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100  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RXRA_HUMAN (P19793)

Summary

This is the summary of UniProt entry RXRA_HUMAN (P19793).

Description: Retinoic acid receptor RXR-alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 462 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 6 7
disorder n/a 9 56
Pfam Nuc_recep-AF1 17 127
disorder n/a 62 67
disorder n/a 69 107
disorder n/a 109 110
disorder n/a 112 118
Pfam zf-C4 133 202
low_complexity n/a 181 195
disorder n/a 205 228
disorder n/a 250 257
Pfam Hormone_recep 257 442
disorder n/a 260 265

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P19793. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP
50
51
ISTLSSPING MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP
100
101
VSSSEDIKPP LGLNGVLKVP AHPSGNMASF TKHICAICGD RSSGKHYGVY
150
151
SCEGCKGFFK RTVRKDLTYT CRDNKDCLID KRQRNRCQYC RYQKCLAMGM
200
201
KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL AVEPKTETYV
250
251
EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL
300
301
LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL
350
351
TELVSKMRDM QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL
400
401
EAYCKHKYPE QPGRFAKLLL RLPALRSIGL KCLEHLFFFK LIGDTPIDTF
450
451
LMEMLEAPHQ MT                                         
462
 

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Checksums:
CRC64:7F952B580AD84C42
MD5:f62a998386a21b9265bbad8b8c9e1acc

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Hormone_recep 257 - 442 1FM6 A 257 - 442 Show 3D Structure View in InterPro
U 257 - 442 Show 3D Structure View in InterPro
1FM9 A 257 - 442 Show 3D Structure View in InterPro
1G1U A 257 - 442 Show 3D Structure View in InterPro
B 257 - 442 Show 3D Structure View in InterPro
C 257 - 442 Show 3D Structure View in InterPro
D 257 - 442 Show 3D Structure View in InterPro
1G5Y A 257 - 442 Show 3D Structure View in InterPro
B 257 - 442 Show 3D Structure View in InterPro
C 257 - 442 Show 3D Structure View in InterPro
D 257 - 442 Show 3D Structure View in InterPro
1K74 A 257 - 442 Show 3D Structure View in InterPro
1XLS A 257 - 442 Show 3D Structure View in InterPro
B 257 - 442 Show 3D Structure View in InterPro
C 257 - 442 Show 3D Structure View in InterPro
D 257 - 442 Show 3D Structure View in InterPro
1XV9 A 257 - 442 Show 3D Structure View in InterPro
C 257 - 442 Show 3D Structure View in InterPro
1XVP A 257 - 442 Show 3D Structure View in InterPro
C 257 - 442 Show 3D Structure View in InterPro
4J5X D 257 - 442 Show 3D Structure View in InterPro
4NQA A 257 - 442 Show 3D Structure View in InterPro
6HN6 A 257 - 442 Show 3D Structure View in InterPro
259 - 442 5MK4 A 259 - 442 Show 3D Structure View in InterPro
C 259 - 442 Show 3D Structure View in InterPro
261 - 442 3UVV B 261 - 442 Show 3D Structure View in InterPro
4J5W C 261 - 442 Show 3D Structure View in InterPro
D 261 - 442 Show 3D Structure View in InterPro
4J5X C 261 - 442 Show 3D Structure View in InterPro
4N5G B 261 - 442 Show 3D Structure View in InterPro
C 261 - 442 Show 3D Structure View in InterPro
4N8R B 261 - 442 Show 3D Structure View in InterPro
5MJ5 A 261 - 442 Show 3D Structure View in InterPro
5TBP B 261 - 442 Show 3D Structure View in InterPro
C 261 - 442 Show 3D Structure View in InterPro
5ZQU B 261 - 442 Show 3D Structure View in InterPro
6JNR B 261 - 442 Show 3D Structure View in InterPro
262 - 442 1MZN A 262 - 442 Show 3D Structure View in InterPro
E 2262 - 2442 Show 3D Structure View in InterPro
2ZXZ A 262 - 442 Show 3D Structure View in InterPro
2ZY0 A 262 - 442 Show 3D Structure View in InterPro
C 262 - 442 Show 3D Structure View in InterPro
3H0A A 262 - 442 Show 3D Structure View in InterPro
3OAP A 262 - 442 Show 3D Structure View in InterPro
3OZJ A 262 - 442 Show 3D Structure View in InterPro
C 262 - 442 Show 3D Structure View in InterPro
3R2A B 262 - 442 Show 3D Structure View in InterPro
3R5M A 262 - 442 Show 3D Structure View in InterPro
C 262 - 442 Show 3D Structure View in InterPro
4K4J A 262 - 442 Show 3D Structure View in InterPro
4K6I A 262 - 442 Show 3D Structure View in InterPro
4M8E A 262 - 442 Show 3D Structure View in InterPro
4M8H A 262 - 442 Show 3D Structure View in InterPro
4N8R C 262 - 442 Show 3D Structure View in InterPro
4NQA H 262 - 442 Show 3D Structure View in InterPro
4OC7 A 262 - 442 Show 3D Structure View in InterPro
4POH A 262 - 442 Show 3D Structure View in InterPro
4POJ A 262 - 442 Show 3D Structure View in InterPro
4PP3 A 262 - 442 Show 3D Structure View in InterPro
4PP5 A 262 - 442 Show 3D Structure View in InterPro
4RFW A 262 - 442 Show 3D Structure View in InterPro
4RMC A 262 - 442 Show 3D Structure View in InterPro
4RMD A 262 - 442 Show 3D Structure View in InterPro
4RME A 262 - 442 Show 3D Structure View in InterPro
4ZSH A 262 - 442 Show 3D Structure View in InterPro
5JI0 A 262 - 442 Show 3D Structure View in InterPro
5MMW A 262 - 442 Show 3D Structure View in InterPro
5Z12 B 262 - 442 Show 3D Structure View in InterPro
5ZQU C 262 - 442 Show 3D Structure View in InterPro
6A5Z D 262 - 442 Show 3D Structure View in InterPro
6JNO D 262 - 442 Show 3D Structure View in InterPro
6JNR A 262 - 442 Show 3D Structure View in InterPro
6LB5 C 262 - 442 Show 3D Structure View in InterPro
6SJM A 262 - 442 Show 3D Structure View in InterPro
7A77 A 262 - 442 Show 3D Structure View in InterPro
7B88 A 262 - 442 Show 3D Structure View in InterPro
7BK4 A 262 - 442 Show 3D Structure View in InterPro
263 - 433 3FAL A 263 - 433 Show 3D Structure View in InterPro
C 263 - 433 Show 3D Structure View in InterPro
263 - 434 3FC6 C 263 - 434 Show 3D Structure View in InterPro
263 - 441 3FC6 A 263 - 441 Show 3D Structure View in InterPro
263 - 442 1FBY A 263 - 442 Show 3D Structure View in InterPro
B 1263 - 1442 Show 3D Structure View in InterPro
1MV9 A 263 - 442 Show 3D Structure View in InterPro
1MVC A 263 - 442 Show 3D Structure View in InterPro
1MZN C 1263 - 1442 Show 3D Structure View in InterPro
G 3263 - 3442 Show 3D Structure View in InterPro
1RDT A 263 - 442 Show 3D Structure View in InterPro
2ACL A 263 - 442 Show 3D Structure View in InterPro
C 263 - 442 Show 3D Structure View in InterPro
E 263 - 442 Show 3D Structure View in InterPro
G 263 - 442 Show 3D Structure View in InterPro
2P1T A 263 - 442 Show 3D Structure View in InterPro
2P1U A 263 - 442 Show 3D Structure View in InterPro
2P1V A 263 - 442 Show 3D Structure View in InterPro
3DZU A 263 - 442 Show 3D Structure View in InterPro
3E94 A 263 - 442 Show 3D Structure View in InterPro
3FUG A 263 - 442 Show 3D Structure View in InterPro
3KWY A 263 - 442 Show 3D Structure View in InterPro
3NSP A 263 - 442 Show 3D Structure View in InterPro
3NSQ A 263 - 442 Show 3D Structure View in InterPro
3PCU A 263 - 442 Show 3D Structure View in InterPro
3R29 A 263 - 442 Show 3D Structure View in InterPro
B 263 - 442 Show 3D Structure View in InterPro
3R2A A 263 - 442 Show 3D Structure View in InterPro
4N5G A 263 - 442 Show 3D Structure View in InterPro
D 263 - 442 Show 3D Structure View in InterPro
4N8R A 263 - 442 Show 3D Structure View in InterPro
D 263 - 442 Show 3D Structure View in InterPro
5EC9 A 263 - 442 Show 3D Structure View in InterPro
5LYQ A 263 - 442 Show 3D Structure View in InterPro
5MKJ A 263 - 442 Show 3D Structure View in InterPro
5MKU A 263 - 442 Show 3D Structure View in InterPro
5TBP A 263 - 442 Show 3D Structure View in InterPro
D 263 - 442 Show 3D Structure View in InterPro
5ZQU A 263 - 442 Show 3D Structure View in InterPro
6A5Y D 263 - 442 Show 3D Structure View in InterPro
6A5Z L 263 - 442 Show 3D Structure View in InterPro
6A60 D 263 - 442 Show 3D Structure View in InterPro
6L6K A 263 - 442 Show 3D Structure View in InterPro
6LB4 A 263 - 442 Show 3D Structure View in InterPro
6LB5 A 263 - 442 Show 3D Structure View in InterPro
6LB6 A 263 - 442 Show 3D Structure View in InterPro
6STI A 263 - 442 Show 3D Structure View in InterPro
7B9O A 263 - 442 Show 3D Structure View in InterPro
7BK4 C 263 - 442 Show 3D Structure View in InterPro
264 - 442 3DZY A 264 - 442 Show 3D Structure View in InterPro
3NSQ B 264 - 442 Show 3D Structure View in InterPro
3R2A D 264 - 442 Show 3D Structure View in InterPro
5UAN A 264 - 442 Show 3D Structure View in InterPro
5Z12 C 264 - 442 Show 3D Structure View in InterPro
5ZQU D 264 - 442 Show 3D Structure View in InterPro
6JNO A 264 - 442 Show 3D Structure View in InterPro
B 264 - 442 Show 3D Structure View in InterPro
C 264 - 442 Show 3D Structure View in InterPro
7CFO A 264 - 442 Show 3D Structure View in InterPro
B 264 - 442 Show 3D Structure View in InterPro
C 264 - 442 Show 3D Structure View in InterPro
265 - 442 3E00 A 265 - 442 Show 3D Structure View in InterPro
4ZO1 B 265 - 442 Show 3D Structure View in InterPro
268 - 442 3R2A C 268 - 442 Show 3D Structure View in InterPro
7CFO D 268 - 442 Show 3D Structure View in InterPro
270 - 442 3NSP B 270 - 442 Show 3D Structure View in InterPro
zf-C4 133 - 202 1BY4 A 1133 - 1202 Show 3D Structure View in InterPro
B 1233 - 1302 Show 3D Structure View in InterPro
C 2133 - 2202 Show 3D Structure View in InterPro
D 2233 - 2302 Show 3D Structure View in InterPro
1DSZ B 1233 - 1302 Show 3D Structure View in InterPro
1R0N A 99 - 168 Show 3D Structure View in InterPro
1RXR A 133 - 202 Show 3D Structure View in InterPro
3DZU A 133 - 202 Show 3D Structure View in InterPro
3DZY A 133 - 202 Show 3D Structure View in InterPro
3E00 A 133 - 202 Show 3D Structure View in InterPro
4CN2 C 133 - 202 Show 3D Structure View in InterPro
D 133 - 202 Show 3D Structure View in InterPro
4CN3 A 133 - 202 Show 3D Structure View in InterPro
B 133 - 202 Show 3D Structure View in InterPro
C 133 - 202 Show 3D Structure View in InterPro
D 133 - 202 Show 3D Structure View in InterPro
4CN5 A 133 - 202 Show 3D Structure View in InterPro
B 133 - 202 Show 3D Structure View in InterPro
4CN7 A 133 - 202 Show 3D Structure View in InterPro
B 133 - 202 Show 3D Structure View in InterPro
E 133 - 202 Show 3D Structure View in InterPro
F 133 - 202 Show 3D Structure View in InterPro
4NQA A 133 - 202 Show 3D Structure View in InterPro
H 133 - 202 Show 3D Structure View in InterPro
5UAN A 133 - 202 Show 3D Structure View in InterPro
6FBQ A 133 - 202 Show 3D Structure View in InterPro
B 133 - 202 Show 3D Structure View in InterPro
6FBR A 133 - 202 Show 3D Structure View in InterPro
B 133 - 202 Show 3D Structure View in InterPro
6XWG C 133 - 202 Show 3D Structure View in InterPro
6XWH C 133 - 202 Show 3D Structure View in InterPro
D 133 - 202 Show 3D Structure View in InterPro
134 - 202 1YNW B 234 - 302 Show 3D Structure View in InterPro
135 - 200 2NLL A 135 - 200 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;