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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NFKB1_HUMAN (P19838)

Summary

This is the summary of UniProt entry NFKB1_HUMAN (P19838).

Description: Nuclear factor NF-kappa-B p105 subunit
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 968 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 3
disorder n/a 8 9
disorder n/a 12 13
disorder n/a 42 43
Pfam RHD_DNA_bind 44 242
disorder n/a 68 75
Pfam RHD_dimer 251 353
disorder n/a 296 297
disorder n/a 334 335
disorder n/a 350 354
disorder n/a 360 405
low_complexity n/a 373 403
disorder n/a 420 450
disorder n/a 452 453
disorder n/a 457 489
Pfam Ank 583 613
low_complexity n/a 634 644
Pfam Ank 718 750
disorder n/a 761 762
disorder n/a 764 773
Pfam Death 816 892
disorder n/a 859 861
disorder n/a 897 913
disorder n/a 915 921
disorder n/a 949 968

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P19838. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEDDPYLGR PEQMFHLDPS LTHTIFNPEV FQPQMALPTD GPYLQILEQP
50
51
KQRGFRFRYV CEGPSHGGLP GASSEKNKKS YPQVKICNYV GPAKVIVQLV
100
101
TNGKNIHLHA HSLVGKHCED GICTVTAGPK DMVVGFANLG ILHVTKKKVF
150
151
ETLEARMTEA CIRGYNPGLL VHPDLAYLQA EGGGDRQLGD REKELIRQAA
200
201
LQQTKEMDLS VVRLMFTAFL PDSTGSFTRR LEPVVSDAIY DSKAPNASNL
250
251
KIVRMDRTAG CVTGGEEIYL LCDKVQKDDI QIRFYEEEEN GGVWEGFGDF
300
301
SPTDVHRQFA IVFKTPKYKD INITKPASVF VQLRRKSDLE TSEPKPFLYY
350
351
PEIKDKEEVQ RKRQKLMPNF SDSFGGGSGA GAGGGGMFGS GGGGGGTGST
400
401
GPGYSFPHYG FPTYGGITFH PGTTKSNAGM KHGTMDTESK KDPEGCDKSD
450
451
DKNTVNLFGK VIETTEQDQE PSEATVGNGE VTLTYATGTK EESAGVQDNL
500
501
FLEKAMQLAK RHANALFDYA VTGDVKMLLA VQRHLTAVQD ENGDSVLHLA
550
551
IIHLHSQLVR DLLEVTSGLI SDDIINMRND LYQTPLHLAV ITKQEDVVED
600
601
LLRAGADLSL LDRLGNSVLH LAAKEGHDKV LSILLKHKKA ALLLDHPNGD
650
651
GLNAIHLAMM SNSLPCLLLL VAAGADVNAQ EQKSGRTALH LAVEHDNISL
700
701
AGCLLLEGDA HVDSTTYDGT TPLHIAAGRG STRLAALLKA AGADPLVENF
750
751
EPLYDLDDSW ENAGEDEGVV PGTTPLDMAT SWQVFDILNG KPYEPEFTSD
800
801
DLLAQGDMKQ LAEDVKLQLY KLLEIPDPDK NWATLAQKLG LGILNNAFRL
850
851
SPAPSKTLMD NYEVSGGTVR ELVEALRQMG YTEAIEVIQA ASSPVKTTSQ
900
901
AHSLPLSPAS TRQQIDELRD SDSVCDSGVE TSFRKLSFTE SLTSGASLLT
950
951
LNKMPHDYGQ EGPLEGKI                                   
968
 

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Checksums:
CRC64:2A7C8FF86A10D1A8
MD5:6861899f94eecd13ca6e5d92b4634043

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Death 816 - 892 2DBF A 17 - 93 NGL View in InterPro
RHD_dimer 251 - 352 1SVC P 252 - 353 NGL View in InterPro
2O61 B 249 - 350 NGL View in InterPro
3GUT B 549 - 650 NGL View in InterPro
D 549 - 650 NGL View in InterPro
F 549 - 650 NGL View in InterPro
H 549 - 650 NGL View in InterPro
251 - 353 1NFI B 252 - 354 NGL View in InterPro
D 252 - 354 NGL View in InterPro
RHD_DNA_bind 44 - 242 1SVC P 45 - 243 NGL View in InterPro
2O61 B 42 - 240 NGL View in InterPro
3GUT B 342 - 540 NGL View in InterPro
D 342 - 540 NGL View in InterPro
F 342 - 540 NGL View in InterPro
H 342 - 540 NGL View in InterPro
55 - 67 1MDI B 1 - 13 NGL View in InterPro
1MDJ B 1 - 13 NGL View in InterPro
1MDK B 1 - 13 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.