Summary
This is the summary of UniProt entry ANPRA_RAT (P18910).
| Description: | Atrial natriuretic peptide receptor 1 EC=4.6.1.2 |
| Source organism: |
Rattus norvegicus (Rat)
(NCBI taxonomy ID
10116)
|
| Length: | 1057 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 28 |
| low_complexity | n/a | 4 | 23 |
| Pfam | ANF_receptor | 50 | 413 |
| disorder | n/a | 283 | 284 |
| disorder | n/a | 287 | 290 |
| disorder | n/a | 293 | 295 |
| disorder | n/a | 367 | 369 |
| disorder | n/a | 371 | 372 |
| disorder | n/a | 452 | 455 |
| transmembrane | n/a | 470 | 490 |
| low_complexity | n/a | 475 | 488 |
| Pfam | PK_Tyr_Ser-Thr | 539 | 797 |
| disorder | n/a | 751 | 756 |
| disorder | n/a | 758 | 765 |
| coiled_coil | n/a | 802 | 840 |
| Pfam | Guanylate_cyc | 863 | 1049 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P18910. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MPGSRRVRPR LRALLLLPPL LLLRGGHASD LTVAVVLPLT NTSYPWSWAR
50 51
VGPAVELALA RVKARPDLLP GWTVRMVLGS SENAAGVCSD TAAPLAAVDL
100 101
KWEHSPAVFL GPGCVYSAAP VGRFTAHWRV PLLTAGAPAL GIGVKDEYAL
150 151
TTRTGPSHVK LGDFVTALHR RLGWEHQALV LYADRLGDDR PCFFIVEGLY
200 201
MRVRERLNIT VNHQEFVEGD PDHYPKLLRA VRRKGRVIYI CSSPDAFRNL
250 251
MLLALNAGLT GEDYVFFHLD VFGQSLKSAQ GLVPQKPWER GDGQDRSARQ
300 301
AFQAAKIITY KEPDNPEYLE FLKQLKLLAD KKFNFTVEDG LKNIIPASFH
350 351
DGLLLYVQAV TETLAQGGTV TDGENITQRM WNRSFQGVTG YLKIDRNGDR
400 401
DTDFSLWDMD PETGAFRVVL NYNGTSQELM AVSEHKLYWP LGYPPPDVPK
450 451
CGFDNEDPAC NQDHFSTLEV LALVGSLSLI SFLIVSFFIY RKMQLEKELV
500 501
SELWRVRWED LQPSSLERHL RSAGSRLTLS GRGSNYGSLL TTEGQFQVFA
550 551
KTAYYKGNLV AVKRVNRKRI ELTRKVLFEL KHMRDVQNEH LTRFVGACTD
600 601
PPNICILTEY CPRGSLQDIL ENESITLDWM FRYSLTNDIV KGMLFLHNGA
650 651
ICSHGNLKSS NCVVDGRFVL KITDYGLESF RDPEPEQGHT LFAKKLWTAP
700 701
ELLRMASPPA RGSQAGDVYS FGIILQEIAL RSGVFYVEGL DLSPKEIIER
750 751
VTRGEQPPFR PSMDLQSHLE ELGQLMQRCW AEDPQERPPF QQIRLALRKF
800 801
NKENSSNILD NLLSRMEQYA NNLEELVEER TQAYLEEKRK AEALLYQILP
850 851
HSVAEQLKRG ETVQAEAFDS VTIYFSDIVG FTALSAESTP MQVVTLLNDL
900 901
YTCFDAVIDN FDVYKVETIG DAYMVVSGLP VRNGQLHARE VARMALALLD
950 951
AVRSFRIRHR PQEQLRLRIG IHTGPVCAGV VGLKMPRYCL FGDTVNTASR
1000 1001
MESNGEALKI HLSSETKAVL EEFDGFELEL RGDVEMKGKG KVRTYWLLGE
1050 1051
RGCSTRG
1057
Show the unformatted sequence. |
| Checksums: |
CRC64:9EA9AE685AC05816
MD5:17a7199113ec2e9fb3bd029e253cd4fb
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| ANF_receptor | 50 - 413 | 1DP4 | A | 22 - 385 | Jmol OpenAstexViewer |
| C | 22 - 385 | Jmol OpenAstexViewer | |||
| 1T34 | A | 22 - 385 | Jmol OpenAstexViewer | ||
| B | 22 - 385 | Jmol OpenAstexViewer | |||
| 3A3K | A | 22 - 385 | Jmol OpenAstexViewer | ||
| B | 22 - 385 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
