPKTLSS FFTPRKPAVK KEVKEEEPGA
250
251
PGKEGAAEGP LDPSGYNPAK NNYHPVEDAC WKPGQKVPYL AVARTFEKIE
300
301
EVSARLRMVE TLSNLLRSVV ALSPPDLLPV LYLSLNHLGP PQQGLELGVG
350
351
DGVLLKAVAQ ATGRQLESVR AEAAEKGDVG LVAENSRSTQ RLMLPPPPLT
400
401
ASGVFSKFRD IARLTGSAST AKKIDIIKGL FVACRHSEAR FIARSLSGRL
450
451
RLGLAEQSVL AALSQAVSLT PPGQEFPPAM VDAGKGKTAE ARKTWLEEQG
500
501
MILKQTFCEV PDLDRIIPVL LEHGLERLPE HCKLSPGIPL KPMLAHPTRG
550
551
ISEVLKRFEE AAFTCEYKYD GQRAQIHALE GGEVKIFSRN QEDNTGKYPD
600
601
IISRIPKIKL PSVTSFILDT EAVAWDREKK QIQPFQVLTT RKRKEVDASE
650
651
IQVQVCLYAF DLIYLNGESL VREPLSRRRQ LLRENFVETE GEFVFATSLD
700
701
TKDIEQIAEF LEQSVKDSCE GLMVKTLDVD ATYEIAKRSH NWLKLKKDYL
750
751
DGVGDTLDLV VIGAYLGRGK RAGRYGGFLL ASYDEDSEEL QAICKLGTGF
800
801
SDEELEEHHQ SLKALVLPSP RPYVRIDGAV IPDHWLDPSA VWEVKCADLS
850
851
LSPIYPAARG LVDSDKGISL RFPRFIRVRE DKQPEQATTS AQVACLYRKQ
900
901
SQIQNQQGED SGSDPEDTY                                  
919
 

Show the unformatted sequence.

Checksums:
CRC64:B2854DAE38A8D4AD
MD5:37e91690f5e0f24a31d5a90842f11c9b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_ligase_A_C 771 - 882 1X9N A 771 - 882 Show 3D Structure View in InterPro
6P09 A 771 - 882 Show 3D Structure View in InterPro
6P0A A 771 - 882 Show 3D Structure View in InterPro
6P0B A 771 - 882 Show 3D Structure View in InterPro
6P0C A 771 - 882 Show 3D Structure View in InterPro
6P0D A 771 - 882 Show 3D Structure View in InterPro
6P0E A 771 - 882 Show 3D Structure View in InterPro
6Q1V A 771 - 882 Show 3D Structure View in InterPro
7KR3 A 771 - 882 Show 3D Structure View in InterPro
7KR4 A 771 - 882 Show 3D Structure View in InterPro
7L34 A 771 - 882 Show 3D Structure View in InterPro
7L35 A 771 - 882 Show 3D Structure View in InterPro
DNA_ligase_A_M 542 - 746 1X9N A 542 - 746 Show 3D Structure View in InterPro
6P09 A 542 - 746 Show 3D Structure View in InterPro
6P0A A 542 - 746 Show 3D Structure View in InterPro
6P0B A 542 - 746 Show 3D Structure View in InterPro
6P0C A 542 - 746 Show 3D Structure View in InterPro
6P0D A 542 - 746 Show 3D Structure View in InterPro
6P0E A 542 - 746 Show 3D Structure View in InterPro
6Q1V A 542 - 746 Show 3D Structure View in InterPro
7KR3 A 542 - 746 Show 3D Structure View in InterPro
7KR4 A 542 - 746 Show 3D Structure View in InterPro
7L34 A 542 - 746 Show 3D Structure View in InterPro
7L35 A 542 - 746 Show 3D Structure View in InterPro
DNA_ligase_A_N 288 - 464 1X9N A 288 - 464 Show 3D Structure View in InterPro
6P09 A 288 - 464 Show 3D Structure View in InterPro
6P0A A 288 - 464 Show 3D Structure View in InterPro
6P0B A 288 - 464 Show 3D Structure View in InterPro
6P0C A 288 - 464 Show 3D Structure View in InterPro
6P0D A 288 - 464 Show 3D Structure View in InterPro
6P0E A 288 - 464 Show 3D Structure View in InterPro
6Q1V A 288 - 464 Show 3D Structure View in InterPro
7KR3 A 288 - 464 Show 3D Structure View in InterPro
7KR4 A 288 - 464 Show 3D Structure View in InterPro
7L34 A 288 - 464 Show 3D Structure View in InterPro
7L35 A 288 - 464 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;