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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MDR3_HUMAN (P21439)

Summary

This is the summary of UniProt entry MDR3_HUMAN (P21439).

Description: Phosphatidylcholine translocator ABCB4 {ECO:0000305} EC=3.6.3.44
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1286 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 27 37
transmembrane n/a 55 78
Pfam ABC_membrane 57 345
transmembrane n/a 117 142
transmembrane n/a 192 211
transmembrane n/a 217 235
low_complexity n/a 243 261
transmembrane n/a 297 318
transmembrane n/a 330 351
Pfam ABC_tran 412 561
disorder n/a 570 574
disorder n/a 639 642
disorder n/a 644 646
disorder n/a 648 650
transmembrane n/a 708 733
Pfam ABC_membrane 711 985
low_complexity n/a 752 770
transmembrane n/a 753 776
low_complexity n/a 765 776
transmembrane n/a 832 852
low_complexity n/a 855 860
transmembrane n/a 858 879
coiled_coil n/a 872 892
transmembrane n/a 934 953
transmembrane n/a 973 994
Pfam ABC_tran 1052 1210
disorder n/a 1175 1178

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P21439. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDLEAAKNGT AWRPTSAEGD FELGISSKQK RKKTKTVKMI GVLTLFRYSD
50
51
WQDKLFMSLG TIMAIAHGSG LPLMMIVFGE MTDKFVDTAG NFSFPVNFSL
100
101
SLLNPGKILE EEMTRYAYYY SGLGAGVLVA AYIQVSFWTL AAGRQIRKIR
150
151
QKFFHAILRQ EIGWFDINDT TELNTRLTDD ISKISEGIGD KVGMFFQAVA
200
201
TFFAGFIVGF IRGWKLTLVI MAISPILGLS AAVWAKILSA FSDKELAAYA
250
251
KAGAVAEEAL GAIRTVIAFG GQNKELERYQ KHLENAKEIG IKKAISANIS
300
301
MGIAFLLIYA SYALAFWYGS TLVISKEYTI GNAMTVFFSI LIGAFSVGQA
350
351
APCIDAFANA RGAAYVIFDI IDNNPKIDSF SERGHKPDSI KGNLEFNDVH
400
401
FSYPSRANVK ILKGLNLKVQ SGQTVALVGS SGCGKSTTVQ LIQRLYDPDE
450
451
GTINIDGQDI RNFNVNYLRE IIGVVSQEPV LFSTTIAENI CYGRGNVTMD
500
501
EIKKAVKEAN AYEFIMKLPQ KFDTLVGERG AQLSGGQKQR IAIARALVRN
550
551
PKILLLDEAT SALDTESEAE VQAALDKARE GRTTIVIAHR LSTVRNADVI
600
601
AGFEDGVIVE QGSHSELMKK EGVYFKLVNM QTSGSQIQSE EFELNDEKAA
650
651
TRMAPNGWKS RLFRHSTQKN LKNSQMCQKS LDVETDGLEA NVPPVSFLKV
700
701
LKLNKTEWPY FVVGTVCAIA NGGLQPAFSV IFSEIIAIFG PGDDAVKQQK
750
751
CNIFSLIFLF LGIISFFTFF LQGFTFGKAG EILTRRLRSM AFKAMLRQDM
800
801
SWFDDHKNST GALSTRLATD AAQVQGATGT RLALIAQNIA NLGTGIIISF
850
851
IYGWQLTLLL LAVVPIIAVS GIVEMKLLAG NAKRDKKELE AAGKIATEAI
900
901
ENIRTVVSLT QERKFESMYV EKLYGPYRNS VQKAHIYGIT FSISQAFMYF
950
951
SYAGCFRFGA YLIVNGHMRF RDVILVFSAI VFGAVALGHA SSFAPDYAKA
1000
1001
KLSAAHLFML FERQPLIDSY SEEGLKPDKF EGNITFNEVV FNYPTRANVP
1050
1051
VLQGLSLEVK KGQTLALVGS SGCGKSTVVQ LLERFYDPLA GTVFVDFGFQ
1100
1101
LLDGQEAKKL NVQWLRAQLG IVSQEPILFD CSIAENIAYG DNSRVVSQDE
1150
1151
IVSAAKAANI HPFIETLPHK YETRVGDKGT QLSGGQKQRI AIARALIRQP
1200
1201
QILLLDEATS ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV
1250
1251
VFQNGRVKEH GTHQQLLAQK GIYFSMVSVQ AGTQNL               
1286
 

Show the unformatted sequence.

Checksums:
CRC64:9A9066F2292F2CCF
MD5:19746c495e0672905bb0d147ea9c9cc9

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.