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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ACOC_HUMAN (P21399)

Summary

This is the summary of UniProt entry ACOC_HUMAN (P21399).

Description: Cytoplasmic aconitate hydratase EC=4.2.1.3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 889 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Aconitase 59 564
low_complexity n/a 145 155
low_complexity n/a 212 223
low_complexity n/a 270 284
disorder n/a 682 683
Pfam Aconitase_C 692 821

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P21399. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSNPFAHLAE PLDPVQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAIRNC
50
51
DEFLVKKQDI ENILHWNVTQ HKNIEVPFKP ARVILQDFTG VPAVVDFAAM
100
101
RDAVKKLGGD PEKINPVCPA DLVIDHSIQV DFNRRADSLQ KNQDLEFERN
150
151
RERFEFLKWG SQAFHNMRII PPGSGIIHQV NLEYLARVVF DQDGYYYPDS
200
201
LVGTDSHTTM IDGLGILGWG VGGIEAEAVM LGQPISMVLP QVIGYRLMGK
250
251
PHPLVTSTDI VLTITKHLRQ VGVVGKFVEF FGPGVAQLSI ADRATIANMC
300
301
PEYGATAAFF PVDEVSITYL VQTGRDEEKL KYIKKYLQAV GMFRDFNDPS
350
351
QDPDFTQVVE LDLKTVVPCC SGPKRPQDKV AVSDMKKDFE SCLGAKQGFK
400
401
GFQVAPEHHN DHKTFIYDNT EFTLAHGSVV IAAITSCTNT SNPSVMLGAG
450
451
LLAKKAVDAG LNVMPYIKTS LSPGSGVVTY YLQESGVMPY LSQLGFDVVG
500
501
YGCMTCIGNS GPLPEPVVEA ITQGDLVAVG VLSGNRNFEG RVHPNTRANY
550
551
LASPPLVIAY AIAGTIRIDF EKEPLGVNAK GQQVFLKDIW PTRDEIQAVE
600
601
RQYVIPGMFK EVYQKIETVN ESWNALATPS DKLFFWNSKS TYIKSPPFFE
650
651
NLTLDLQPPK SIVDAYVLLN LGDSVTTDHI SPAGNIARNS PAARYLTNRG
700
701
LTPREFNSYG SRRGNDAVMA RGTFANIRLL NRFLNKQAPQ TIHLPSGEIL
750
751
DVFDAAERYQ QAGLPLIVLA GKEYGAGSSR DWAAKGPFLL GIKAVLAESY
800
801
ERIHRSNLVG MGVIPLEYLP GENADALGLT GQERYTIIIP ENLKPQMKVQ
850
851
VKLDTGKTFQ AVMRFDTDVE LTYFLNGGIL NYMIRKMAK            
889
 

Show the unformatted sequence.

Checksums:
CRC64:E1A05AF701D46DCB
MD5:69d3782d37f6224d6885985c323e1c96

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Aconitase 59 - 564 2B3X A 59 - 564 Jmol OpenAstexViewer
2B3Y A 59 - 564 Jmol OpenAstexViewer
B 59 - 564 Jmol OpenAstexViewer
Aconitase_C 692 - 821 2B3X A 692 - 821 Jmol OpenAstexViewer
2B3Y A 692 - 821 Jmol OpenAstexViewer
B 692 - 821 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.