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13  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RAB5A_HUMAN (P20339)

Summary

This is the summary of UniProt entry RAB5A_HUMAN (P20339).

Description: Ras-related protein Rab-5A
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 215 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 9
Pfam Ras 22 183
disorder n/a 181 215

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P20339. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE
50
51
STIGAAFLTQ TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY
100
101
DITNEESFAR AKNWVKELQR QASPNIVIAL SGNKADLANK RAVDFQEAQS
150
151
YADDNSLLFM ETSAKTSMNV NEIFMAIAKK LPKNEPQNPG ANSARGRGVD
200
201
LTEPTQPTRN QCCSN                                      
215
 

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Checksums:
CRC64:EC03DDF96BBEF821
MD5:232397a45f0284f0a9f72f1a349cbd2a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ras 22 - 181 1N6H A 22 - 181 Jmol OpenAstexViewer
1N6I A 22 - 181 Jmol OpenAstexViewer
1N6K A 22 - 181 Jmol OpenAstexViewer
1N6N A 22 - 181 Jmol OpenAstexViewer
1N6P A 22 - 181 Jmol OpenAstexViewer
1N6R A 22 - 181 Jmol OpenAstexViewer
22 - 182 1N6L A 22 - 182 Jmol OpenAstexViewer
1TU3 A 22 - 182 Jmol OpenAstexViewer
B 22 - 182 Jmol OpenAstexViewer
D 22 - 182 Jmol OpenAstexViewer
E 22 - 182 Jmol OpenAstexViewer
1TU4 B 22 - 182 Jmol OpenAstexViewer
D 22 - 182 Jmol OpenAstexViewer
4Q9U B 22 - 182 Jmol OpenAstexViewer
F 22 - 182 Jmol OpenAstexViewer
22 - 183 1N6O A 22 - 183 Jmol OpenAstexViewer
1R2Q A 22 - 183 Jmol OpenAstexViewer
1TU3 C 22 - 183 Jmol OpenAstexViewer
1TU4 A 22 - 183 Jmol OpenAstexViewer
C 22 - 183 Jmol OpenAstexViewer
3MJH A 22 - 183 Jmol OpenAstexViewer
C 22 - 183 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.