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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: E2AK2_HUMAN (P19525)

Summary

This is the summary of UniProt entry E2AK2_HUMAN (P19525).

Description: Interferon-induced, double-stranded RNA-activated protein kinase EC=2.7.11.1 EC=2.7.10.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 551 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam dsrm 10 75
disorder n/a 25 31
disorder n/a 54 60
coiled_coil n/a 58 80
low_complexity n/a 59 70
Pfam dsrm 101 165
disorder n/a 146 148
low_complexity n/a 149 163
disorder n/a 205 215
low_complexity n/a 215 234
disorder n/a 226 228
disorder n/a 239 241
disorder n/a 243 245
Pfam Pkinase 267 537
coiled_coil n/a 295 315
disorder n/a 338 350
disorder n/a 447 448
disorder n/a 450 453
low_complexity n/a 470 481
disorder n/a 518 520
disorder n/a 549 551

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P19525. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGDLSAGFF MEELNTYRQK QGVVLKYQEL PNSGPPHDRR FTFQVIIDGR
50
51
EFPEGEGRSK KEAKNAAAKL AVEILNKEKK AVSPLLLTTT NSSEGLSMGN
100
101
YIGLINRIAQ KKRLTVNYEQ CASGVHGPEG FHYKCKMGQK EYSIGTGSTK
150
151
QEAKQLAAKL AYLQILSEET SVKSDYLSSG SFATTCESQS NSLVTSTLAS
200
201
ESSSEGDFSA DTSEINSNSD SLNSSSLLMN GLRNNQRKAK RSLAPRFDLP
250
251
DMKETKYTVD KRFGMDFKEI ELIGSGGFGQ VFKAKHRIDG KTYVIKRVKY
300
301
NNEKAEREVK ALAKLDHVNI VHYNGCWDGF DYDPETSDDS LESSDYDPEN
350
351
SKNSSRSKTK CLFIQMEFCD KGTLEQWIEK RRGEKLDKVL ALELFEQITK
400
401
GVDYIHSKKL IHRDLKPSNI FLVDTKQVKI GDFGLVTSLK NDGKRTRSKG
450
451
TLRYMSPEQI SSQDYGKEVD LYALGLILAE LLHVCDTAFE TSKFFTDLRD
500
501
GIISDIFDKK EKTLLQKLLS KKPEDRPNTS EILRTLTVWK KSPEKNERHT
550
551
C                                                     
551
 

Show the unformatted sequence.

Checksums:
CRC64:815AD83ACAB45DA3
MD5:35647e82876c1dd6f63ecfaec98c20f4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
dsrm 10 - 75 1QU6 A 15 - 80 Jmol OpenAstexViewer
101 - 165 1QU6 A 106 - 170 Jmol OpenAstexViewer
Pkinase 267 - 537 2A19 B 267 - 537 Jmol OpenAstexViewer
C 267 - 537 Jmol OpenAstexViewer
2A1A B 267 - 537 Jmol OpenAstexViewer
3UIU A 267 - 537 Jmol OpenAstexViewer
B 267 - 537 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.