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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RASA1_HUMAN (P20936)

Summary

This is the summary of UniProt entry RASA1_HUMAN (P20936).

Description: Ras GTPase-activating protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1047 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 18
low_complexity n/a 15 28
low_complexity n/a 38 49
low_complexity n/a 50 67
low_complexity n/a 72 108
disorder n/a 119 120
disorder n/a 127 131
low_complexity n/a 127 150
disorder n/a 133 141
disorder n/a 143 172
Pfam SH2 181 256
disorder n/a 202 204
low_complexity n/a 270 285
Pfam SH3_1 285 333
Pfam SH2 351 426
Pfam PH 475 577
low_complexity n/a 476 492
Pfam C2 594 692
Pfam RasGAP 835 942
disorder n/a 981 986
disorder n/a 988 989
disorder n/a 1014 1015
disorder n/a 1040 1047

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P20936. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP
50
51
GLVETGVAGT LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA
100
101
GVAGAAVAGP SGDMALTKLP TSLLAETLGP GGGFPPLPPP PYLPPLGAGL
150
151
GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ WYHGKLDRTI AEERLRQAGK
200
201
SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY IGGRRFSSLS
250
251
DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS
300
301
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI
350
351
WFHGKISKQE AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK
400
401
ICPTPNNQFM MGGRYYNSIG DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL
450
451
NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY LLKKGKGKRW KNLYFILEGS
500
501
DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC FQIVVQHFSE
550
551
EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI
600
601
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD
650
651
INRFEITLSN KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG
700
701
IEPGSLRVRA RYSMEKIMPE EEYSEFKELI LQKELHVVYA LSHVCGQDRT
750
751
LLASILLRIF LHEKLESLLL CTLNDREISM EDEATTLFRA TTLASTLMEQ
800
801
YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED VNTNLTHLLN
850
851
ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV
900
901
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE
950
951
PYMEGVNPFI KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE
1000
1001
ICVAHSDELR TLSNERGAQQ HVLKKLLAIT ELLQQKQNQY TKTNDVR   
1047
 

Show the unformatted sequence.

Checksums:
CRC64:C35B6567F5BC5370
MD5:42b9c032c3c366df42c21cdd9dbd2cf7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RasGAP 835 - 942 1WER A 835 - 942 Jmol OpenAstexViewer
1WQ1 G 835 - 942 Jmol OpenAstexViewer
SH2 351 - 426 2GSB A 18 - 93 Jmol OpenAstexViewer
SH3_1 285 - 333 2GQI A 11 - 59 Jmol OpenAstexViewer
2J05 A 285 - 333 Jmol OpenAstexViewer
B 285 - 333 Jmol OpenAstexViewer
2J06 A 285 - 333 Jmol OpenAstexViewer
B 285 - 333 Jmol OpenAstexViewer
2M51 A 6 - 54 Jmol OpenAstexViewer
4FSS A 285 - 333 Jmol OpenAstexViewer
B 285 - 333 Jmol OpenAstexViewer
C 285 - 333 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.