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40  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FGFR2_HUMAN (P21802)

Summary

This is the summary of UniProt entry FGFR2_HUMAN (P21802).

Description: Fibroblast growth factor receptor 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 821 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 26
disorder n/a 29 32
low_complexity n/a 30 39
disorder n/a 36 41
disorder n/a 43 46
low_complexity n/a 124 141
disorder n/a 130 157
Pfam I-set 162 248
disorder n/a 190 194
Pfam I-set 260 359
Pfam FGFR3_TM 371 401
transmembrane n/a 378 398
disorder n/a 409 410
low_complexity n/a 430 439
disorder n/a 432 433
Pfam Pkinase_Tyr 481 757
disorder n/a 514 516
disorder n/a 774 775
disorder n/a 783 786
low_complexity n/a 784 798
disorder n/a 790 796
disorder n/a 802 803
disorder n/a 809 810
disorder n/a 820 821

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P21802. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVSWGRFICL VVVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEVY
50
51
VAAPGESLEV RCLLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR
100
101
DSGLYACTAS RTVDSETWYF MVNVTDAISS GDDEDDTDGA EDFVSENSNN
150
151
KRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPMPTMR WLKNGKEFKQ
200
201
EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CVVENEYGSI NHTYHLDVVE
250
251
RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK
300
301
YGPDGLPYLK VLKAAGVNTT DKEIEVLYIR NVTFEDAGEY TCLAGNSIGI
350
351
SFHSAWLTVL PAPGREKEIT ASPDYLEIAI YCIGVFLIAC MVVTVILCRM
400
401
KNTTKKPDFS SQPAVHKLTK RIPLRRQVTV SAESSSSMNS NTPLVRITTR
450
451
LSSTADTPML AGVSEYELPE DPKWEFPRDK LTLGKPLGEG CFGQVVMAEA
500
501
VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM IGKHKNIINL
550
551
LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF
600
601
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD
650
651
INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG
700
701
GSPYPGIPVE ELFKLLKEGH RMDKPANCTN ELYMMMRDCW HAVPSQRPTF
750
751
KQLVEDLDRI LTLTTNEEYL DLSQPLEQYS PSYPDTRSSC SSGDDSVFSP
800
801
DPMPYEPCLP QYPHINGSVK T                               
821
 

Show the unformatted sequence.

Checksums:
CRC64:6CD5001C960ED82F
MD5:8278583234a3eda2a192d8bb50e1fab8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
I-set 162 - 248 1DJS A 162 - 248 Jmol OpenAstexViewer
1E0O B 162 - 248 Jmol OpenAstexViewer
D 162 - 248 Jmol OpenAstexViewer
1EV2 E 162 - 248 Jmol OpenAstexViewer
F 162 - 248 Jmol OpenAstexViewer
G 162 - 248 Jmol OpenAstexViewer
H 162 - 248 Jmol OpenAstexViewer
1II4 E 162 - 248 Jmol OpenAstexViewer
F 162 - 248 Jmol OpenAstexViewer
G 162 - 248 Jmol OpenAstexViewer
H 162 - 248 Jmol OpenAstexViewer
1IIL E 162 - 248 Jmol OpenAstexViewer
F 162 - 248 Jmol OpenAstexViewer
G 162 - 248 Jmol OpenAstexViewer
H 162 - 248 Jmol OpenAstexViewer
1NUN B 162 - 248 Jmol OpenAstexViewer
1WVZ A 17 - 103 Jmol OpenAstexViewer
2FDB P 2162 - 2248 Jmol OpenAstexViewer
R 3162 - 3248 Jmol OpenAstexViewer
3CAF A 162 - 248 Jmol OpenAstexViewer
3CU1 A 162 - 248 Jmol OpenAstexViewer
C 162 - 248 Jmol OpenAstexViewer
3DAR A 162 - 248 Jmol OpenAstexViewer
B 162 - 248 Jmol OpenAstexViewer
3EUU A 162 - 248 Jmol OpenAstexViewer
B 162 - 248 Jmol OpenAstexViewer
3OJ2 C 162 - 248 Jmol OpenAstexViewer
D 162 - 248 Jmol OpenAstexViewer
3OJM B 162 - 248 Jmol OpenAstexViewer
4J23 A 162 - 248 Jmol OpenAstexViewer
4WV1 C 159 - 245 Jmol OpenAstexViewer
F 159 - 245 Jmol OpenAstexViewer
260 - 359 1DJS A 260 - 359 Jmol OpenAstexViewer
1E0O B 260 - 359 Jmol OpenAstexViewer
D 260 - 359 Jmol OpenAstexViewer
1EV2 E 260 - 359 Jmol OpenAstexViewer
F 260 - 359 Jmol OpenAstexViewer
G 260 - 359 Jmol OpenAstexViewer
H 260 - 359 Jmol OpenAstexViewer
1II4 E 260 - 359 Jmol OpenAstexViewer
F 260 - 359 Jmol OpenAstexViewer
G 260 - 359 Jmol OpenAstexViewer
H 260 - 359 Jmol OpenAstexViewer
1IIL E 260 - 359 Jmol OpenAstexViewer
F 260 - 359 Jmol OpenAstexViewer
G 260 - 359 Jmol OpenAstexViewer
H 260 - 359 Jmol OpenAstexViewer
1NUN B 260 - 357 Jmol OpenAstexViewer
2FDB P 2260 - 2359 Jmol OpenAstexViewer
R 3260 - 3359 Jmol OpenAstexViewer
3OJ2 C 260 - 357 Jmol OpenAstexViewer
D 260 - 357 Jmol OpenAstexViewer
3OJM B 260 - 357 Jmol OpenAstexViewer
4J23 A 260 - 359 Jmol OpenAstexViewer
Pkinase_Tyr 481 - 757 1GJO A 481 - 757 Jmol OpenAstexViewer
1OEC A 481 - 757 Jmol OpenAstexViewer
2PSQ A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
2PVF A 481 - 757 Jmol OpenAstexViewer
2PVY A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
C 481 - 757 Jmol OpenAstexViewer
D 481 - 757 Jmol OpenAstexViewer
2PWL A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
2PY3 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
2PZ5 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
2PZP A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
2PZR A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
2Q0B A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
3B2T A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
3CLY A 1481 - 1757 Jmol OpenAstexViewer
3RI1 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
4J95 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
C 481 - 757 Jmol OpenAstexViewer
D 481 - 757 Jmol OpenAstexViewer
4J96 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
4J97 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
C 481 - 757 Jmol OpenAstexViewer
D 481 - 757 Jmol OpenAstexViewer
4J98 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
4J99 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
C 481 - 757 Jmol OpenAstexViewer
D 481 - 757 Jmol OpenAstexViewer
5EG3 A 481 - 757 Jmol OpenAstexViewer
5UGL A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
5UGX A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
5UHN A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer
5UI0 A 481 - 757 Jmol OpenAstexViewer
B 481 - 757 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.