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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CADH2_HUMAN (P19022)

Summary

This is the summary of UniProt entry CADH2_HUMAN (P19022).

Description: Cadherin-2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 906 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 25
low_complexity n/a 5 21
Pfam Cadherin_pro 31 121
low_complexity n/a 129 140
Pfam Cadherin 164 258
disorder n/a 166 168
disorder n/a 174 175
disorder n/a 177 181
disorder n/a 193 198
disorder n/a 206 209
low_complexity n/a 247 263
disorder n/a 268 274
Pfam Cadherin 272 373
disorder n/a 284 288
disorder n/a 315 323
disorder n/a 370 375
disorder n/a 381 387
Pfam Cadherin 387 489
disorder n/a 402 404
disorder n/a 414 420
disorder n/a 429 438
disorder n/a 444 446
disorder n/a 470 476
disorder n/a 482 485
Pfam Cadherin 502 596
disorder n/a 502 503
disorder n/a 514 518
disorder n/a 520 522
disorder n/a 529 532
disorder n/a 557 558
disorder n/a 605 614
Pfam Cadherin 608 701
disorder n/a 616 618
low_complexity n/a 715 740
transmembrane n/a 724 746
disorder n/a 756 759
disorder n/a 770 775
low_complexity n/a 773 786
disorder n/a 777 778
disorder n/a 781 794
disorder n/a 798 804
disorder n/a 807 808
disorder n/a 812 813
disorder n/a 815 828
disorder n/a 833 858
Pfam CADH_Y-type_LIR 843 902
low_complexity n/a 862 880
disorder n/a 866 885
disorder n/a 905 906

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P19022. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH
50
51
EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA
100
101
KFLIYAQDKE TQEKWQVAVK LSLKPTLTEE SVKESAEVEE IVFPRQFSKH
150
151
SGHLQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP
200
201
GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP
250
251
IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL
300
301
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ
350
351
ATDMEGNPTY GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV
400
401
ANLTVTDKDQ PHTPAWNAVY RISGGDPTGR FAIQTDPNSN DGLVTVVKPI
450
451
DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN
500
501
PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN
550
551
GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND
600
601
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR
650
651
NWTITRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV
700
701
CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD
750
751
KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA
800
801
IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP
850
851
PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM
900
901
YGGGDD                                                
906
 

Show the unformatted sequence.

Checksums:
CRC64:7267E2A00489DF94
MD5:98fbf27bc02855da496bffe6cb674d08

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;