Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
46  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FGFR2_HUMAN (P21802)

Summary

This is the summary of UniProt entry FGFR2_HUMAN (P21802).

Description: Fibroblast growth factor receptor 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 821 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 26
disorder n/a 29 32
low_complexity n/a 31 40
disorder n/a 36 41
Pfam Ig_3 39 110
disorder n/a 43 46
low_complexity n/a 125 142
disorder n/a 130 157
Pfam I-set 162 248
disorder n/a 190 194
Pfam I-set 260 359
transmembrane n/a 378 398
disorder n/a 409 410
low_complexity n/a 431 440
disorder n/a 432 433
Pfam PK_Tyr_Ser-Thr 481 757
disorder n/a 514 516
disorder n/a 774 775
disorder n/a 783 786
low_complexity n/a 785 799
disorder n/a 790 796
disorder n/a 802 803
disorder n/a 809 810
disorder n/a 820 821

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P21802. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVSWGRFICL VVVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEVY
50
51
VAAPGESLEV RCLLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR
100
101
DSGLYACTAS RTVDSETWYF MVNVTDAISS GDDEDDTDGA EDFVSENSNN
150
151
KRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPMPTMR WLKNGKEFKQ
200
201
EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CVVENEYGSI NHTYHLDVVE
250
251
RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK
300
301
YGPDGLPYLK VLKAAGVNTT DKEIEVLYIR NVTFEDAGEY TCLAGNSIGI
350
351
SFHSAWLTVL PAPGREKEIT ASPDYLEIAI YCIGVFLIAC MVVTVILCRM
400
401
KNTTKKPDFS SQPAVHKLTK RIPLRRQVTV SAESSSSMNS NTPLVRITTR
450
451
LSSTADTPML AGVSEYELPE DPKWEFPRDK LTLGKPLGEG CFGQVVMAEA
500
501
VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM IGKHKNIINL
550
551
LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF
600
601
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD
650
651
INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG
700
701
GSPYPGIPVE ELFKLLKEGH RMDKPANCTN ELYMMMRDCW HAVPSQRPTF
750
751
KQLVEDLDRI LTLTTNEEYL DLSQPLEQYS PSYPDTRSSC SSGDDSVFSP
800
801
DPMPYEPCLP QYPHINGSVK T                               
821
 

Show the unformatted sequence.

Checksums:
CRC64:6CD5001C960ED82F
MD5:8278583234a3eda2a192d8bb50e1fab8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
I-set 162 - 248 1DJS A 162 - 248 Show 3D Structure View in InterPro
1E0O B 162 - 248 Show 3D Structure View in InterPro
D 162 - 248 Show 3D Structure View in InterPro
1EV2 E 162 - 248 Show 3D Structure View in InterPro
F 162 - 248 Show 3D Structure View in InterPro
G 162 - 248 Show 3D Structure View in InterPro
H 162 - 248 Show 3D Structure View in InterPro
1II4 E 162 - 248 Show 3D Structure View in InterPro
F 162 - 248 Show 3D Structure View in InterPro
G 162 - 248 Show 3D Structure View in InterPro
H 162 - 248 Show 3D Structure View in InterPro
1IIL E 162 - 248 Show 3D Structure View in InterPro
F 162 - 248 Show 3D Structure View in InterPro
G 162 - 248 Show 3D Structure View in InterPro
H 162 - 248 Show 3D Structure View in InterPro
1NUN B 162 - 248 Show 3D Structure View in InterPro
1WVZ A 17 - 103 Show 3D Structure View in InterPro
2FDB P 2162 - 2248 Show 3D Structure View in InterPro
R 3162 - 3248 Show 3D Structure View in InterPro
3CAF A 162 - 248 Show 3D Structure View in InterPro
3CU1 A 162 - 248 Show 3D Structure View in InterPro
C 162 - 248 Show 3D Structure View in InterPro
3DAR A 162 - 248 Show 3D Structure View in InterPro
B 162 - 248 Show 3D Structure View in InterPro
3EUU A 162 - 248 Show 3D Structure View in InterPro
B 162 - 248 Show 3D Structure View in InterPro
3OJ2 C 162 - 248 Show 3D Structure View in InterPro
D 162 - 248 Show 3D Structure View in InterPro
3OJM B 162 - 248 Show 3D Structure View in InterPro
4J23 A 162 - 248 Show 3D Structure View in InterPro
4WV1 C 159 - 245 Show 3D Structure View in InterPro
F 159 - 245 Show 3D Structure View in InterPro
260 - 359 1DJS A 260 - 359 Show 3D Structure View in InterPro
1E0O B 260 - 359 Show 3D Structure View in InterPro
D 260 - 359 Show 3D Structure View in InterPro
1EV2 E 260 - 359 Show 3D Structure View in InterPro
F 260 - 359 Show 3D Structure View in InterPro
G 260 - 359 Show 3D Structure View in InterPro
H 260 - 359 Show 3D Structure View in InterPro
1II4 E 260 - 359 Show 3D Structure View in InterPro
F 260 - 359 Show 3D Structure View in InterPro
G 260 - 359 Show 3D Structure View in InterPro
H 260 - 359 Show 3D Structure View in InterPro
1IIL E 260 - 359 Show 3D Structure View in InterPro
F 260 - 359 Show 3D Structure View in InterPro
G 260 - 359 Show 3D Structure View in InterPro
H 260 - 359 Show 3D Structure View in InterPro
1NUN B 260 - 357 Show 3D Structure View in InterPro
2FDB P 2260 - 2359 Show 3D Structure View in InterPro
R 3260 - 3359 Show 3D Structure View in InterPro
3OJ2 C 260 - 357 Show 3D Structure View in InterPro
D 260 - 357 Show 3D Structure View in InterPro
3OJM B 260 - 357 Show 3D Structure View in InterPro
4J23 A 260 - 359 Show 3D Structure View in InterPro
PK_Tyr_Ser-Thr 481 - 757 1GJO A 481 - 757 Show 3D Structure View in InterPro
1OEC A 481 - 757 Show 3D Structure View in InterPro
2PSQ A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
2PVF A 481 - 757 Show 3D Structure View in InterPro
2PVY A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
C 481 - 757 Show 3D Structure View in InterPro
D 481 - 757 Show 3D Structure View in InterPro
2PWL A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
2PY3 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
2PZ5 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
2PZP A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
2PZR A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
2Q0B A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
3B2T A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
3CLY A 1481 - 1757 Show 3D Structure View in InterPro
3RI1 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
4J95 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
C 481 - 757 Show 3D Structure View in InterPro
D 481 - 757 Show 3D Structure View in InterPro
4J96 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
4J97 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
C 481 - 757 Show 3D Structure View in InterPro
D 481 - 757 Show 3D Structure View in InterPro
4J98 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
4J99 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
C 481 - 757 Show 3D Structure View in InterPro
D 481 - 757 Show 3D Structure View in InterPro
5EG3 A 481 - 757 Show 3D Structure View in InterPro
5UGL A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
5UGX A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
5UHN A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
5UI0 A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
6AGX A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
C 481 - 757 Show 3D Structure View in InterPro
D 481 - 757 Show 3D Structure View in InterPro
6LVK A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
6LVL A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
6V6Q A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
C 481 - 757 Show 3D Structure View in InterPro
D 481 - 757 Show 3D Structure View in InterPro
7KIA A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
7KIE A 481 - 757 Show 3D Structure View in InterPro
B 481 - 757 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;