Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NCF2_HUMAN (P19878)

Summary

This is the summary of UniProt entry NCF2_HUMAN (P19878).

Description: Neutrophil cytosol factor 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 526 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam TPR_8 37 69
low_complexity n/a 132 147
low_complexity n/a 218 234
disorder n/a 219 237
Pfam SH3_1 246 291
disorder n/a 299 346
low_complexity n/a 303 315
Pfam PB1 351 429
disorder n/a 373 375
disorder n/a 386 408
disorder n/a 433 456
Pfam SH3_1 463 508
disorder n/a 463 464
disorder n/a 525 526

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P19878. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSLVEAISLW NEGVLAADKK DWKGALDAFS AVQDPHSRIC FNIGCMYTIL
50
51
KNMTEAEKAF TRSINRDKHL AVAYFQRGML YYQTEKYDLA IKDLKEALIQ
100
101
LRGNQLIDYK ILGLQFKLFA CEVLYNIAFM YAKKEEWKKA EEQLALATSM
150
151
KSEPRHSKID KAMECVWKQK LYEPVVIPVG KLFRPNERQV AQLAKKDYLG
200
201
KATVVASVVD QDSFSGFAPL QPQAAEPPPR PKTPEIFRAL EGEAHRVLFG
250
251
FVPETKEELQ VMPGNIVFVL KKGNDNWATV MFNGQKGLVP CNYLEPVELR
300
301
IHPQQQPQEE SSPQSDIPAP PSSKAPGRPQ LSPGQKQKEE PKEVKLSVPM
350
351
PYTLKVHYKY TVVMKTQPGL PYSQVRDMVS KKLELRLEHT KLSYRPRDSN
400
401
ELVPLSEDSM KDAWGQVKNY CLTLWCENTV GDQGFPDEPK ESEKADANNQ
450
451
TTEPQLKKGS QVEALFSYEA TQPEDLEFQE GDIILVLSKV NEEWLEGECK
500
501
GKVGIFPKVF VEDCATTDLE STRREV                          
526
 

Show the unformatted sequence.

Checksums:
CRC64:EC136766E1915376
MD5:b5089a9725bd3c15a66be8e35106be55

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PB1 351 - 427 1OEY B 351 - 427 Show 3D Structure View in InterPro
351 - 428 1OEY A 351 - 428 Show 3D Structure View in InterPro
D 351 - 428 Show 3D Structure View in InterPro
352 - 428 1OEY C 352 - 428 Show 3D Structure View in InterPro
SH3_1 246 - 291 2DMO A 11 - 56 Show 3D Structure View in InterPro
463 - 508 1K4U S 463 - 508 Show 3D Structure View in InterPro
TPR_8 37 - 69 1E96 B 37 - 69 Show 3D Structure View in InterPro
1HH8 A 37 - 69 Show 3D Structure View in InterPro
1WM5 A 37 - 69 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;