Summary
This is the summary of UniProt entry NFKB1_HUMAN (P19838).
| Description: | Nuclear factor NF-kappa-B p105 subunit |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 968 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 3 |
| disorder | n/a | 8 | 9 |
| disorder | n/a | 12 | 13 |
| disorder | n/a | 42 | 43 |
| Pfam | RHD_DNA_bind | 44 | 242 |
| disorder | n/a | 68 | 75 |
| Pfam | RHD_dimer | 251 | 353 |
| disorder | n/a | 296 | 297 |
| disorder | n/a | 334 | 335 |
| disorder | n/a | 350 | 354 |
| disorder | n/a | 360 | 405 |
| low_complexity | n/a | 372 | 402 |
| disorder | n/a | 420 | 450 |
| disorder | n/a | 452 | 453 |
| disorder | n/a | 457 | 489 |
| Pfam | Ank | 583 | 613 |
| low_complexity | n/a | 633 | 643 |
| Pfam | Ank_2 | 679 | 749 |
| disorder | n/a | 761 | 762 |
| disorder | n/a | 764 | 773 |
| Pfam | Death | 816 | 892 |
| disorder | n/a | 859 | 861 |
| disorder | n/a | 897 | 913 |
| disorder | n/a | 915 | 921 |
| disorder | n/a | 949 | 968 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P19838. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAEDDPYLGR PEQMFHLDPS LTHTIFNPEV FQPQMALPTD GPYLQILEQP
50 51
KQRGFRFRYV CEGPSHGGLP GASSEKNKKS YPQVKICNYV GPAKVIVQLV
100 101
TNGKNIHLHA HSLVGKHCED GICTVTAGPK DMVVGFANLG ILHVTKKKVF
150 151
ETLEARMTEA CIRGYNPGLL VHPDLAYLQA EGGGDRQLGD REKELIRQAA
200 201
LQQTKEMDLS VVRLMFTAFL PDSTGSFTRR LEPVVSDAIY DSKAPNASNL
250 251
KIVRMDRTAG CVTGGEEIYL LCDKVQKDDI QIRFYEEEEN GGVWEGFGDF
300 301
SPTDVHRQFA IVFKTPKYKD INITKPASVF VQLRRKSDLE TSEPKPFLYY
350 351
PEIKDKEEVQ RKRQKLMPNF SDSFGGGSGA GAGGGGMFGS GGGGGGTGST
400 401
GPGYSFPHYG FPTYGGITFH PGTTKSNAGM KHGTMDTESK KDPEGCDKSD
450 451
DKNTVNLFGK VIETTEQDQE PSEATVGNGE VTLTYATGTK EESAGVQDNL
500 501
FLEKAMQLAK RHANALFDYA VTGDVKMLLA VQRHLTAVQD ENGDSVLHLA
550 551
IIHLHSQLVR DLLEVTSGLI SDDIINMRND LYQTPLHLAV ITKQEDVVED
600 601
LLRAGADLSL LDRLGNSVLH LAAKEGHDKV LSILLKHKKA ALLLDHPNGD
650 651
GLNAIHLAMM SNSLPCLLLL VAAGADVNAQ EQKSGRTALH LAVEHDNISL
700 701
AGCLLLEGDA HVDSTTYDGT TPLHIAAGRG STRLAALLKA AGADPLVENF
750 751
EPLYDLDDSW ENAGEDEGVV PGTTPLDMAT SWQVFDILNG KPYEPEFTSD
800 801
DLLAQGDMKQ LAEDVKLQLY KLLEIPDPDK NWATLAQKLG LGILNNAFRL
850 851
SPAPSKTLMD NYEVSGGTVR ELVEALRQMG YTEAIEVIQA ASSPVKTTSQ
900 901
AHSLPLSPAS TRQQIDELRD SDSVCDSGVE TSFRKLSFTE SLTSGASLLT
950 951
LNKMPHDYGQ EGPLEGKI
968
Show the unformatted sequence. |
| Checksums: |
CRC64:2A7C8FF86A10D1A8
MD5:6861899f94eecd13ca6e5d92b4634043
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Death | 816 - 892 | 2DBF | A | 17 - 93 | Jmol OpenAstexViewer |
| RHD_dimer | 251 - 352 | 1SVC | P | 252 - 353 | Jmol OpenAstexViewer |
| 2O61 | B | 249 - 350 | Jmol OpenAstexViewer | ||
| 3GUT | B | 549 - 650 | Jmol OpenAstexViewer | ||
| D | 549 - 650 | Jmol OpenAstexViewer | |||
| F | 549 - 650 | Jmol OpenAstexViewer | |||
| H | 549 - 650 | Jmol OpenAstexViewer | |||
| 251 - 353 | 1NFI | B | 252 - 354 | Jmol OpenAstexViewer | |
| D | 252 - 354 | Jmol OpenAstexViewer | |||
| RHD_DNA_bind | 44 - 242 | 1SVC | P | 45 - 243 | Jmol OpenAstexViewer |
| 2O61 | B | 42 - 240 | Jmol OpenAstexViewer | ||
| 3GUT | B | 342 - 540 | Jmol OpenAstexViewer | ||
| D | 342 - 540 | Jmol OpenAstexViewer | |||
| F | 342 - 540 | Jmol OpenAstexViewer | |||
| H | 342 - 540 | Jmol OpenAstexViewer | |||
| 55 - 67 | 1MDI | B | 1 - 13 | Jmol OpenAstexViewer | |
| 1MDJ | B | 1 - 13 | Jmol OpenAstexViewer | ||
| 1MDK | B | 1 - 13 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
