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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PEPC_HUMAN (P20142)

Summary

This is the summary of UniProt entry PEPC_HUMAN (P20142).

Description: Gastricsin EC=3.4.23.3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 388 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 16
Pfam A1_Propeptide 18 46
Pfam Asp 72 387
disorder n/a 117 118
low_complexity n/a 218 232

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P20142. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKWMVVVLVC LQLLEAAVVK VPLKKFKSIR ETMKEKGLLG EFLRTHKYDP
50
51
AWKYRFGDLS VTYEPMAYMD AAYFGEISIG TPPQNFLVLF DTGSSNLWVP
100
101
SVYCQSQACT SHSRFNPSES STYSTNGQTF SLQYGSGSLT GFFGYDTLTV
150
151
QSIQVPNQEF GLSENEPGTN FVYAQFDGIM GLAYPALSVD EATTAMQGMV
200
201
QEGALTSPVF SVYLSNQQGS SGGAVVFGGV DSSLYTGQIY WAPVTQELYW
250
251
QIGIEEFLIG GQASGWCSEG CQAIVDTGTS LLTVPQQYMS ALLQATGAQE
300
301
DEYGQFLVNC NSIQNLPSLT FIINGVEFPL PPSSYILSNN GYCTVGVEPT
350
351
YLSSQNGQPL WILGDVFLRS YYSVYDLGNN RVGFATAA             
388
 

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Checksums:
CRC64:F862DFDC1438BB92
MD5:8f71d213bea58ee7a5ddb21a4a5cc320

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
A1_Propeptide 18 - 37 1AVF P 2 - 21 Jmol OpenAstexViewer
18 - 38 1AVF Q 2 - 22 Jmol OpenAstexViewer
18 - 46 1HTR P 2 - 30 Jmol OpenAstexViewer
Asp 72 - 387 1AVF A 13 - 328 Jmol OpenAstexViewer
J 13 - 328 Jmol OpenAstexViewer
1HTR B 13 - 328 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.