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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MSH3_HUMAN (P20585)

Summary

This is the summary of UniProt entry MSH3_HUMAN (P20585).

Description: DNA mismatch repair protein Msh3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1137 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 128
sig_p n/a 1 21
low_complexity n/a 5 18
low_complexity n/a 29 41
low_complexity n/a 50 72
low_complexity n/a 96 106
disorder n/a 153 154
disorder n/a 183 186
disorder n/a 211 220
Pfam MutS_I 230 343
Pfam MutS_II 366 523
Pfam MutS_III 540 838
Pfam MutS_V 892 1094
disorder n/a 1122 1123

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P20585. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRRKPASGG LAASSSAPAR QAVLSRFFQS TGSLKSTSSS TGAADQVDPG
50
51
AAAAAAAAAA AAPPAPPAPA FPPQLPPHIA TEIDRRKKRP LENDGPVKKK
100
101
VKKVQQKEGG SDLGMSGNSE PKKCLRTRNV SKSLEKLKEF CCDSALPQSR
150
151
VQTESLQERF AVLPKCTDFD DISLLHAKNA VSSEDSKRQI NQKDTTLFDL
200
201
SQFGSSNTSH ENLQKTASKS ANKRSKSIYT PLELQYIEMK QQHKDAVLCV
250
251
ECGYKYRFFG EDAEIAAREL NIYCHLDHNF MTASIPTHRL FVHVRRLVAK
300
301
GYKVGVVKQT ETAALKAIGD NRSSLFSRKL TALYTKSTLI GEDVNPLIKL
350
351
DDAVNVDEIM TDTSTSYLLC ISENKENVRD KKKGNIFIGI VGVQPATGEV
400
401
VFDSFQDSAS RSELETRMSS LQPVELLLPS ALSEQTEALI HRATSVSVQD
450
451
DRIRVERMDN IYFEYSHAFQ AVTEFYAKDT VDIKGSQIIS GIVNLEKPVI
500
501
CSLAAIIKYL KEFNLEKMLS KPENFKQLSS KMEFMTINGT TLRNLEILQN
550
551
QTDMKTKGSL LWVLDHTKTS FGRRKLKKWV TQPLLKLREI NARLDAVSEV
600
601
LHSESSVFGQ IENHLRKLPD IERGLCSIYH KKCSTQEFFL IVKTLYHLKS
650
651
EFQAIIPAVN SHIQSDLLRT VILEIPELLS PVEHYLKILN EQAAKVGDKT
700
701
ELFKDLSDFP LIKKRKDEIQ GVIDEIRMHL QEIRKILKNP SAQYVTVSGQ
750
751
EFMIEIKNSA VSCIPTDWVK VGSTKAVSRF HSPFIVENYR HLNQLREQLV
800
801
LDCSAEWLDF LEKFSEHYHS LCKAVHHLAT VDCIFSLAKV AKQGDYCRPT
850
851
VQEERKIVIK NGRHPVIDVL LGEQDQYVPN NTDLSEDSER VMIITGPNMG
900
901
GKSSYIKQVA LITIMAQIGS YVPAEEATIG IVDGIFTRMG AADNIYKGQS
950
951
TFMEELTDTA EIIRKATSQS LVILDELGRG TSTHDGIAIA YATLEYFIRD
1000
1001
VKSLTLFVTH YPPVCELEKN YSHQVGNYHM GFLVSEDESK LDPGAAEQVP
1050
1051
DFVTFLYQIT RGIAARSYGL NVAKLADVPG EILKKAAHKS KELEGLINTK
1100
1101
RKRLKYFAKL WTMHNAQDLQ KWTEEFNMEE TQTSLLH              
1137
 

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Checksums:
CRC64:FBAE6B84D3F86032
MD5:7ee910fc512d29b2e9f08f1774a31786

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MutS_I 230 - 343 3THW B 221 - 334 Jmol OpenAstexViewer
3THX B 221 - 334 Jmol OpenAstexViewer
3THY B 221 - 334 Jmol OpenAstexViewer
3THZ B 221 - 334 Jmol OpenAstexViewer
MutS_II 366 - 523 3THW B 357 - 514 Jmol OpenAstexViewer
3THX B 357 - 514 Jmol OpenAstexViewer
3THY B 357 - 514 Jmol OpenAstexViewer
3THZ B 357 - 514 Jmol OpenAstexViewer
MutS_III 540 - 838 3THW B 531 - 829 Jmol OpenAstexViewer
3THX B 531 - 829 Jmol OpenAstexViewer
3THY B 531 - 829 Jmol OpenAstexViewer
3THZ B 531 - 829 Jmol OpenAstexViewer
MutS_V 892 - 1094 3THW B 883 - 1085 Jmol OpenAstexViewer
3THX B 883 - 1085 Jmol OpenAstexViewer
3THY B 883 - 1085 Jmol OpenAstexViewer
3THZ B 883 - 1085 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.