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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BCL3_HUMAN (P20749)

Summary

This is the summary of UniProt entry BCL3_HUMAN (P20749).

Description: B-cell lymphoma 3 protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 454 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 52
low_complexity n/a 18 33
disorder n/a 64 71
low_complexity n/a 78 92
disorder n/a 125 130
disorder n/a 138 139
Pfam Ank 172 203
disorder n/a 207 208
Pfam Ank 241 273
Pfam Ank 275 306
disorder n/a 306 309
disorder n/a 333 337
disorder n/a 339 345
disorder n/a 351 354
disorder n/a 357 423
low_complexity n/a 381 397
low_complexity n/a 388 411
low_complexity n/a 416 434
disorder n/a 425 426
disorder n/a 428 454
low_complexity n/a 434 453

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P20749. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA
50
51
AGLVVPLDPL RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP
100
101
FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA
150
151
VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA
200
201
LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY DGLTALHVAV
250
251
NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA
300
301
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR
350
351
SRRVIDILRG KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS
400
401
SSPSQSPPRD PPGFPMAPPN FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA
450
451
PGGS                                                  
454
 

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Checksums:
CRC64:385F5320DB72C0E0
MD5:803333422af6ad88f144f1191f19a594

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ank 172 - 203 1K1A A 164 - 195 Jmol OpenAstexViewer
1K1B A 164 - 195 Jmol OpenAstexViewer
241 - 273 1K1A A 233 - 265 Jmol OpenAstexViewer
1K1B A 233 - 265 Jmol OpenAstexViewer
275 - 306 1K1A A 267 - 298 Jmol OpenAstexViewer
1K1B A 267 - 298 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.